It’s interesting that the results appear to have been the same irrespective of the chemical being used. Sounds like the BP drug doesn’t work as well / is counteracted by daily activities.
My wife and I had a little white coat syndrome re higher BP when taken at the beginning of an appointment with a doctor and lower at the end of the appointment.
When I take my bp med the night before, the bps are in the normal range pre and post visit.
“BP drug doesn’t work as well / is counteracted by daily activities.”
Could be a lot of variables impacting blood levels and tissue absorption.
We really don’t how and why our bodies and blood chemistry vary over a 24 hour period.
Some studies are being done with drugs that have something added like a nuclear tag to measure levels over the dosing periods.
Aspirin as a therapeutic for BP was discounted for most studies, except for one that looked at it taken at bed time that seemed to have a positive effect.