Posted on 07/06/2019 2:39:46 PM PDT by ConservativeMind
In a study using brain tissue from deceased human donors, Johns Hopkins Medicine researchers say they found new evidence that schizophrenia can be marked by the buildup of abnormal proteins similar to those found in the brains of people with such neurodegenerative disorders as Alzheimer's or Huntington's diseases.
Rather than rely on categorizing by symptoms, researchers have long sought to better classify types of schizophrenia -- such as those in which abnormal proteins appear to accumulate -- as a potential way to improve and tailor therapies as precision medicine. The researchers aren't sure how common this variation of the disorder is, although they did find it in about half of the brain samples analyzed.
Nucifora says this main finding of the abnormal proteins involved in these processes is consistent with theories of schizophrenia that trace its origins to brain development and to problems with neural communication.
"Researchers have been so focused on the genetics of schizophrenia that they've not paid as much attention to what is going on at the protein level and especially the possibility of protein aggregation," says Nucifora. "This may be a whole new way to look at the disorder and develop more effective therapies."
(Excerpt) Read more at sciencedaily.com ...
Main cause of schizophrenia is illegal drug use.
Marijuana use is a major cause of schizophrenia.
It’s much higher than that.
Yes, my cousin has had schizophrenia for many years from abusing drugs. Once you damage your mind, it’s pretty much irreparable.
What is your source?
Then there is LSD.
My sister left at 18, and briefly used drugs, both marijuana and LSD, to the best of our knowledge. One or the other, or both, did the foul trick.
When she became violently insane, her erstwhile hippie friends called my parents and said, Either come and get her or we call the cops.
She has lived with family ever since, unable to take care of herself. A few months with drugs, 50+ years with paranoid schizophrenia.
She was a Straight-A student with zero behavioural problems before that. I, the youngest, got to grow up with someone who seemed like a living landmine ready to explode in my face at any moment without warning.
My brother merely became violently paranoid and sociopathic - not precisely schizophrenic - from marijuana and cocaine. He is semi-functional, and lives in the desert as a nomad. I stopped seeing him after he beat me and dislocated my jaw. (I kept my bloody injuries secret, lest my father with his weak heart drop dead upon finding out.)
He was never a great student academically, but he was King of the Prom (underclassmen), and got the Who’s Who Award for his Blue-Ribbon artwork, at Palo Alto High. Stanford students knew of him when he was just a sophomore.
I grew up in the Bay Area surrounded by hopheads. Anyone who says Mary Jane is a nice girl is no one I will take seriously.
I never sampled any drugs - ever. That makes me an objective observer. I do not need to contract syphilis (as Nietzsche ostensibly did) to observe the negative deleterious effects of contracting it.
I consider proponents of unnatural drug use libertines, not libertarians (i.e., classic liberals). Unless one lives entirely isolated as my brother now does, drug use will one way or another negatively impact those around one: slacking off at work, causing car accidents on the road.
I have had to do the work of two or three people - while my supposed co-workers were blissed out - often enough that I have no respect for those who choose that lifestyle.
Anecdotal stories don’t mean much. I took acid hundreds of times in high school my sister never did any drugs nor drinks much. She’s a psychological mess and always has been.
Democrat Party membership rosters.
LOL And to think I almost took you seriously.
Yes, as mentioned in number 24, my cousin burned his brain out on some sort of drugs his first year of college and has been bipolar and paranoid-schizophrenic ever since. His parents were wealthy and left him a multi-million dollar trust fund to take care of him, but he has spent long periods where he has disappeared and been living on the streets.
Yes.
The body is your personal tool. But like any tool, it can be neglected and damaged by yourself and others, and that can cause the person to work at a deficit or abnormality. And eventually maybe stop working altogether.
Being left handed apparently doesn’t help.
Like you, I never sampled any drugs - ever. That makes me also an objective observer.
The taint of 1970’s marijuana use can be tied to the increase in crime, paranoia, psychotic episodes, murders and homelessness. And, just maybe, the eventual crash of this country
Marijuana use is a major cause of schizophrenia.
_________
no, genetics is the prime mover.
A number of issues initiate schizophrenia,
Stress seems to be number one...
Sounds like the gene runs it the family and the hallucinogens LSD and Marijuana triggered the first break.
Time Trends in Schizophrenia: Changes in Obstetric Risk Factors with Industrialization
By Richard Warner
Schizophrenia Bulletin, Vol. 21, No. 3, 1995
National Institute of Mental Health
Abstract
The frequency of schizophrenia may have increased during the early stages of industrialization and may now be declining. Early in the process of development, the illness appeared to be more common among the upper classes and later, more common in the lower classes. As with certain other diseases, the occurrence of schizophrenia may be influenced by the transition from poverty to affluence.
There is a meta analysis of 18 different journal articles that all disagree with the author’s opinion about the rate of schizophrenia over the years.
The author’s statement is his opinion. It is not fact.
Further, I have studied this subject from the period when Jung’s boss at the Burgholzli Hospital in Zurich first coined the term schizophrenia in 1911.
Bleuler had coined the term schizophrenia to replace “dementia-praecox.”
My point is that differing diagnosis resulted in much confusion over the years.
For example Bleuler had coined the term schizophrenia in 1911 to replace the diagnosis “dementia-praecox” which translates as early dementia. That’s what schizophrenia was originally considered.
There are 5 sub types of schizophrenia that overlap with many other diagnoses.
I discovered the unique developmental consciousness pattern common in schizophrenics several years ago while working extensively with patients. While I know how to cure it, the process is extremely time consuming and the commitment of my time is too great. It involves collapsing the developmental process and then validating the individual to develop a secure sense of self. A secure sense of self cannot hear the voices that disrupt the patient’s life.
IOWs, according to your statements, recorded rates of schizophrenia have changed because the diagnostic criterion has changed over time. Which makes the author’s statement a matter of differing means of analysis of the history of its diagnostics not an opinion. It also means that recorded rates are unreliable for making any comparisons over time, pro or con.
The main support for the theory that too much dopamine causes schizophrenia is the fact that antipsychotic medications, which are used to treat schizophrenia, block dopamine receptors. The medications are designed to bind to dopamine receptors in the brain, and their effects have helped many people cope with symptoms.
When dopamine levels get even higher, the schizophrenia patient becomes paranoid.
Your evaluation of my statement is correct.
An acquaintance of mine and friend of my wife was the chair of the committee that formulated the DSM or Diagnostic and Statistical Manual of Mental Disorders. He got the royalties on the book sales.
I’ve heard him lecture many times at Hospital Psychiatry Grand Rounds on the changes in diagnosis over the years. It is always shifting by being combined and some diagnoses being eliminated due to current political trends.
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