How might baking soda boost cancer therapy?

ScienceDaily ^ | June 1, 2018 | Source: Ludwig Institute for Cancer Research

[ConservativeMind]

A Ludwig Cancer Research study has uncovered an entirely novel mechanism by which cells enter a state of dormancy as tissues starved of oxygen become increasingly acidic. The study, led by Chi Van Dang, scientific director of the Ludwig Institute for Cancer Research, has potentially significant implications for cancer therapy: Large swaths of solid tumors are often deprived of oxygen, and cells in such patches are thought to be a major source of drug resistance and disease relapses.

Baking soda had previously been reported to enhance cancer immunotherapy by one of the co-authors of the new study, though the mechanism underlying the effect was unclear.

Dang's team, including co-corresponding author Zandra Walton, an MD-PhD student at the University of Pennsylvania Perelman School of Medicine, discovered that mechanism through an intricate series of experiments done at the University of Pennsylvania and Dang's Ludwig lab at the Wistar Institute. It centers on the behavior of lysosomes -- a sack-like cellular organelle that digests proteins and that mTOR moves to when it is ready for action.

"Cells don't want to make proteins or other biomolecules when they're under stress," says Dang. "They want to slow things down and only awaken when things return to normal."

The researchers show that baking soda can reverse this effect. When given to mice in their drinking water, it surprisingly sufficed to neutralize the acidity of hypoxic patches in tumors. This sent lysosomes zipping back to the nuclear periphery in cells -- where RHEB was waiting -- and restored the activity of mTOR.

All this is relevant to cancer because researchers have long known that quiescent cells cannot typically be killed by chemotherapy. Notably, Dang and his team also found that T cell activation, which is essential to most immunotherapies, is similarly compromised under acidic conditions.

[A_perfect_lady]

My friend is on Avastin. She’s in month 14 of glioblastoma. They said her diagnosis was 18 months and it’s looking like that’s going to be exactly right. The tumor growth has slowed, but the progress of her deterioration hasn’t stopped. She seems to age a year every week. These drugs take as much as they give. You live a little longer, calendar wise, but you sleep through most of it, and in the end, it’s like your time on Earth has not been added to, but merely stretched thinner.

[TheNext]

Arm & Hammer baking soda toothpaste.

It still has that flouride junk though.

[logi_cal869]

Obviously I hit a nerve. I really don’t care [sic] what that nerve is, but your argument demonstrates more confusion than that which you proffer on my part.

Your focus on causation to reinforce your superiority complex is telling, but I am not going to school you, so this is for others:

Baking soda is a form of self-medication to mask one or more symptoms and should not be taken without understanding the effects thereof. The internet is rife with harmful hyperbole, and my effort to call this out is in the interest of all.

For you, go ahead, take your PPIs and eat your baking soda. The irony is that it will assuredly give you something else to argue about with the doctor as you wonder what happened to your health. This is because repeated use of either will have the same unintended consequences, each with their own unique complications, both principally as a result of inhibiting the autonomic nervous system’s normal signaling, the ironic result a self-reinforcing delusion as you argue causation with your doctor.

[zeestephen]

Baking Soda...

I recall reading several papers about people inhaling a baking soda and water mist for respiratory cancers.

However, until a few weeks ago, I had never read about drinking it.

One point - most chemo therapies are anti-metabolites, if I understand that correctly. So, if a significant percentage of the cells in a cancerous tumor are dormant at any particular time, I can see that would have an impact on chemotherapy.

[trebb]

Several posts about this but I have missed it if any of them contain dosages...

[MayflowerMadam]

A couple months ago I stopped buying toothpaste with fluoride. It seemed that some health issues became more prevalent after we were bombarded with fluoride. It is in no way scientific, but just an idea.

I remember in the ‘60s everyone in school was taken out of class and given a “fluoride treatment”. Once back to the classroom there was a lot of puking going on.

[ConservativeMind]

Cell is a pay journal, but there is a safe “maximum:”

https://www.livestrong.com/article/376495-the-effects-of-drinking-baking-soda-water/

[LSAggie]

Arm and Hammer baking soda still has the glaring red seal. Over a century of supporting the Left.

You are incorrect. The Arm and Hammer brand was in use 31 years before Armand Hammer was born.

I only looked because we use Arm and Hammer toothpaste and would hate to give it up. It's made in America, not Mexico.

[Faith65]

BKMK FOR LATER

[IronJack]

Actually, blood is slightly into the alkaline pH. If it reaches true neutral pH (7.0), you’re well into acidosis.

Hypoxia results in a buildup of CO2, which, when dissolved in water, makes a weak acid. Sodium bicarbonate is a well-known pH buffering agent.

[Hot Tabasco]

Baking soda is communist. Arm and Hammer baking soda still has the glaring red seal.

That's why I pour it out of its packaging box and into a sealed plastic bowl......

[Georgia Girl 2]

We drink baking soda in water everyday. Keeping your system alkiline does inhibit cancer. So does turmeric which we also use daily for arthritis.

[daniel1212]

Baking soda is communist. Arm and Hammer baking soda still has the glaring red seal. Over a century of supporting the Left.

There is some interesting history on this:

ARM & HAMMER BAKING SODA The muscular arm and raised hammer represent Vulcan, Roman mythological god of fire and metalworking, and was once the symbol of the Vulcan Spice Mill in Brooklyn, N.Y. James A. Church, owner of the firm, took the symbol with him when he shut down the mill in 1867 and went into business with his father, a baking soda manufacturer. Shortly afterwards, the “power” behind Vulcan’s arm and hammer became the trademark of Church’s baking soda, which had the “force” to make bread dough rise.

We can only hypothesize why Church, Patterson, or anyone else decided to use the arm & hammer emblem as a commercial logo at this time. First, it was an established icon that would be easily remembered. As a symbol of the national labor movement, the arm & hammer still retained the positive connotations of integrity and strength derived from the Vulcan myth. This is also the exact time that the seeds of the union label movement were being planted across the country in San Francisco, starting with the Carpenter’s 8 Hour lumber stamp (1869) and the Cigar Maker’s “white men” label (1874). These labels were meant give consumers an economic way to support labor, and to a way to differentiate higher quality union made goods from those produced in sweatshops and other unsanitary conditions. It may be possible that consumers were prepared for the concept of the union label because they had already started to see and trust products that used “honest labor,” the arm & hammer emblem or other variations on this theme as a selling point. - http://www.likelihoodofconfusion.com/nailing-the-arm-and-hammer-trademark/

Church & Dwight Co, Inc. is a major American manufacturer of household products that is based in Ewing, New Jersey. While it manufactures many items, it is best known for its Arm & Hammer line which includes baking soda and a variety of products made with it. Church & Dwight was ranked #652 in the Fortune 500 listing of companies in 2017.[3]

The Arm & Hammer logo, which dates back to the 1860s,[5] is often incorrectly claimed to have originated with tycoon Armand Hammer. Hammer was so often asked about the Church & Dwight brand, however, that he attempted to buy the company. While unsuccessful, Hammer's Occidental Petroleum in 1986 acquired enough stock for him to join the Church & Dwight board of directors.[6] - https://en.wikipedia.org/wiki/Church_%26_Dwight

Armand Hammer...In his 1983 book, Red Carpet, author Joseph Finder discusses Hammer's "extensive involvement with Russia."[25] In Dossier: The Secret History of Armand Hammer, Edward Jay Epstein called Hammer "a virtual spy" for the Soviet Union.[26]

Hammer was a supporter of the Republican Party. He boosted Richard Nixon's presidential campaign with $54,000 in campaign contributions. He pleaded guilty to charges that one of these donations had been made illegally and received probation and a $3,000 fine,[29] but was later pardoned by Republican U.S. President George H. W. Bush

Hammer was very fond of Albert Gore, Jr., and in 1984 under Hammer's guidance Gore, Jr. sought Tennessee's Senate office previously held by Howard Baker. Hammer supposedly promised Gore, Sr. that he could make his son the president of the United States. It was under Hammer's encouragement and support that Gore Jr. sought the Democratic Party presidential nomination in 1988.[45][46]

In the 1980s Hammer owned a considerable amount of stock in Church & Dwight, the company that manufactures Arm & Hammer products; he also served on its board of directors. However, the Arm & Hammer company's brand name did not originate with Armand Hammer. It was in use some 31 years before Hammer was born.[47] He was spurred to buy shares in the company as a result of often being asked about the brand being so close to his name. - https://en.wikipedia.org/wiki/Armand_Hammer

[logi_cal869]

There is a massive amount of hyperbole on the pH of the body, e.g. the “alkaline diet”. Sadly people equate the stomach with alkalinity.

As I mentioned in prior comment, the correlation between canine bladder infections weighs directly upon human health with a cliche’: We are what we eat.

IMHO, Americans are slow-poisoning themselves. This includes Omega-6 toxicity. The synergy of these effects result in not only systemic inflammation but a persistent impaired health state, frequently-exhibiting what most people perceive as minor symptoms but which ‘science’ has failed to connect to the long list of Adult Symptoms & Conditions, including major diseases such as cancer.

There are thousands and thousands of examples of people having cured themselves by reforming their lifestyle.

Unfortunately I cannot share more about what I know or my books’ new approach (it’s revolutionary), but know that one of several mantras I parrot is that self-medication to mask symptoms facilitates impaired health when the cause is not addressed.

That’s why I reacted so strongly to this snake-oil approach, baking soda. It takes time to adjust a person’s body pH, and it certainly does NOT begin with increasing the stomach’s pH...an asinine position which should NEVER have been addressed by an institution as a viable alternative. But then again, it IS “science” which brought us ‘climate change’, right?

[conservativesister]

You mentioned your books, can you tell me what books you have written, and your “author” name. Thanks

[Pelham]

People with kidney failure aren’t clearing waste from their blood and they get acidosis. Sodium bicarb can help with that.

[Pelham]

The gist of the article is that some cancer cells are dormant. And these ‘quiescent’ cancer cells cannot be killed off with chemotherapy- they aren’t taking in the poison. You only kill off the active ones.

Baking soda “wakes up” the quiescent cancer cells so that they are vulnerable to the chemo treatment.

So baking soda alone has no value in treating cancer, it works in conjunction with chemotherapy.

[Yaelle]

Interesting. I pretty much hate chemo. I think one day it will be seen as very very primitive. Sadly, after several people I knew have been dragged through it for breast cancer, now they are saying it’s overkill in many cases. And I just hired someone who had to leave the day before her first day because her husband is not making it through his second round of chemo. So sad. How would he be withoutnthe chemo, I don’t know. Hoping for better paradigms against cancer. This “fight” thing isn’t the best.