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The most complete Ebola genome yet: What it can tell us
L.A. Times ^ | August 28, 2014, 3:04 PM | Deborah Netburn

Posted on 08/28/2014 3:27:01 PM PDT by BenLurkin

An international team of team of scientists has sequenced the RNA of 99 Ebola virus samples collected during the early weeks of the outbreak in Sierra Leone. The feat, described Thursday in the journal Science, gives researchers a powerful new tool in their effort to contain the deadly virus.

...

Scientists are already scouring that sequence for clues to help them design effective drugs and vaccines. It could take years to find them all, said Sabeti, who studies infectious diseases at Harvard and at the Broad Institute in Cambridge, Mass.

For now, evidence embedded in the RNA reveals that the Ebola virus responsible for killing at least 1,552 people so far originated with a single transmission from an animal to a human in Guinea. It also shows that this lineage, which first emerged in humans in 2013, diverged from other variants of Ebola in 2004.

Sabeti and her team began sequencing Ebola samples in June, just days after the virus was first detected in Sierra Leone on May 25. The results have been available to scientists on the National Center for Biotechnology Information’s website since mid-June, almost as soon as the sequencing machines spit them out. “We want to enable everyone in the scientific community to look at the genetic sequences at once and crowd-source a solution,” she said.

The urgency for better treatments is real for Sabeti and her colleagues. Five of the study co-authors in Sierra Leone have died of Ebola since contributing to the research.

(Excerpt) Read more at latimes.com ...


TOPICS: Health/Medicine; Science
KEYWORDS: ebola; virus

1 posted on 08/28/2014 3:27:01 PM PDT by BenLurkin
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To: BenLurkin
Five of the study co-authors in Sierra Leone have died of Ebola since contributing to the research.

Just damn. BTT

2 posted on 08/28/2014 3:28:40 PM PDT by Billthedrill
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To: BenLurkin

This new strain of Ebola is apparently a rapidly evolving one. They managed to witness that mutating in real time.


3 posted on 08/28/2014 3:30:59 PM PDT by Covenantor ("Men are ruled...by liars who refuse them news, and by fools who cannot govern." Chesterton)
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To: BenLurkin

Wall off the infected area now. Anyone foolish enough to go in stays in quarantine before leaving.


4 posted on 08/28/2014 3:33:14 PM PDT by soycd
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To: Covenantor

From wiki:
Like all filoviruses, ebolavirions are filamentous particles that may appear in the shape of a shepherd’s crook or in the shape of a “U” or a “6”, and they may be coiled, toroid, or branched.[38] In general, ebolavirions are 80 nm in width, but vary somewhat in length. In general, the median particle length of ebolaviruses ranges from 974 to 1,086 nm (in contrast to marburgvirions, whose median particle length was measured at 795–828 nm), but particles as long as 14,000 nm have been detected in tissue culture.

Is it not likely to become “airborn” due to it’s size?

Where is Mother Abigail when you need her?


5 posted on 08/28/2014 3:47:27 PM PDT by Gadsden1st
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To: BenLurkin

There are a lot of brave people involved in this.


6 posted on 08/28/2014 3:59:39 PM PDT by ansel12 (LEGAL immigrants, 30 million 1980-2012, continues to remake the nation's electorate for democrats)
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To: Gadsden1st
that may appear in the shape of a shepherd’s crook or in the shape of a “U” or a “6”, and they may be coiled, toroid, or branched.[

When they find one in the shape of three 6's, .... never mind, they won't tell us.


7 posted on 08/28/2014 4:03:10 PM PDT by UCANSEE2 (Lost my tagline on Flight MH370. Sorry for the inconvenience.)
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To: BenLurkin
five of the study co-authors have died

Who better would know how to avoid infection than those studying the virus' spread? That should tell you that they really don't understand how it is spread.

8 posted on 08/28/2014 5:06:02 PM PDT by The Sons of Liberty (I want a Speaker who'll stick that pen and phone where no one but Reggie Love can find it!)
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To: BenLurkin

It could be much more interesting than we’d like, if it began traveling like the flu and unlocked victim’s immune systems for some kind of MRSA-like staph infection.


9 posted on 08/28/2014 5:38:33 PM PDT by familyop (We Baby Boomers are croaking in an avalanche of corruption smelled around the planet.)
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To: The Sons of Liberty
That's the thing that not enough people are talking about.

The top researchers are suiting up, taking all the right precautions and they're still dying like flies. Things are not going as the experts expect. The disease spreads despite all of their efforts to stay safe.

But they tell us we have nothing to worry about. I'm wearing shorts and a t-shirt, so I guess I have nothing to fear. [/s]

10 posted on 08/28/2014 5:39:04 PM PDT by ClearCase_guy ("Harvey Dent, can we trust him?" http://www.youtube.com/watch?v=HBsdV--kLoQ)
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To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...
Ping...

A link to this thread has been posted on the Ebola Surveillance Thread

11 posted on 09/01/2014 11:25:33 AM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing.)
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To: Smokin' Joe

Thanks for the ping!


12 posted on 09/01/2014 7:08:52 PM PDT by Alamo-Girl
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To: Alamo-Girl

You’re Welcome, Alamo-Girl!


13 posted on 09/01/2014 7:51:55 PM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing.)
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Comment #14 Removed by Moderator

To: BenLurkin; neverdem; ProtectOurFreedom; Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; ..
Eeeee-bolllll-aaaaaa ping!

Bring Out Your Dead

Post to me or FReep mail to be on/off the Bring Out Your Dead ping list.

The purpose of the “Bring Out Your Dead” ping list (formerly the “Ebola” ping list) is very early warning of emerging pandemics, as such it has a high false positive rate.

So far the false positive rate is 100%.

At some point we may well have a high mortality pandemic, and likely as not the “Bring Out Your Dead” threads will miss the beginning entirely.

*sigh* Such is life, and death...

15 posted on 09/01/2014 9:02:41 PM PDT by null and void (If Bill Clinton was the first black president, why isn't Barack Obama the first woman president?)
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To: null and void

Thank you for the flag.


16 posted on 09/02/2014 3:17:00 AM PDT by Bigg Red (31 May 2014: Obamugabe officially declares the USA a vanquished subject of the Global Caliphate.)
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