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The Diabetes Dilemma for Statin Users
New York Times ^ | March 4, 2012 | Eric J. Topol

Posted on 03/06/2012 9:26:10 PM PST by nickcarraway

We’re overdosing on cholesterol-lowering statins, and the consequence could be a sharp increase in the incidence of Type 2 diabetes.

This past week, the Food and Drug Administration raised questions about the side effects of these drugs and developed new labels for these medications that will now warn of the risk of diabetes and memory loss. The announcement said the risk was “small” and should not materially affect the use of these medications. The data are somewhat ambiguous for memory loss. But the magnitude of the problem for diabetes becomes much more apparent with careful examination of the data from large clinical trials.

Statins have been available since the 1980s but their risk of inducing diabetes did not surface for nearly 20 years. When all the data available from multiple studies was pooled in 2010 for more than 91,000 patients randomly assigned to be treated with a statin or a sugar pill (placebo), the risk of developing diabetes with any statin was one in every 255 patients treated. But this figure is misleading since it includes weaker statins like Pravachol and Mevacor — which were introduced earlier and do not carry any clear-cut risk. It is only with the more potent statins — Zocor (now known as simvastatin), Lipitor (atorvastatin) and Crestor (rosuvastatin) — particularly at higher doses, that the risk of diabetes shows up. The cause and effect was unequivocal because the multiple large trials of the more potent statins had a consistent excess of diabetes.

For those statins, the higher the dose, the more diabetes, though we don’t have enough data yet to say with precision at which dose excess diabetes showed up for each drug. What we do know is that diabetes showed up. The numbers increase to one in 167 for patients taking 20 milligrams Crestor,

(Excerpt) Read more at nytimes.com ...


TOPICS: Health/Medicine; Science
KEYWORDS: cholesterol; diabetes; health; medicine; statin; statins

1 posted on 03/06/2012 9:26:12 PM PST by nickcarraway
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To: nickcarraway

It makes me test higher in the morning.


2 posted on 03/06/2012 9:47:13 PM PST by Mike Darancette (Romney just makes me tired all over.)
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To: nickcarraway

Risk of Diabetes in Patients Taking Thiazide Diuretics

http://www.mayoclinicproceedings.org/article/S0025-6196%2811%2960953-1/fulltext


3 posted on 03/06/2012 9:49:47 PM PST by Netizen (Path to citizenship = Scamnesty. If you give it away, more will come. Who's pilfering your wallet?)
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To: Mike Darancette

You mean your blood glucose?


4 posted on 03/06/2012 9:50:10 PM PST by nickcarraway
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To: nickcarraway

USE Niacin...the real stuff...NOT the NON-flushing stuff...it has been proven to be nearly as good (or better) as statins, AND, it’s cheaper. Start on a low dose and build up if you flush. The flushing won’t kill you...it’s just a little bothersome in the beginning.


5 posted on 03/06/2012 10:22:57 PM PST by goodnesswins (2012..."We mutually pledge our Lives, our Fortunes, and our Sacred Honor")
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To: nickcarraway

My doc took me off Simvastin and switched me to Crestor 2 yrs ago. My cholesterol and blood sugar levels are where they should be.


6 posted on 03/06/2012 10:51:51 PM PST by Impala64ssa (You call me an islamophobe like it's a bad thing.)
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To: nickcarraway

I have taken Pravastatin for 14 years.

I can still remember everything from 1964....Mrs Moffat’s cleavage in Music...I will die with that memory indelibly stained

but what the hell did I eat while typing 30 minutes ago?

i’ll have to look at the bowl

...hmmmm...looks like Blue Bell Chocolate fudge-Coconut

a little memory loss so i can still eat ice cream yet remember female anatomy from 50 years ago is a damned fine trade off in my way of reckoning even if I have to study my kids to remember which is which sometimes


7 posted on 03/06/2012 10:58:56 PM PST by wardaddy (I am a social conservative. My political party left me(again). They can go to hell in a bucket.)
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To: nickcarraway

No one should ever take statins period. They are killers. The reason they are prescribed is bogus. The cholesterol is harmful argument is bogus. They kill your immune system and hurt your body and mind, permanently.

http://www.doctormercola.com/cholesterol-2/the-many-dangers-of-statin-drugs/


8 posted on 03/06/2012 11:09:21 PM PST by Yaelle (Santorums 2012 - we need a STEADY conservative President)
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To: wardaddy

Why don’t you make your kids wear name tags?


9 posted on 03/06/2012 11:12:06 PM PST by nickcarraway
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To: nickcarraway

lol...that actually elicited a laff out loud in my home office

well done

i’m gonna crash on that note if I can find the bed..it’s somewhere upstairs

(just listen for wifey’s snoring)


10 posted on 03/06/2012 11:34:34 PM PST by wardaddy (I am a social conservative. My political party left me(again). They can go to hell in a bucket.)
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To: nickcarraway

Lipitor definitely contributes to memory loss that mimics dementia. Doctors have prescribed dosages that are much too high and should be cut in half, generally.


11 posted on 03/07/2012 12:28:22 AM PST by txrefugee
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To: Yaelle
No one should ever take statins period. They are killers. The reason they are prescribed is bogus. The cholesterol is harmful argument is bogus. They kill your immune system and hurt your body and mind, permanently.

Agreed. Cholesterol lowering to prevent heart disease is one of the greatest frauds foisted on the world. Triglycerides and HDL ratios are the best predictor. Further, metabolic syndrome is the primary cause of insulin resistance and the surge in endothelial inflammation. We can all thank the federal government and the food pyramid for that.
12 posted on 03/07/2012 12:41:13 AM PST by PA Engineer (Time to beat the swords of government tyranny into the plowshares of freedom.)
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To: wardaddy

Laughing is a good way to call it a night. And lowers cholesterol.


13 posted on 03/07/2012 12:43:23 AM PST by nickcarraway
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To: nickcarraway
You mean your blood glucose?

Yes, Sorry.

14 posted on 03/07/2012 6:03:40 AM PST by Mike Darancette (Romney just makes me tired all over.)
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To: goodnesswins

“USE Niacin...the real stuff...NOT the NON-flushing stuff...it has been proven to be nearly as good (or better) as statins, AND, it’s cheaper. Start on a low dose and build up if you flush. The flushing won’t kill you...it’s just a little bothersome in the beginning.”

i have been taking red rice yeast (2) and 2000mg niacin for the past year. also lost 22 pounds and exercis at least 200 minutes a week. my overall went from 241 to 183 and all my numbers are great. i take my niacin at night as i turn off the light and am usually asleep before the minor (for me) flushing starts.


15 posted on 03/07/2012 8:36:36 AM PST by bravo whiskey (If the little things really bother you, maybe it's because the big things are going well.)
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To: bravo whiskey

Doesn’t the flushing ever stop.....I take 1500 a day, and never flush anymore, unless I miss a couple doses.


16 posted on 03/07/2012 11:33:56 AM PST by goodnesswins (2012..."We mutually pledge our Lives, our Fortunes, and our Sacred Honor")
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