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Possible Stem cell treatment for Parkinson's disease from Retinal Cells
Pub Med ^ | 06.28.09

Posted on 12/20/2010 9:43:46 PM PST by Coleus

Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease

Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease


TOPICS: Health/Medicine; Science
KEYWORDS: adultstemcells; health; parkinsons; retina; retinalcells; science
human retinal pigment epithelium cells
1 posted on 12/20/2010 9:43:52 PM PST by Coleus
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To: Coleus

I wish I had not clicked the link.


2 posted on 12/20/2010 10:00:36 PM PST by allmost
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To: Coleus

Where does it say stem cells?


3 posted on 12/20/2010 10:02:00 PM PST by LibFreeOrDie (Obama promised a gold mine, but will give us the shaft.)
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To: LibFreeOrDie

Gobbledygook gets them grants. :)


4 posted on 12/20/2010 10:29:22 PM PST by allmost
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To: allmost

The poster added “stem cells” to the headline, not the scientists.


5 posted on 12/20/2010 10:31:49 PM PST by LibFreeOrDie (Obama promised a gold mine, but will give us the shaft.)
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To: LibFreeOrDie
The headline didn't fit my screen at the source. Gave the benefit of the doubt.
6 posted on 12/20/2010 10:38:29 PM PST by allmost
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To: allmost; LibFreeOrDie
This is the original article I read which led me to the Journal Articles after I googled "Human Retinal Pigment Epithelial Cells".

*Stem cell treatment for Parkinson's disease

Stem cell treatment for Parkinson´´s disease
Parkinson´´s disease is a brain disorder that occurs when certain nerve cells in the brain die or become damaged. The normal function of these nerve cells is the production of Dopamine, a vital chemical which is responsible of our body´´s smooth and well coordinated movements. The lack of Dopamine as a result of damaged nerve cells can cause the Parkinson´´s symptoms of shaking (tremors), stiffness of the muscles, freeze ups, balance difficulties and slowness of movement.

To treat Parkinson´´s disease we apply a unique procedure, specifically designed for Parkinson´´s patients, in which we implant adult stem cells extracted from the human retina, called "Human Retinal Pigment Epithelial cells"(HRPE) by injection. These special cells have the quality of producing Dopamine, which the lack of this chemical, causes the symptoms of Parkinson´´s disease.
Another important advantage of these cells is that they have no immunosuppressive reactions and therefore patients do not need to take additional drugs during the treatment.

The treatment includes the implantation of HRPE cells, along with a daily cocktail of medications that "fertilize"the damaged area, helping the cells to survive and to keep on renewing themselves.  While the treatment cannot completely remove all symptoms of the disease, it can greatly reduce the tremors, decrease muscle tension, improve continuity of movement and balance, increase muscle strength, decrease freeze ups, etc.
In June 2006 we performed the first published successful stem cell treatment for Parkinson´´s worldwide, of an American patient who came to our hospital at a very advanced stage of Parkinson´´s disease. 

So far, more than 50 Parkinson´´s patients have been treated with HRPE stem cells from Peking University´´s Stem Cells Research Center ("Beida") and various other cooperating hospitals. All of the patients showed increasing dopamine metabolism, and the conditions of all the patients improved after the transplantation (usually the improvement occurred one week after the injection). The first clinical trial was performed in 2004, but long term follow-up is still under investigation (at least 1-3 years of follow-up), so the treatment is still under careful control, especially in the selection of suitable patients. Written by Dr. Like Wu, Dr. Xiaojuan Wang

7 posted on 12/20/2010 11:38:12 PM PST by Coleus (The Immaculate Conception: O Mary, conceived without sin, Pray for us, who have recourse to Thee)
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To: Coleus
I want everything dode that can be done to alleviate Parkinsons disease. I am pre justifying this from your link-
"Rats were deeply anesthetized with chloral hydrate and sacrificed by transcardial perfusion with PBS (37°C) for 20 minutes followed by 4% paraformaldehyde (PFA) (4°C) for 10 minutes. Brains were removed, postfixed for 2 hours in PFA and then cryoprotected for 24 hours in PBS with 30% sucrose. Before frozen in -80°C, the brains were embedded in embedding medium compound (Sakura, USA). Coronal sections (10 μm) were made through the striatum containing transplants and mounted to gelatin coated slides.

I agree with that.
Your deceit with the initial headline coupled with sadistic mammal torture I cannot. You gain nothing. Sick bastards.
8 posted on 12/21/2010 1:22:15 AM PST by allmost
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To: allmost

They were anaesthetized. That’s hardly torture.


9 posted on 12/21/2010 1:27:28 AM PST by beezdotcom
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To: beezdotcom

I never said torture. You jumped the gun a bit. Don’t make up words for me please.


10 posted on 12/21/2010 1:31:42 AM PST by allmost
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To: beezdotcom

You are right. I said torture. Give me a minute.


11 posted on 12/21/2010 1:33:40 AM PST by allmost
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To: beezdotcom
I apologize. First. I disagree as well. These are rat brain cells and not human correct?
12 posted on 12/21/2010 1:35:56 AM PST by allmost
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To: beezdotcom

Are you willing to respond?


13 posted on 12/21/2010 1:49:50 AM PST by allmost
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To: allmost

Honestly, do I really still need to?


14 posted on 12/21/2010 8:27:35 AM PST by beezdotcom
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To: allmost

there was no deceit, you’re being immature.


15 posted on 12/21/2010 10:42:25 AM PST by Coleus (The Immaculate Conception: O Mary, conceived without sin, Pray for us, who have recourse to Thee)
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