Posted on 10/15/2020 5:38:38 PM PDT by amorphous
President Trump taking zinc (WSJ)
https://www.wsj.com/articles/trump-ta...
Low zinc levels at clinical admission associates with poor outcomes in COVID-19, (11th October)
https://www.medrxiv.org/content/10.11...
Zinc balances immune responses and also has a proven direct antiviral action against some viruses.
Zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases
Increased intracellular zinc concentrations efficiently impair replication
Resulting in a lower number of viruses
Retrospective analysis
Patients admitted in Barcelona
15th March to 30th April 2020
Clinical severity of COVID-19 and PMH assessed
Fasting plasma zinc levels measured routinely at admission
N = 611
Mean age, 63 years
Male 332, (55%)
Total mortality was 87 patients (14%) during study time
But
249 of 611 patients studied
Of the 249, 21 (8%) died
Baseline zinc levels
Died, (21 people) mean plasma zinc = 43 μg/dl
Survived, (228 people) mean plasma zinc = 63.1 μg/dl
Higher zinc levels, associated with lower maximum levels of interleukin-6 during the period of active infection
Zinc level lower than 50 μg/dl at admission, 2.3 times increased risk of in-hospital death
Compared with those of 50 μg/dl or higher
Lower zinc levels at admission correlate with higher inflammation in the course of infection and poorer outcome
Low plasma zinc levels at admission are associated with mortality in COVID-19 in our study
Further studies are needed to assess the therapeutic impact of this association
COVID-19: Poor outcomes in patients with zinc deficiency (International Journal of Infectious Diseases, November 2020)
Chennai, India
Prospective study of fasting zinc levels in COVID-19 patients at the time of hospitalization
Healthy controls median 105.8 μg/dl
https://www.sciencedirect.com/science...
Zinc is a trace element with potent immunoregulatory and antiviral properties
Is utilized in the treatment of coronavirus disease 2019 (COVID-19)
Patients with serious COVID-19 had significantly low zinc levels in comparison to healthy controls
Zinc deficient COVID patients developed more complications
Zinc deficient patients 70.4% developed complications
Non zinc deficient patients, 30.0% developed complications, (p = 0.009)
Acute respiratory distress syndrome
More need of steroids
Increased mortality
Zinc deficient COVID patients had a prolonged hospital stay
Zinc deficient patients, 7.9 days
Non zinc deficient patients, 5.7 days, (p = 0.048)
In vitro studies
Reduced zinc levels increase SARS-CoV-2 virus receptor interactions
Increased zinc levels inhibit ACE2 expression
https://ods.od.nih.gov/factsheets/Zin...
What zinc does
Catalytic activity of approximately 100 enzymes
Plays a role in immune function
Protein synthesis
Wound healing
DNA synthesis
Cell division
Normal growth and development, pregnancy, childhood, adolescence
Required for sense of taste and smell
Zinc and immunity
Severe zinc deficiency depresses immune function
Even mild to moderate degrees of zinc deficiency can impair macrophage and neutrophil functions, natural killer cell activity, and complement activity
Body requires zinc to develop and activate T-lymphocytes
Low zinc levels have shown reduced lymphocyte proliferation
…. that can be corrected by zinc supplementation
Low zinc status has been associated with increased susceptibility to pneumonia and other infections in children in developing countries and the elderly
Foods Oysters Sea food Beef Pork Baked beans Fortified cereals Pumpkin seeds Yogurt Cashew nuts Chickpeas Oats Almonds
Vitamin D and zinc can be made in bulk for essentially nothing
I’ve been on this protocol since April
Prophylaxis
While there is extremely limited data, the following “cocktail” may have a role in the prevention/ mitigation of COVID-19 disease. This cocktail is inexpensive, safe, and widely available. It should be noted that a recent publication suggests that melatonin my reduce the risk of COVID-19 infection, while many papers suggest that Vitamin D deficiency increases the risk of infection and is associated with a significantly worse outcome.
• Melatonin (slow release): Begin with 0.3mg and increase as tolerated to 2 mg at night
• Vitamin D3 1000-3000 u/day. Note RDA (Recommended Daily Allowance) is 800-1000 u/day. The safe upper-dose daily limit is likely < 4000 u/day.
• Vitamin C 500 mg BID (twice daily) and Quercetin 250 mg daily Note that prolonged high dose quercetin has very rarely been associated with hypothyroidism. should be used with caution in patients with hypothyroidism and TSH levels should be monitored.
• Zinc 50-75 mg/day (elemental zinc). After 1 month, reduce the dose to 30-50 mg/day.
• Famotidine 20-40 mg/day
Hmmm, maybe that’s why I’m so healthy, all those zinc rich foods are my favorite foods. Also, living in Arizona I get plenty of Vitamin D
.
Bttt
Don’t forget Quercetin....eat plenty of onions!:)
I've seen it reported Quercetin helps with the intake of zinc into cells. I take 800 mg every third day or so. I take 5,000 IU of D3 with K daily. I believe the safe level for D3 is 10,000 IU or less for those who don't get many rays?
That’s where I fail, I hate onions.
Vitamin D3 dosage a little low, I think to prevent idiots from overdosing. Vitamin D toxicity definitely messes with calcium metabolism
P4L
I take 200% plus of zinc and D3 every day.
CC
It does affect calcium metabolism. That’s why I look for a D3 supplement which contains vitamin K. Vitamin K helps with getting the calcium to the right places in the body. Vitamin K is found in green vegetables like Spinach. Too much vitamin K can cause the blood to coagulate too well.
Pepcid is cheap
... Too much vitamin K can cause the blood to coagulate too well.
Which is potentially a problem with COVID associated intravascular clotting events
Too much zinc can cause issues. Taking a little copper helps to offset this, I understand.
Yep. I add a single aspirin daily to my regimen if I feel like I’m coming down with something.
Maybe cheap, but what are the side effects? I understand taking it daily if you have heartburn, etc., but a better plan for antihistamines might be to wait for the onset of symptoms?
Had to add asa this week, asymptomatic COVID + test... currently hiding in basement, wife (-) and I would like to keep it that way.
“ Vitamin D3 1000-3000 u/day. Note RDA (Recommended Daily Allowance) is 800-1000 u/day. The safe upper-dose daily limit is likely < 4000 u/day.”
...
I’ve taken at least 5,000 units of D3 per day for a decade or more.
My doctor tested my d levels and told me I was the only person he ever tested who had adequate levels.
In winter, I take 10,000 units daily.
If I get the flu I follow the vitamin D hammer, taking 35,000 for each of 3 days. Knocks out symptoms and ends it.
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