Groundbreaking study identifies two bacteria in the gut that trigger MS

expose-news.com ^ | August 5, 2025 | Rhoda Wilson, Dr. Jessica Rose

[ransomnote]

A groundbreaking study published in PNAS has identified two gut bacteria as triggers for Multiple Sclerosis (“MS”).

The study involved 81 pairs of identical twins, where only one sibling had MS, and found that these bacteria were consistently linked to MS.

The researchers transplanted gut microbes from MS-affected twins into germ-free mice, which developed MS-like symptoms, establishing a causal link between the bacteria and the disease.

A New Multiple Sclerosis Study Is Actually Ground-Breaking

By Dr. Jessica Rose, 29 July 2025

A study was published on 21 April 2025 in PNAS entitled ‘Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice—An unbiased functional study’.¹ Strategic identification of gut bacteria functionally linked to the development of multiple sclerosis (“MS”) is no small feat and this is precisely what the authors have done.

This study is designed really well and has excellent controls and actually causally links two specific gut bacteria called Eisenbergiella tayi and Lachnoclostridium are “likely responsible for an increased incidence of disease.” They are both really important to gut metabolism. Wikipedia calls Lachnoclostridium “obsolete” for some reason.

On Multiple Sclerosis

Multiple sclerosis (MS) is an autoimmune disease resulting in damage to myelin – the insulating covers of nerve cells – in the brain and spinal cord.²

Over 1 million Americans suffer from MS and it can be quite debilitating depending on the degree and location of demyelination (damage to myelin). It is an autoimmune disease (the body’s immune cells (T and B) attack myelin), characterised by the formation of lesions or “plaques” in the central nervous system (“CNS”), inflammation and destruction of neuronal myelin sheaths.

MORE AT THE LINK: https://expose-news.com/2025/08/05/two-bacteria-in-the-gut-that-trigger-ms/ 

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TOPICS: Miscellaneous
KEYWORDS: bacteria; begonefoultrolls; bionicseamonkeys; garbagesource; garbagetroll; gitract; gutbacteria; ms; randomnut; tcoyh

[ConservativeMind]

I would think other bacteria could outcompete it.

Probiotics with prebiotics would be a great start.

[ComputerGuy]

Amazing if it stands up.

[JeemBeau]

I wonder if any differences in the diets, lifestyles, or locations between the twins can be found to cause the presence of these gut bacteria, or in having higher immunity against acquiring the bacteria..

[Bayard]

An actual cure for MS would be a great service to mankind.

[Myrddin]

My sister posted an article about Parkinson's last week. There is a protein named PINK1 responsible for causing "mitophagy" to occur. When mitochondria become worn, they are triggered to die by PINK1. When the gene coding for PINKT is defective, the mitophagy doesn't occur and the defective mitochondria stick around creating poisons that damage the dopamine creating cells.

Scientists unveil how key protein malfunctions and leads to Parkinson's

[Myrddin]

Why does this remind me of the once “Settled Science” of stomach ulcers?

I ran into an article today that makes the case that most stomach cancers are due to untreated H. pylori infections. H. pylori is also identified as the cause of stomach ulcers.The treatment plan is not a simple nuking with antibiotics that wipe out the microbiome.

[NoLibZone]

As long as it’s not from pop tarts and beef jerky, I’m cool.

[KittyKares]

That’s quite a discovery. I hope it will help find a treatment which will cure all the people with MS out there.

[ProtectOurFreedom]

I’m sure the researchers are digging into all those factors and more in a lot of detail.

[grey_whiskers]

Would you happen to have a link handy for your H. pylori article, please?

[SisterK]

I would like to see an Ivermectin vs. MS study

[Myrddin]

H. pylori post on X

[Windcatcher]

I sure hope so. I used to bike for MS. For ten years I rode the MS 150 from Cherry Hill, NJ to Ocean City, NJ.

[Myrddin]

H. pylori post on X

source article

[KittyKares]

I used to bike for MS.
____________________________________________

How good of you! Maybe this study was paid for by some of the funds you raised over the years.

[combat_boots]

So sorry

[ProtectOurFreedom]

Thank you.

[TheThirdRuffian]

Had a long discussion with the wife (Dr. TheThirdRuffian) about your point as it makes sense to me. She actually went down a hard rabbit hole on this researching hard as a result. (She’s an ER doc and deals with lots of things, including gunshots in ALBQ.)

I’m going to butcher this, but the two bacteria identified are quite small, even for bacteria. They are also present in people in their intestines who have no problems. But they cause sepsis and lots of things when in the blood because they slipped from intestine to the “inside” space that is supposed to be closed off.

They don’t particularly generate waste products that would be harmful while sitting inside your intestines, so it’s unlikely just being inside a healthy gut is the problem.

The working theory is these bacteria somehow get from the intestines where they are to the “inside inside” (her dumbing down words for this engineer) either due to illness, injury, or dumb luck. They may even be able to penetrate the intestinal wall due to being small and the genome of their coating.

Anyway, they get into where they don’t belong, triggering disease. Sometimes this can be “mild” and “chronic” (MS) or sometimes this can be acute and deadly (sepsis).

So she postulates that good gut flora would be preventive (the out compete approach), but once causing problems have to be killed (antibiotics).

She can’t find anyone who reports where the bacteria reside when causing chronic problems. Probably the intestine itself, but no one really knows.

She said the next step will be biopsies of people who died with MS to hunt for the DNA of the bacteria in various likely tissues, so they can figure out what antibiotics will penetrate those tissues and kill them.

She was particularly worried the sneaky bastards find their way into bone marrow.

[HereInTheHeartland]

“ Big Ag to quit destroying gut biomes with what passes for food these days.”

Wrong.
Our agriculture produces the safest and most affordable food supply in history .

[grey_whiskers]

Thanks Myrrdon!