[grey_whiskers]

Q. What are we going to do tonight, Brain?
A. The same thing we try to do every noght Pinky —TRY TO TAKE OVER THE WORLD!

[HartleyMBaldwin]

They employed a delivery system using adeno-associated virus serotype 9 (AAV9)—a harmless virus modified to carry genetic material into cells. This allowed mice to continue producing the protein long-term after just one treatment.

Gee, what could go wrong?

[montag813]

* Mice treated with Klotho protein lived up to 20% longer than untreated mice, which would be like extending human life from 80 to 96 years

Mice aren't people.

[Bob434]

from amazon customer

” Discovered in the 1990s, research indicates that klotho proteins may strengthen cognitive functions: with elevated klotho levels linked to prolonged lifespan and enhanced brain health. “

https://shorturl.at/6RAZJ

(link is to amazon product for klotho

[ProtectOurFreedom]

Female mice developed unrelated health problems (ulcerative dermatitis and anal bleeding) that prevented complete lifespan analysis in this sex. -- Uh huh. Unrelated.

The dual injection approach used would be challenging to implement clinically. -- "Don't move. This brain injection won't hurt a bit."

Sample sizes for some analyses were small (n=3-4 for some histological assessments). -- If n=3-4 was good enough for COVID, it's good enough for the Fountain of Youth.

[budj]

Thanks, I’ll quit feeding protein to the rats.

[Georgia Girl 2]

Of course this will never be made available to the public. 🙄

[If You Want It Fixed - Fix It]

And it grows in my field here in Florida. Wanna buy it before demand skyrockets?

[TangoLimaSierra]

I thought this was Klotho.

[Honorary Serb]

New!

https://en.wikipedia.org/wiki/Klotho_(biology)

[Dead Corpse]

https://en.wikipedia.org/wiki/Klotho_(biology)

Interesting... Wiki suggests that there has been some limited primate testing and that this does translate up from mice, although the novel part of this approach is using a benign virus as a delivery vector.

They are also experimenting with LPN (lipids, fats) as a membrane soluable delivery system.

The interesting part for me is the novel recoding of the affected gene sequence to turn klotho production on.

Not just an anti-aging treatment... this also has implications for kidney disease and geriatric cognitive impairment.

Color me intrigued.

[Nervous Tick]

I think, therefore I need steak. Or bacon, I guess.

[SunkenCiv]

Cool, they named it from Greek mythology.

[Ancesthntr]

This information about Klotho is not new. Do a search on YouTube, and you can find many videos on this going back more than a year. Here is one video that I like, and it even shows how to increase Klotho naturally (hint: exercise, emphasis on resistance training over endurance, but both work): https://youtu.be/4xQ1D-0vj4M?si=MbY8vZrchotAWeck

[dfwgator]

I saw this movie...

[E. Pluribus Unum]

https://www.klotho.com/

[mac_truck]

The research team used gene therapy to deliver Klotho

No thanks...

[Colorado Doug]

Great! That’s all we need. Mice living longer. It’s hard enough to get rid of them as it is. Sheesh!

[HKMk23]

This goes nowhere good.

https://www.sdfo.org/gj/stories/flowersforalgernon.pdf

P.P.S. Please if you get a chanse put some flowrs on Algernons grave in the
bak yard

[aimhigh]

There goes the solvency of the Social Security fund.