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Young boy dies in trial for Pfizer Duchenne gene therapy
Stat News ^ | May 7, 2024 | Jason Mast

Posted on 05/07/2024 1:12:50 PM PDT by Angelino97

click here to read article


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To: Angelino97

more mRNA meds? Did it contain CRSPR to edit his DNA? We’ll never know. Must have died from global warming


21 posted on 05/07/2024 1:51:30 PM PDT by BigFreakinToad (Remember the Biden Kitchen Fire of 2004)
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To: jimwatx

You just replied that the shot killed him having no intimate information beyond what was provided.

Chances are that may be the case, it is hardly a certainty.


22 posted on 05/07/2024 1:57:48 PM PDT by Freest Republican
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To: The Louiswu

People even died from variolation - but far fewer than from small pox.


23 posted on 05/07/2024 1:57:52 PM PDT by Jamestown1630 ("A Republic, if you can keep it.")
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To: Angelino97

Hi.

It would be interesting to see the autopsy report from the coroner.

5.56mm


24 posted on 05/07/2024 2:02:22 PM PDT by M Kehoe (Quid Pro Joe and the Ho have got to go. )
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To: Jamestown1630

“In my experience, some people here don’t care whether one was against the mandate despite choosing to take the vaccine oneself. If you took it and admitted it, they call you everything from a shill for the drug companies to undercover ‘deep state’.”

Sanctimonious blowholes who give themselves cutesy names and act exactly the opposite of actual conservatives.


25 posted on 05/07/2024 2:03:51 PM PDT by Magic Fingers (Political correctness mutates in order to remain virulent.)
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To: Angelino97

Pfizzzler


26 posted on 05/07/2024 2:07:52 PM PDT by cp124 (Bring back the Constitution.)
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To: skr
Opting into a drug trial is not remotely the same as being mandated into one.

Ditto that

27 posted on 05/07/2024 2:25:18 PM PDT by ChildOfThe60s ("If you can remember the 60s....you weren't really there")
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To: Angelino97

I work in gene therapy. Some work. Others don’t. My take is that the article is irresponsible for suggesting the therapy killed the patient. Sadly, sometimes the patients pass.


28 posted on 05/07/2024 2:29:30 PM PDT by kpbruinfan (Jesus Christ is the only name by which man can be saved.)
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To: jimwatx

Not everything Pfizer does uses mRNA. This therapy uses a viral vector to deliver the correct gene material and it’s an infusion from an IV bag, not a shot.


29 posted on 05/07/2024 2:48:16 PM PDT by Valpal1 (Not even the police are safe from the police!!!)
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To: Nateman

Because other creatures don’t get human genetic syndromes.


30 posted on 05/07/2024 2:49:53 PM PDT by Valpal1 (Not even the police are safe from the police!!!)
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To: Valpal1

Even if they use a viral vector they are most likely still using the lipid nanoparticle carrier and the n methyl pseudo uridine to make the inserted RNA last longer. Both of these were causing the problems in the mRNA covid vaxx.


31 posted on 05/07/2024 2:57:36 PM PDT by jimwatx
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To: jimwatx

It’s DNA not RNA. I see no reason that they would need to use substances developed for RNA when doing DNA gene therapy which has been around a lot longer and has nothing to do with the immune system or vaccination.

You sound a little nuts.


32 posted on 05/07/2024 3:13:40 PM PDT by Valpal1 (Not even the police are safe from the police!!!)
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To: kpbruinfan

It is a fascinating field. They just approved a gene therapy in 2024 for people who have Thalassemia that have to have blood transfusions. I only have the minor version so no transfusions needed.

There is scant info out there but I have seen studies talking about how having even Minor Thalassemia can make you more susceptible to other disorders like Diabetes. Some think it is the location of the gene. There are other theories.

So far no Diabetes for me but a few of other weird and rare disorders.

If any of you have Antisynthetase Syndrome
“CD19-Targeting CAR T Cells for Myositis and Interstitial Lung Disease Associated With Antisynthetase Syndrome”
https://pubmed.ncbi.nlm.nih.gov/37367976/


33 posted on 05/07/2024 3:32:40 PM PDT by RummyChick ( )
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To: Valpal1

The article as posted didn’t mention whether it was RNA or DNA. I would imagine they would still use the lipid nanoparticle carrier for both since that was used to assist the RNA/DNA getting past the cell wall and into the ribosomes for RNA or into the nucleus if they used DNA.

Toxicological profile of lipid-based nanostructures: are they considered as completely safe nanocarriers?

” Due to unique physicochemical properties, they are able to cross many barriers, which is not possible for traditional drugs. Nevertheless, exposure to NPs and their following interactions with organelles and macromolecules can result in negative effects on cells, especially, they can induce cytotoxicity, epigenicity, genotoxicity, and cell death.”
https://pubmed.ncbi.nlm.nih.gov/32053030/


34 posted on 05/07/2024 3:53:43 PM PDT by jimwatx
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To: jimwatx

I actually looked it up as I have always been interested in all things genetic. They are using a viral vector as the cellular delivery system.

Basically infecting the entire body with a functional gene to counteract the failings of the incomplete damaged gene.

I don’t think the nanoparticles have the right vectoring characteristics for such a systemic whole body treatment.

Gene therapy is a completely different science than vax development.


35 posted on 05/07/2024 4:15:59 PM PDT by Valpal1 (Not even the police are safe from the police!!!)
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To: Valpal1

Don’t we use humanized mice for some human genetic issues?


36 posted on 05/07/2024 4:17:45 PM PDT by Jamestown1630 ("A Republic, if you can keep it.")
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To: Jamestown1630

Humanized mice are mostly just used for testing and initial trials.


37 posted on 05/07/2024 4:27:16 PM PDT by Valpal1 (Not even the police are safe from the police!!!)
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To: skr

A tiny child chose to opt in?


38 posted on 05/07/2024 4:31:19 PM PDT by dforest ( )
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To: Valpal1

Thanks; that’s what I meant. Nateman asked if this sort of therapy wasn’t tested on ‘creatures’ first.

(Not that animal testing would necessarily always prove safety in humans...)


39 posted on 05/07/2024 4:35:28 PM PDT by Jamestown1630 ("A Republic, if you can keep it.")
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To: Valpal1

He is nuts and a raving antisemite.

Probably just a chaos troll.


40 posted on 05/07/2024 4:38:34 PM PDT by ifinnegan (Democrats kill babies and harvest their organs to sell)
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