Posted on 03/17/2024 6:50:09 PM PDT by Fractal Trader
Can Viagra prevent or reverse Alzheimer’s disease? Older men’s ship may be coming in. New research from the Cleveland Clinic suggests the erectile-dysfunction drug could ward off cognitive decline, illustrating how artificial intelligence can help scientists repurpose old medications for new diseases.
The study, published this month in the Journal of Alzheimer’s Disease, builds on earlier research by the Cleveland Clinic that identified sildenafil, the generic name for Viagra, as a promising Alzheimer’s treatment.
Researchers first identified genes associated with the disease’s pathology, amyloid plaque and tau tangles in the brain. They then mapped out the molecular interplay among more than 1,600 drugs already approved by the Food and Drug Administration and Alzheimer’s-related proteins. After identifying 66 medications that interact with Alzheimer’s genes and pathology, they settled on sildenafil as the one with the most potential.
As a next step, they analyzed insurance claims from more than seven million Americans. They found that people who took sildenafil were 69% less likely to develop Alzheimer’s than those who didn’t after adjusting for sex, age and other diseases. Correlation doesn’t prove causation, but further study suggested they might be on to something.
Researchers grew neurons from the stem cells of Alzheimer’s patients in test tubes and exposed them to sildenafil. What do you know? The drug increased brain cell growth and decreased toxic tau, which usually develops in the early to middle stages of the disease. This suggested possible mechanisms by which sildenafil might arrest the disease.
In their new study, Cleveland Clinic researchers analyzed two patient databases and found that those who took sildenafil were 30% to 54% less likely to be diagnosed with Alzheimer’s. They also found that sildenafil activated genes in neurons that are associated with cell growth, improved brain function and reduced inflammation.
(Excerpt) Read more at wsj.com ...
Who can see how stupid this ‘revelation’ is?
(Reminder: Viagra effects vasodilation, and not exclusively in the tripod organ)
I swear: Every single day demonstrates that we are closer to true Idiocracy.
And as a footnote: They still can’t figure out what causes dementia etc...
I wonder if they’ve considered the obvious-sex is good for you and the men taking it would most likely being having more sex?
Thanks for ruining the good vibes in my nether region.
That’s “The Biden Warning”
It had best also help you remember WHO the F you’re supposed to “do”.
Pulmonary Hypertension
2 viagra, 2 aspirin, 2 beta blockers, 2 Lipitor, and 2 oxycodone tablets every day. You will love to 100. And live to 110.
You are correct. All the drugs of this class have similar effects on blood flow in the brain and in the heart. That helps clean out the pipes in both the brain and heart. Improves vascular condition throughout the body over time.
Well then I’m f$$king Werner Heisenberg
High altitude guys often take cialis to help with lower O2 levels
Back in my day it was 1 whiskey, 1 shot and 1 beer.
You millennials and your pharmaceuticals.
now its used to make old or middle age men feel like they're much younger...instead of accepting that as you grow old, nothing works as well as it used to, but women are the vain ones supposedly.....
Only to help find north.
What about us retired widows in senior living ? Are we in danger of constant harassment from the lonely widowers chasing us down the hallways?
What defense is politically acceptable, or do we have to hire our grandsons to protect our elderly honor?
Good news for women attracted to intelligent older men.
LOL.
I’m a woman, what the heck would viagra do to me? I may be sorry I asked, but thee you are.r
Don’t ever take Viagra with Rogaine. It will make your hair stand on end.
“ Good news for women attracted to intelligent older men.”
Better news for men stuck with old run down wives
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