Posted on 12/03/2023 10:39:29 AM PST by ConservativeMind
A study has shed light on the complex relationship between serum lipids, lipid-modifying targets, and cholelithiasis, a common condition characterized by the formation of gallstones. The study employed a combination of observational and Mendelian randomization (MR) approaches to comprehensively assess these associations.
Cholelithiasis is a prevalent hepatobiliary disorder that primarily affects Western populations. It is a significant risk factor for cholangiocarcinoma, a type of bile duct cancer. Understanding the factors influencing cholelithiasis risk is crucial for developing effective prevention and treatment strategies.
Previous research has explored the role of serum lipids and lipid-modifying targets in cholelithiasis development. However, findings have been inconsistent, highlighting the need for further investigation. The current study aimed to address this gap by conducting a comprehensive analysis of these relationships.
The study utilized data from the UK Biobank, a large-scale biobank resource, to examine the associations between serum lipids (total cholesterol, LDL-C, HDL-C, and triglycerides) and cholelithiasis risk. The researchers found that serum LDL-C and HDL-C levels were inversely associated with cholelithiasis risk, indicating that lower LDL-C and higher HDL-C levels were associated with a reduced risk of gallstone formation.
Interestingly, the relationship between serum total cholesterol and cholelithiasis was non-linear, with lower cholesterol levels associated with an increased risk of gallstones. This finding contrasts with conventional wisdom, which suggests that lower cholesterol levels are generally beneficial for health.
The researchers also employed MR, a genetic approach, to investigate the causal effects of serum lipids and lipid-modifying targets on cholelithiasis risk. MR utilizes genetic variants as proxies for specific risk factors, allowing for assessing causal relationships without the confounding effects of lifestyle and environmental factors.
MR analyses supported the observational findings, confirming that lower serum total cholesterol and higher triglyceride levels were independent causal risk factors for cholelithiasis.
(Excerpt) Read more at medicalxpress.com ...
1. High LDL and low HDL
2. Low total cholesterol and higher triglycerides
From the study:
“Lower serum TC can causally increase the risk of cholelithiasis. The cholelithiasis risk would increase with the elevation of serum TG but would decrease when exceeding 2.57 mmol/L. The use of HMGCR inhibitors should prevent its risk.”
“HMGCR inhibitors” seem to simply be normal statins, which, strangely, help get total cholesterol to low amounts.
You’d think statins helped make the problem, if total cholesterol was too low, with their use. It would seem best to not get your cholesterol levels “too low,” with, or without statins.
thanks.
My ldl/hdl as of last measurements in september were 47/48 vldl 9 triglicerides 43.
I have been trying to lower ldl and increase hdl and lower vldl and triglicerides.
Looks like I made them too low and opened myself up for gall stones.
Now I don’t know what is a safe range for any of them except that its best to have higher hdl.
this article seems to go against conventional wisdom.
I googled “What is the main cause of cholelithiasis?”
The answer came from Johns Hopkins.
What are gallstones? Gallstones form when bile stored in the gallbladder hardens into stone-like material. Too much cholesterol, bile salts, or bilirubin (bile pigment) can cause gallstones. When gallstones are present in the gallbladder itself, it is called cholelithiasis.
Cholesterol below 60 promotes cancer.
Above 300, heart disease.
Choose.
THIS! Stop trying to lower cholesterol.
The only “bad” cholesterol are dead ones, known as “compact” LDL (cLDL). Robust real cholesterol are required for health.
When livers glycate through fructose and alcohol ingestion they stop filling cholesterol shells with ingested fat products (triglycerides). The results are elevated blood triglycerides and cLDL particles, and lowered healthy cholesterol.
Cholesterol typing is useless. Proportions are determined by genetics, and have no bearing on health.
you mean total ldl/hdl or total ldl/hdl/vldl/triglycerides
this johns hopkins recommendation has upper limits for ldl/hdl and triglycerides
But no lower limits
exception for lower limits is hdl. you want to keep that above 40.
FYI, FWIW . ...
A few months ago I had a gallstone episode. On the advice of a Naturopath I wrapped a castor oil pack on the area and applied a heating pad.
It took a few hours but I actually felt the stones move and flush out, and the pain was gone.
A little bit later the stones made their final appearance and said goodbye.
Castor oil packs are pretty interesting for a variety of ailments.
Yes, you would prefer HDL being higher.
Of course they do.
Coins in allopathic medicine only have one side - just like their research.
:-)
Cholesterol below 60 promotes cancer.
Above 300, heart disease.
Choose.
///////
Do you mean total ldl and hdl? or do you mean total ldl/hdl/vldl/triglycerides
Some items for your consideration:
“Your body will naturally put the LDL in a 120 to 160 range and make it fluffy if you keep off the bad oils and cheap carbs.”
[Fluffy “beachball like” LDL is what you need to transport hormones - small particle size results from bad oils and cheap carbs.]
Here is what I was trying to quote from memory...
“Additionally, it has been shown that CAD progresses when the LDL is over 180
and cancer progresses when the LDL is under 100.”
“So given this fact, why lower LDL and risk cancer due to the lack of hormones.” [LDL transports hormones]
“If one manages the intake of cheap carbs and bad fats, the LDL automatically falls into the good range of 110 to 180 and HDL jumps to between 65 and 85.
“It appears to be that simple. From the author’s own experience, this holds to be true. I have the tests to prove it.”
Quotes from the two articles on this site:
https://www.k-vitamins.com/index.php?page=research-view-all&id=18
best
I take the concentrated K with vitamin d.
I only started about a month ago after Conservative made a post about it.
I’m hoping that that will increase my HDL above it current 48. But have to say I have never broken 50 with HDL. And I have been off the carbs sugars and bad fats for a couple years now.
So there has to be genetic component to it.
For example I’ve read about with very high ldl levels who were in great shape because their hdl levels were very high too.
My understanding currently is that what’s important is the ratio betwee hdl and ldl. You want to get them close to 1:1 or 2:1 if you can.
I crestor for a statin—not so much because it lowers ldl but because it lowers inflammation.
What I have read in
I avoid statins because they deplete co q10 and the body needs sufficient cholesterol to coat nerves, etc. LDL is not “bad” - Gid made it for your body to use.
Also, if you’ve not read his story carefully, note what happened when he stopped statins.
Best.
https://clermontherbshoppe.com/how-to-increase-bile-flow-naturally-for-better-health/
there’s good info here, especially about the correlation of low thyroid and low bile. We need to get our stomach acid UP as well which promotes bile production.
I take the coq with a very low dose. 5mg crestor.
I take all the supplements suggested
I’m not sure that I’ve heard you want your ldl to be in the 120 range—because ldl carries the vitamins k,d,a on its surface. ldl was 120 for me until I crashed it with the crestor. There’s another book I’m reading on the subject. They may have said the same thing. If so, I’ll go off the crestor.
Three hours of high intensity exercise a week to raise your hdl by 20 points. yikes. When I’m on a roll, I do maybe as much as an hour a week of HIIT exercise. That’s a good week for me.
woof.
If my LDL is ~180 or less, I’m happy.
PS - not an MD, but a health researching human.
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