Posted on 10/18/2023 9:34:37 PM PDT by ConservativeMind
A new study has identified a compelling link between vitamin B12 deficiency and chronic inflammation, which is associated with a range of health problems including cardiovascular disease, diabetes, and neurodegenerative disorders.
The research examined the effects of circulating B12 concentration on the levels of two key inflammatory markers in both humans and mice.
Vitamin B12, an essential nutrient with roles in various physiological processes, is known to be critical for overall health. Its deficiency can be the result of dietary insufficiency or inefficient absorption in the body. This can lead to a range of complications, including neurological disorders. While previous research has hinted at the potential anti-inflammatory properties of vitamin B12, the precise relationship is not fully understood.
Now, researchers have investigated the effects of vitamin B12 on the levels of two molecules in the body which promote inflammation, specifically interleukin (IL)-6 and C-reactive protein (CRP).
Rosa M. Lamuela-Raventós explained the motivations behind the study.
"Establishing the relationship between inflammatory markers like IL-6 and CRP [and vitamin B12 levels] could have direct clinical relevance and open doors to novel therapeutic strategies."
The study utilized samples from a randomized subsection of participants in PREDIMED, a large clinical trial, designed to assess the effect of the Mediterranean diet on the primary prevention of cardiovascular disease. An assessment of the serum levels of vitamin B12 and the concentrations of the inflammatory markers revealed a correlation between the two.
"Our study found that in general, the more vitamin B12 an individual has, the lower their inflammatory markers are—we call this an inverse relationship," explained Marta Kovatcheva.
The study also observed the same relationship between vitamin B12 and inflammatory markers in naturally aged mice, offering a valuable avenue of using mouse models to delve deeper into the underlying mechanisms of the inverse correlation.
(Excerpt) Read more at medicalxpress.com ...
Chuck,
In your report on your condition you mention nerve regrowth. I will advise some that nerve death in extremities due to low B-12 and chemo often leaves damage to the extent that there is no regrowth or regeneration.
A lot of money gets wasted trying to bring regrowth or restoration about. I have had such nerve damage for four years and extensive tests by neurologists. As my stomach was removed it produced Intrinsic Factor which is required for B-12 levels to be sufficient. I now take daily large B-12 supplements but B-12 absorption is tricky and just the minimum RDA won’t due it with a gastrectomy.
I’ve been having some eyelid twitching. I was telling my hubby that I thought I needed to see a doctor. He suggested taking B12. My eyelid hasn’t twitched since I started taking it.
Nerves are tricky things, we don’t notice them until one or two start acting up then all hell can break loose. My whole Giant Cell Arteritis began with a month long case of Bells Palsy. Cranial nerve #7 decided to get mad and inflamed and my face went all droopy for a month. It’s weird that the Docs still don’t know why this happens or what to really do for it, same with my GCA. For now the treatment is Prednisone and constant checking of my hs-cRP levels.
Good luck on your health journey, it sounds a bit more serious than mine at the moment. This getting old is for the birds. Shit just starts popping up out of nowhere. I was watching my favorite Bengals in the playoffs last year in January, and that day was the start of my headaches that wouldn’t go away. I couldn’t have been more relaxed, in a good mood and all that, yet down inside my body was boiling with inflammation and I had no clue. The docs and I still have no clue as to why it happened either, that’s the frustrating part.
.
Here’s another article I came across the other day, discussing how eating less calories helps the body with muscle strength and helps inflammation.
Calorie restriction in humans builds strong muscle and stimulates healthy aging genes
Have you seen any numbers as to optimal b12 per age group.
Characteristics Normal B12 Levels
Adult male and female 200 pg/ml to 900 g/ml
0-1 year (Male) 227 pg/ml to 1500 pg/ml
0-1 year (Female) 292 pg/ml to 1202 pg/ml
13-18 years (Male) 181 pg/ml to 817 pg/ml
13-18 years (Female) 213 pg/ml to 860 pg/ml
As I have no Intrinsic Factor due to Stomach removal, I have to take supplements and due to nerve damage from Chemo have been told that 300 pg/ml is my minimum to maintain.
Good morning FRiend,
I have sent you a PM. Looking forward to hearing from you.
I have a continual low grade pain in my left wrist. would a b12 injection help that? If so where would you inject it.
I have a constant low grain pain in my wrist. would a b12 injection help that? If so where would you inject? on the top bottom left or right?
You might also check out niacinamide, which is B3, and is taken in pill form. I have a family member who tried it for joint pain in the hip and it has been very effective.
Do not inject directly into a wrist or any location of pain. B12 works within the bloodstream. Inject B12 into the muscle of the upper arm or into a thigh. It will be absorbed into the bloodstream and from there work its magic.
I do not know the mechanics of action.
I do know that oral B12 requires intrinsic factor, located within the stomach, to be absorbed. As we grow older, intrinsic factor becomes less or non-existent. That is why many, like me, must inject it.
I am not a physician. I am not a medical authority. I am only sharing what I do for me. Individuals are responsible for researching and gaining their own knowledge.
what dosage?
at the direction of a holistic dr I was seeing, they recommended the injection into the shin
check out this excellent book on B12 deficiency:
“Could It Be B12: An Epidemic of Misdiagnoses”
Thanks for explaining the procedure and your recovery pattern. Sounds like you received excellent care.
My local health food store has a B-12 injection clinic every Saturday and they are always busy, check around your neighborhood health food stores. Last time I went I think it cost $25 or $30. I was wired the whole day and next. Felt good. Lots of drunks go get them and bikers for some reason.
You’re welcome, I have indeed had good care, except for my GP who was stumped. He had me do MRI and a full body and head CAT which were negative, ( did find out I have some gallstones), he didn’t know what to do so I went to the Neuro center and they figured it out right quick. Again, it was the CRP blood test, and the ESR sediment rate blood test that really set the Dr off on GCA. Only the biopsy would confirm. He was right and he he scared me to death when he called me, he said, “go to pharmacy right now, I have called them and you need prednisone immediately, 60mg, go get it and start right now or you can go blind. Don’t stop taking it until I tell you to.” So thats what I’ve been doing, I’m now on a long slow taper down from the 60mg prednisone, once I get to 10mg I will taper 1mg a month for 10 months with monthly blood test to check CRP and ESR levels. If they go up, my prednisone goes back up. If my numbers stay down I will be considered in remission.
Thanks!
Sorry, I don’t know.
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