Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

Powerful new obesity drug poised to upend weight loss care
AP ^ | April 27, 2023 GMT | By JONEL ALECCIA

Posted on 04/28/2023 5:25:16 AM PDT by Red Badger

As a growing number of overweight Americans clamor for Ozempic and Wegovy — drugs touted by celebrities and on TikTok to pare pounds — an even more powerful obesity medicine is poised to upend treatment.

Tirzepatide, an Eli Lilly and Co. drug approved to treat type 2 diabetes under the brand name Mounjaro, helped people with the disease who were overweight or had obesity lose up to 16% of their body weight, or more than 34 pounds, over nearly 17 months, the company said on Thursday.

The late-stage study of the drug for weight loss adds to earlier evidence that similar participants without diabetes lost up to 22% of their body weight over that period with weekly injections of the drug. For a typical patient on the highest dose, that meant shedding more than 50 pounds.

Having diabetes makes it notoriously difficult to lose weight, said Dr. Nadia Ahmad, Lilly’s medical director of obesity clinical development, which means the recent results are especially significant. “We have not seen this degree of weight reduction,” she said

Based on the new results, which have not yet been published in full, company officials said they will finalize an application to the U.S. Food and Drug Administration for fast-track approval to sell tirzepatide for chronic weight management. A decision could come later this year. A company spokeswoman would not confirm whether the drug would be marketed for weight loss in the U.S. under a different brand name.

(Excerpt) Read more at 12ft.io ...


TOPICS: Business/Economy; Food; Health/Medicine; Society
KEYWORDS: eatless; obesity; weight
Navigation: use the links below to view more comments.
first previous 1-2021-4041-60 next last
To: Red Badger

Eat recklessly, take a pill, lose weight.

What could go wrong?

/s


21 posted on 04/28/2023 6:22:35 AM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
[ Post Reply | Private Reply | To 1 | View Replies]

To: George from New England

No but I’m seriously considering trying chickpea flour. A side tragedy in all this is I got a pasta machine near the end of last year and then this surprise diabetes ruined it.

It was a surprise because for at least 20 years I had been baffling doctors because my blood pressure, cholesterol and A1C were all perfect and I looked like I should be dead from clogged everything, I also ate like there was no tomorrow. Fry it and smother it in gravy and I’d eat it. I peaked last year at 454 lbs (I’m 6’6” so I looked heavy but not nearly as fat as I was) and I think my body decided it was done with my shenanigans and hit the brakes.

I still don’t see a difference in the mirror but I’m wearing clothes that haven’t fit for years. If I get concerned that I’m not making progress I try on pants I couldn’t button a couple years ago, I can’t even belt them tight enough to stay up now.


22 posted on 04/28/2023 6:23:01 AM PDT by Legatus (May the zot be with you)
[ Post Reply | Private Reply | To 14 | View Replies]

To: Red Badger
Also, the food sucked

That, my FRiend, is "the hospital 'diet'". Ironically, during my father's brief stay in both the hospital and the rehab facility, his T2 was reversed, lost 40lbs and blood sugar was on the LOW side. But of course, he reverted back to his original weight and bad habits once he'd healed.

23 posted on 04/28/2023 6:25:26 AM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
[ Post Reply | Private Reply | To 3 | View Replies]

To: Mom MD

Ok. Have to ask (mostly rhetorical):

Are you reserving these drugs for the morbidly obese, or are they being dispensed to the ‘merely’ obese?

As well, what is the maximum term of treatment, or is it open-ended?


24 posted on 04/28/2023 6:27:34 AM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
[ Post Reply | Private Reply | To 6 | View Replies]

To: logi_cal869

They served the ‘rubber chicken’ twice a day.

I stopped eating it after a couple of days.

I think they saved it and just kept putting it back on my tray every day............... 🤷‍♂️


25 posted on 04/28/2023 6:28:20 AM PDT by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
[ Post Reply | Private Reply | To 23 | View Replies]

To: Red Badger

Bottom line is, you can reverse metabolic disorder with diet and just a wee bit of exercise.

How I did it:

- OMAD - One meal a day. I eat one meal in the evening. No fast carbs. Any carbs in my meal come from vegetables low carb veggies.

- Effort to walk at least 10,000 steps. Easiest to fit these steps into your current lifestyle. Do things like park further from the store, take a couple extra laps in the store, take the stairs if you can, hunt mushrooms when not in season :).

Your body was taught to eat three times a day. It doesn’t need food that often if you feed it protein and slow carbs, like a caveman. I won’t kid you, it is hard to retrain your body to only get hungry around 4:00PM (for me), but it will adapt.

After one year, my A1C was 5.5 and my cholesterol was around 100. These numbers and my weight are steady after 5 years. My PCP was consulted and approved, but she still asks if I eat a low cholesterol diet. Guess she can’t help herself.


26 posted on 04/28/2023 6:31:10 AM PDT by IamConservative (I was nervous like the third chimp in line for the Ark after the rain started.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Legatus

Pasta is freakishly easy to make especially if you get a hand crank machine. I eat in about once every other week or so and it fits in well, especially if it’s the side dish. You need about 100 g of pasta flour (this is usually an Italian import) and one large egg. You can get three ish one cup servings out of that.


27 posted on 04/28/2023 6:31:49 AM PDT by PrincessB
[ Post Reply | Private Reply | To 12 | View Replies]

To: logi_cal869

I have a friend who is a nurse. She watches other nurses eat the donut and then up the insulin. If she suggests an apple she’s fat phobic.


28 posted on 04/28/2023 6:35:26 AM PDT by PrincessB
[ Post Reply | Private Reply | To 21 | View Replies]

To: Red Badger

Meth is probably a lot cheaper


29 posted on 04/28/2023 6:37:17 AM PDT by Bob434 (question )
[ Post Reply | Private Reply | To 1 | View Replies]

To: IamConservative

Everything you just said is in here.................

https://www.amazon.com/Undoctored-Health-Failed-Become-Smarter/dp/1623368669

30 posted on 04/28/2023 6:37:18 AM PDT by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
[ Post Reply | Private Reply | To 26 | View Replies]

To: Mom MD

I think it is working more because I already had changed much of my eating habits, and my body just needed help getting over the hill. I still have a lot more weight to lose.


31 posted on 04/28/2023 6:38:56 AM PDT by Ingtar
[ Post Reply | Private Reply | To 17 | View Replies]

To: UnwashedPeasant

I don’t trust big pharma and try to stay off as many medications as they want to throw at me. Too many side effects, so then you take something else to fix that issue. No thank you.


32 posted on 04/28/2023 6:41:32 AM PDT by FamiliarFace (I got my own way of livin' But everything gets done With a southern accent Where I come from. TP)
[ Post Reply | Private Reply | To 15 | View Replies]

To: Mom MD

“people who have not been able to lose before”

Had those people tried keto & fasting?

And what happens when the injections stop?


33 posted on 04/28/2023 6:46:00 AM PDT by Mr Rogers (We're a nation of feelings, not thoughts.)
[ Post Reply | Private Reply | To 6 | View Replies]

To: Legatus

“It seems for me that almost anything that comes in a box is dangerous”


I can think of no contrary examples to that assertion.

Could probably add “Anything that comes in a bag and doesn’t require refrigeration is dangerous”.


34 posted on 04/28/2023 6:58:10 AM PDT by DuncanWaring (The Lord uses the good ones; the bad ones use the Lord.)
[ Post Reply | Private Reply | To 12 | View Replies]

To: Mr Rogers

That’s a rhetorical question, right?


35 posted on 04/28/2023 6:58:52 AM PDT by DuncanWaring (The Lord uses the good ones; the bad ones use the Lord.)
[ Post Reply | Private Reply | To 33 | View Replies]

To: Red Badger
Gee, the big news is that we should allow (encourage) our children to become obese.

The drug companies announce a weight loss wonder drug on the same day.

Coincidence?

36 posted on 04/28/2023 7:10:46 AM PDT by Aevery_Freeman (Wow, they shut down FOX News pretty quickly!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: logi_cal869

right now the use for obesity is off label so there are no real guidelines how obese one is to use it. Treatment is open ended. It appears that if the med is stopped altogether weight cones back. It may be a smaller dose is necessary indefinitely to maintain the weight loss, which would make sense since we are treating metabolic syndrome. You cannot stop blood pressure medications once your blood pressure is normalized on medication. The disease is controlled not cured unfortunately


37 posted on 04/28/2023 7:29:28 AM PDT by Mom MD ( )
[ Post Reply | Private Reply | To 24 | View Replies]

To: Ingtar

Anything require me work in addition to the medication. you are doing a wonderful job and reaping the benefits. Keep up the good work


38 posted on 04/28/2023 7:31:18 AM PDT by Mom MD ( )
[ Post Reply | Private Reply | To 31 | View Replies]

To: logi_cal869

Not a pill an injection. And what you eat undoubtedly plays into the success. I don’t think anyone argues there are different metabolisms. There is finally good news for those who have struggled with weight their entire life


39 posted on 04/28/2023 7:35:40 AM PDT by Mom MD ( )
[ Post Reply | Private Reply | To 21 | View Replies]

To: Mr Rogers

Yes, I had tried keto and fasting. Both worked for about 40-60 pounds and then I would hit a plateau and no matter what I would eat or not eat, the weight would slowly return. But, I was not put on this for weight, but for blood sugar that was out of control. The meds and diet would not control it. Sadly, I still need to lose a bit more before I can start walking and working toward adding real exercise to the mix.


40 posted on 04/28/2023 7:40:30 AM PDT by Ingtar
[ Post Reply | Private Reply | To 33 | View Replies]


Navigation: use the links below to view more comments.
first previous 1-2021-4041-60 next last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson