Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study (Peer Reviewed)

PLOS ONE ^ | 02/16/2021 | 13 Authors

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Abstract

Background

Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV-2 infection. The study was aimed to explore the association between ivermectin prophylaxis and the development of SARS-CoV-2 infection among healthcare workers.

Methods

A hospital-based matched case-control study was conducted among healthcare workers of AIIMS Bhubaneswar, India, from September to October 2020. Profession, gender, age and date of diagnosis were matched for 186 case-control pairs. Cases and controls were healthcare workers who tested positive and negative, respectively, for COVID-19 by RT-PCR. Exposure was defined as the intake of ivermectin and/or hydroxychloroquine and/or vitamin-C and/or other prophylaxis for COVID-19. Data collection and entry was done in Epicollect5, and analysis was performed using STATA version 13. Conditional logistic regression models were used to describe the associated factors for SARS-CoV-2 infection.

Results

Ivermectin prophylaxis was taken by 76 controls and 41 cases. Two-dose ivermectin prophylaxis (AOR 0.27, 95% CI, 0.15–0.51) was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Those involved in physical activity (AOR 3.06 95% CI, 1.18–7.93) for more than an hour/day were more likely to contract SARS-CoV-2 infection. Type of household, COVID duty, single-dose ivermectin prophylaxis, vitamin-C prophylaxis and hydroxychloroquine prophylaxis were not associated with SARS-CoV-2 infection.

Conclusion

Two-dose ivermectin prophylaxis at a dose of 300 μg/kg with a gap of 72 hours was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Chemoprophylaxis has relevance in the containment of pandemic.

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About the Authors

Priyamadhaba Behera

Roles Conceptualization,

Formal analysis,

Investigation,

Methodology,

Project administration,

Resources,

Supervision,

Writing – original draft,

Writing – review & editing

Affiliation Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

Binod Kumar Patro

Roles Conceptualization,

Investigation,

Methodology,

Project administration,

Supervision,

Writing – review & editing

Affiliation Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

Arvind Kumar Singh

Roles Methodology,

Project administration,

Resources,

Supervision,

Writing – review & editing

Affiliation Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

Pradnya Dilip Chandanshive

Roles Data curation,

Formal analysis,

Writing – original draft

Affiliation Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

Ravikumar S. R.

Roles Data curation,

Formal analysis,

Methodology

Affiliation Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

https://orcid.org/0000-0003-0297-0177

Somen Kumar Pradhan

Roles Data curation,

Investigation,

Methodology,

Writing – review & editing

Affiliation Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

Siva Santosh Kumar Pentapati

Roles Data curation,

Methodology,

Writing – review & editing

Affiliation Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

Gitanjali Batmanabane

Roles Conceptualization,

Investigation,

Methodology,

Project administration,

Resources,

Supervision,

Writing – original draft,

Writing – review & editing

* E-mail: director@aiimsbhubaneswar.edu.in

Affiliation All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

https://orcid.org/0000-0001-7134-8395

Prasanta Raghab Mohapatra

Roles Conceptualization,

Writing – review & editing

Affiliation Department of Pulmonary Medicine and Critical Care, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

Biswa Mohan Padhy

Roles Conceptualization,

Writing – review & editing

Affiliation Department of Pharmacology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

Shakti Kumar Bal

Roles Conceptualization,

Writing – review & editing

Affiliation Department of Pulmonary Medicine and Critical Care, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

Sudipta Ranjan Singh

Roles Resources,

Writing – review & editing

Affiliation Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

Rashmi Ranjan Mohanty

Roles Conceptualization,

Writing – review & editing

Affiliation Department of General Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

Competing Interests

The authors have declared that no competing interests exist.

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[E. Pluribus Unum]

The Center for Democrat Control sez Ivermectin will kill ya and do not take it under any circumstances.

[SeekAndFind]

[Jane Long]

Bookmark.

[SeekAndFind]

RE: The Center for Democrat Control sez Ivermectin will kill ya and do not take it under any circumstances.

So, how come I don’t see many dead patients in India who have been administered this drug? Is there anything different between INDIAN physiology and American physiology? Are Indians different type of humans?

[SeekAndFind]

CHARACTERISTICS OF THE STUDY PARTICIPANTS

[SeekAndFind]

Conditional logistic regression models for associated factors of SARS-CoV-2 infection.

https://doi.org/10.1371/journal.pone.0247163.t004

[RushIsMyTeddyBear]

Bkmrk

[SeekAndFind]

A Doctor discusses the correct dosage of Ivermectin…

https://citizenfreepress.com/breaking/doctor-discusses-the-correct-dosage-of-ivermectin/

[SecAmndmt]

There are officially no effective treatments for cv19, because admitting there was an effective cv19 treatment, and putting it into widespread use would invalidate the EUA for the vaccines.

So...what is it about these cv19 vaccines that makes it more important to maintain the EUA, than save the lives of thousands of people (+ destroy the economy)?

[Doofer]

https://timesofindia.indiatimes.com/city/noida/ivermectin-to-be-used-for-covid-treatment-in-up-to-replace-hcq/articleshow/77423417.cms

[kiryandil]

$$$$$$$

[ThunderSleeps]

A 73% drop in infection is a disaster for the deep state fear mongers. It drops covid to well below seasonal flu in terms of sickness/death concerns. Virtually no-one would give a rip about covid if is significantly below seasonal flu in terms of overall health concern.

No wonder the deep state has (and continues to) work so hard to discredit and discount reports of successful treatment regimens. They provably show that covid is really a non factor. Yes, a non factor. There is no reasonable basis for locking down populations and destroying economies. It is all the plan of the left to accumulate more draconian powers.

[ptsal]

Format may need some work

[SeekAndFind]

RE: Format may need some work

Is it unreadable on your screen?

[saintgermaine]

Is there anything different between INDIAN physiology and American physiology?

The difference is politics and greed.

[dinodino]

Nope, and there are now 40 studies from all around the world, that basically all say the same thing about ivermectin: it works to prevent COVID-19, and to reduce the severity of illness in the sick.

[monkeyshine]

That doctor concludes that he will not be prescribing ivermectin because of the lack of prospective randomized double-blind placebo controlled studies.

We’ve wasted a year not studying various off the shelf treatments. Tens of millions are currently infected and there is even less data on how vaccines would work on those who are actively infected or who were infected (known and unknown) in the past.

This website has a lot of ‘anecdotal’ data, videos, research papers etc. The FLCCC (Front Line Critical Care Alliance (not sure why they don’t call it FLCCA))
https://covid19criticalcare.com/

[monkeyshine]

One reason is they (the NIH/CDC/FDA big pharma etc) wanted to advance the mRNA platform. It has been around a while but no drug or treatment or vaccine has ever been approved based on this technology. They are hopeful the platform can be used in the future for many different types of diseases and wanted to see it put into practice, basically making everyone a guinea pig for long term safety and efficacy and sacrificing those who needed treatment for the ‘greater good’ of advancing mRNA tech.

If it were widely known that you can just take $20 worth of cheap generics and clear the virus in 10 days, nobody would sign up for the vaccines and it would be hard to even maintain the protocols for the trials that were used to approve them. If everyone in the trials who got the virus knew they could take Ivermectin+ they would drop out of the trial and take the pills - thus ruining the trial. So they needed to put the kibosh on all potential treatments in order to advance the vaccine pipedream.

Of course, you could also add political motive and financial motive into the considerations. I don’t think any person could have really done that much better than Trump, but his biggest mistake was not pushing back harder against the Administrative State and spending the money to research treatments. Even today, 20 million unresolved cases of Covid-19 in the USA what good is a vaccine for those people?

[tennmountainman]

Our arrogant scientist and Doctors including Fauci think only our science
matters. What we have is junk science. Our arrogant scientist and doctors
destroyed our economy over their junk science.
All should be hung from a tall tree with barbed wire.