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Low-dose hydroxychloroquine therapy and mortality in hospitalised patients with COVID-19: a nationwide observational study of 8075 participants
Science Direct ^ | October 2020 | Belgian Collaborative Group on COVID-19 Hospital Surveillance

Posted on 10/04/2020 8:57:07 PM PDT by SeekAndFind

Highlights

Hydroxychloroquine (HCQ) 2400 mg over 5 days was used in Belgium for COVID-19.

Impact of HCQ on mortality among 8075 patients with COVID-19 was assessed.

Lower mortality in HCQ-treated patients as compared to supportive care.

Lower mortality was irrespective of symptom duration.

ABSTRACT

Hydroxychloroquine (HCQ) has been largely used and investigated as therapy for COVID-19 across various settings at a total dose usually ranging from 2400 mg to 9600 mg. In Belgium, off-label use of low-dose HCQ (total 2400 mg over 5 days) was recommended for hospitalised patients with COVID-19. We conducted a retrospective analysis of in-hospital mortality in the Belgian national COVID-19 hospital surveillance data. Patients treated either with HCQ monotherapy and supportive care (HCQ group) were compared with patients treated with supportive care only (no-HCQ group) using a competing risks proportional hazards regression with discharge alive as competing risk, adjusted for demographic and clinical features with robust standard errors. Of 8075 patients with complete discharge data on 24 May 2020 and diagnosed before 1 May 2020, 4542 received HCQ in monotherapy and 3533 were in the no-HCQ group. Death was reported in 804/4542 (17.7%) and 957/3533 (27.1%), respectively. In the multivariable analysis, mortality was lower in the HCQ group compared with the no-HCQ group [adjusted hazard ratio (aHR) = 0.684, 95% confidence interval (CI) 0.617–0.758]. Compared with the no-HCQ group, mortality in the HCQ group was reduced both in patients diagnosed ≤5 days (n = 3975) and >5 days (n = 3487) after symptom onset [aHR = 0.701 (95% CI 0.617–0.796) and aHR = 0.647 (95% CI 0.525–0.797), respectively].


(Excerpt) Read more at sciencedirect.com ...


TOPICS: Health/Medicine; Science; Society
KEYWORDS: covid19; hydroxychloroquine; study
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Compared with supportive care only, low-dose HCQ monotherapy was independently associated with lower mortality in hospitalised patients with COVID-19 diagnosed and treated early or later after symptom onset.

CLICK ABOVE ARTICLE LINK FOR THE DETAILS OF THE OBSERVATIONAL STUDY

1 posted on 10/04/2020 8:57:07 PM PDT by SeekAndFind
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To: Mrs. Don-o; tellw; Huskrrrr; Jane Long; Freedom'sWorthIt; Freedom56v2; BDParrish; Phx_RC

Ping as per your request...


2 posted on 10/04/2020 8:57:36 PM PDT by SeekAndFind
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To: SeekAndFind
As in a grand jury, this article cites many publications and detailed information demonstrating the proper and effective use of HCQ that has already saved millions of lives worldwide in this pandemic and could save millions more. A Belgium study of 8,075 hospitalized patients found a 65% reduction. Likewise, a recent study from Saudi Arabia found 43% fewer hospitalizations and 45% fewer ICU admissions. For high-risk nursing home patients in Spain HCQ cut the risk of a bad outcome in half.

A large Henry Ford Hospital System study found a mortality rate for 2,541 patients of 13.5% for HCQ alone, 20.1% for HCQ plus azithromycin, and 26.4% for neither.

A new analysis by R. Clinton Ohlers is title, "Effectiveness of hydroxychloroquine was hiding in plain sight." An early widely publicized study concluded that HCQ was not effective in New York patients. In truth: "Survival rates for hospitalized patients who received the drug approached 85%" and "with azithromycin the survival rate rose as high as 90%." Without either drug, "survival fell to levels as low as 53%." Conclusion: "a highly effective, inexpensive, and widely available treatment for COVID-19 is already in hand."

Similarly, Dr. Watanabe from Brazil reanalyzed a Minnesota study that had a negative conclusion. For very early HCQ use, he found that "reduction in symptomatic outcomes is 72% after 0 days (first day of infection), 48.9% after 1 day and 29.3% after 2 days" – all compared to a placebo group. Conclusion: "Infected patients may have a large benefit if treated as early as possible."

Clearly, many media-hyped studies saying HCQ has no benefits are not credible. Some medical journal papers were retracted.

An article by physician Norman Doidge is "Hydroxychloroquine: A Morality Tale – A startling investigation into how a cheap, well-known drug became a political football in the midst of a pandemic." Conclusion: "Worldwide [HCQ] might save a million or more people before COVID is tamed." Some studies were poorly designed. In one case "the patients were given the medication late – on average 16.6 days after the first symptoms."

Another important study is: "Early treatment with hydroxychloroquine: a country-based analysis." Critical conclusion: The death rate from the virus in a number of nations where HCQ has been made widely available (the treatment group) is about 74% less than in those nations, including the U.S., where it has not been made available (the control group).

Many physicians and experts on viruses have published strong pro-HCQ articles, notably Dr. Harvey Risch from Yale University. He has repeatedly argued for using HCQ as the standard outpatient therapy. This article is for a general audience. In a medical journal article, he warned against "sitting by and letting hundreds of thousands die because we did not have the courage to act according to our rational calculations."

Experienced pro-HCQ front-line doctors have appeared on Fox News shows, including Dr. Stephen Smith, Dr, Marc Siegel (whose 96-year-old father was saved with HCQ), Dr. Janette Nesheiwat, Dr. Mehmet Oz and Dr. Risch who noted, "We're basically fighting a propaganda war against the medical facts" and that "75,000 to 100,000 lives will be saved" if the national HCQ stockpile were used. Fox's Sean Hannity had Dr. George Fareed, an early user of HCQ, on a recent radio show.

A new CDC publication reveals prescriptions for HCQ at retail stores (not mail order). In March through June this year there likely were 680,000 prescriptions for treating the virus. After the government clamp down, prescriptions in May and June averaged 80,000 a month. This limited use may help explain many reduced death rates.

And despite negative actions by some governments and the World Health Organization, the Sermo survey of physicians in 30 countries found for this September that HCQ is being used for 22% of patients outside hospitals, 21% inside them and even 14% in ICUs.

4. Problems with Fauci's Positions

Dr. Fauci is only satisfied with randomized control trials (RCTs). This position has been sharply debunked, as has the assertion of negative health effects and that HCQ risks outweigh its benefits.

Thomas R. Frieden, former head of the CDC, concluded in 2017: "Despite their strengths, RCTs have substantial limitations." He supported using many other kinds of data that now constitute the evidence for using HCQ.

Similarly, Norman Doidge observed: "RCT is best understood as standing not for Randomized Control Trials, but rather 'Rigidly Constrained Thinking.' in the current COVID-19 situation … we cannot simply, as so many are insisting [namely Fauci], rely only on the long-awaited RCTs to decide how to treat COVID-19."

Importantly, hundreds of drugs have been approved without RCTs, including hydrocortisone, Lasix, tetanus vaccine, insulin, tetracycline, warfarin, heparin, prednisone, half of chemotherapy drugs used in cancer and uses of HCQ for many diseases, such as malaria and lupus.

Another false criticism has recently been debunked: "HCQ decreases cardiac events. HCQ should not be restricted in COVID-19 patients out of fear of cardiac mortality." Another study concluded: "HCQ administration is safe for a short-term treatment for patients with COVID-19 … causing … no directly attributable arrhythmic deaths." Dr. James Todaro concluded: "It is highly unlikely that fatal cardiac cases are from hydroxychloroquine use. It is far more likely that the disease itself is the cause of arrhythmias and cardiac injury during the hyperinflammation phase of severe cases of COVID-19."

An article by Steven Hatfill, "Why Is The Media Suppressing Information About Hydroxychloroquine's Effectiveness Against COVID?" noted, "There are now 53 studies that show positive results of hydroxychloroquine in COVID-19 infections." It also highlights the early Fauci and FDA strategy that promoted use of HCQ for hospitalized patients (when it was mostly too late) rather than early outpatient use.

The Doidge article noted that for a major study that found a 66% reduction in hospital deaths from use of HCQ, Fauci "didn't seem excited." The key question: "Why should anyone facing a pandemic wish to discredit potentially lifesaving medications?" The answer: The billions of dollars to be made from selling medications and vaccines. Fauci has had a very close relationship with pharmaceutical companies and has patents for one of the leading vaccines being tested by Moderna.

In August three-front line physicians wrote a detailed open letter to Fauci making the medical case for unblocking widespread use of HCQ. "You are largely unchallenged in terms of your medical opinions. You are the de facto COVID-19 Czar. … Americans must not continue to die unnecessarily. Adults must resume employment and our youth return to school. Locking down America while awaiting an imperfect vaccine has done far more damage to Americans than the coronavirus."

An important article by an epidemiologist rebutted the explanation by Fauci of why he rejects the incredible amount of evidence supporting use of HCQ. Conclusion: "I earnestly hope that Dr. Fauci reconsiders his opposition to HCQ and restores his hitherto considerable reputation."

3 posted on 10/04/2020 9:02:47 PM PDT by SeekAndFind
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To: SeekAndFind

I’m sure this will be on front pages across America tomorrow.


4 posted on 10/04/2020 9:05:16 PM PDT by dp0622 (Tried a coup, a fake tax story, tramp slander, Russia nonsense, impeachment and a virus. They lost.)
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To: dp0622

RE: I’m sure this will be on front pages across America tomorrow.

In a better, saner world, yes. But we don’t live in such a world now.


5 posted on 10/04/2020 9:10:10 PM PDT by SeekAndFind
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To: SeekAndFind

No we don’t.

What I wouldn’t give for one MAJOR network to be conservative.

Or fair even.


6 posted on 10/04/2020 9:11:03 PM PDT by dp0622 (Tried a coup, a fake tax story, tramp slander, Russia nonsense, impeachment and a virus. They lost.)
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To: SeekAndFind

Thank you.

Bookmark.


7 posted on 10/04/2020 9:12:38 PM PDT by Uncle Miltie (Rioters for Biden!)
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To: SeekAndFind

Thank you for sharing this important news.

Bye Dr. Fauci


8 posted on 10/04/2020 9:22:24 PM PDT by Irish Eyes
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To: SeekAndFind

Can I know how many MGs of HCQ, Zinc and azithromycin are recommended without reading all the links? I have heard that you take it for five days.


9 posted on 10/04/2020 9:33:04 PM PDT by \/\/ayne (I regret that I have but one subscription cancellation notice to give to my local newspaper)
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To: \/\/ayne

This is the Dr. Zelenko treatment protocol for COVID-19:

https://faculty.utrgv.edu/eleftherios.gkioulekas/zelenko/Zelenko-memo-August-protocol.pdf


10 posted on 10/04/2020 9:46:09 PM PDT by SeekAndFind
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To: \/\/ayne

This is the Dr. Zelenko prophylaxis protocol for COVID-19:

https://faculty.utrgv.edu/eleftherios.gkioulekas/zelenko/Zelenko-memo-August-prophylaxis.pdf


11 posted on 10/04/2020 9:49:10 PM PDT by SeekAndFind
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To: SeekAndFind

Thanks and I did read through some studies after all.


12 posted on 10/04/2020 10:16:13 PM PDT by \/\/ayne (I regret that I have but one subscription cancellation notice to give to my local newspaper)
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To: dp0622

LOL!


13 posted on 10/04/2020 10:44:45 PM PDT by jjmucr (Amazon Prime)
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To: SeekAndFind
Dr. Zelenko updated his protocols. Thanks for posting the info.
14 posted on 10/04/2020 11:06:17 PM PDT by Widget Jr
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To: SeekAndFind
This makes no mention of Zinc sulfate which is key in using HCQ. The death rate would be far lower. The proper Zelenko protocol is HCQ, Zinc and Zpak. It really ticks me off that so many refuse to study this.
15 posted on 10/04/2020 11:54:12 PM PDT by WWG1WWA ( Unity, not division)
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To: SeekAndFind

My entire family had Covid six weeks ago and wifey earlier

My two oldest boys were sickest....like three to four day cold or very mild flu

They tested positive

I got sick too same time as did youngest but didn’t get tested

I was very very short of breath like couldn’t lie in bath tub without feeling like choking and my phlegm was like boiled custard heavy and consistent and a little fever one night

We all too plaquenil 800 first day and 400 per day for 5-10 days after plus z pak and liquid true zinc in water ....very very nasty the zinc is...whew

Anyhow ....it was not much honestly

And I’ve a horrible multiple efforts rebuilt heart and a pacemaker and morbid sleep apnea at six five 235

And serious pulmonary scar tissue from two sternum crack opens 15 years ago

My wife who had no medicine was much sicker

My youngest was fairly asymptomatic except loss of taste

My oldest daughters fiancée was quite ill like flu but refused my help .....shoulda listened....hydroxchloroquine helps I’m convinced

Oldest daughter was asymptomatic

We got it from a private jet pilot for a big firm here who caught it in Los Angeles ,....


16 posted on 10/05/2020 12:06:47 AM PDT by wardaddy (I applaud Jim Robinson for his comments on the Southern Monuments decision ...thank you run the tra)
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To: SeekAndFind

Thanks for this post and for this protocol info.


17 posted on 10/05/2020 2:43:58 AM PDT by Freedom'sWorthIt
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To: SeekAndFind

TDS kills!

Your estimate on how many died who could have been saved if HCQ++ had been accepted?

Instead, it was poo-poohed by the Dems and the media just because Trump recommended it.

TDS kills!


18 posted on 10/05/2020 3:02:31 AM PDT by FroggyTheGremlim (I'll be good, I will, I will!)
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To: SeekAndFind
Death was reported in 804/4542 (17.7%) [of the group treated with HCQ] and 957/3533 (27.1%) [of those not treated].

That's a 37 percent reduction in fatalities. Keep in mind, that these were hospitalized patients. HQC is most effective when taken BEFORE hospitalization, and also with zinc and an antibiotic.

19 posted on 10/05/2020 3:36:25 AM PDT by norwaypinesavage (Calm down and enjoy the ride, great things are happening for our country)
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To: norwaypinesavage

Average for those receiving HCQ was 66 versus 77 for those not receiving HCQ. I imagine they try to correct for this statistically somehow but the raw death percentages for HCQ vs non HCQ are meaningless.


20 posted on 10/05/2020 4:55:56 AM PDT by brookwood (Obama said you could keep your plan - Sanders says higher taxes will improve the weather)
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