Posted on 09/06/2020 9:12:12 PM PDT by ConservativeMind
Nicotinamide riboside (NR) is pretty amazing. It has already been shown in several studies to be effective in boosting metabolism....
As mice, like all mammals, age, the regenerative capacity of certain organs (such as the liver and kidneys) and muscles (including the heart) diminishes. Their ability to repair them following an injury is also affected. This leads to many of the disorders typical of aging.
Under normal conditions, these stem cells, reacting to signals sent by the body, regenerate damaged organs by producing new specific cells. At least in young bodies.
This is why the researchers wanted to "revitalize" stem cells in the muscles of elderly mice. And they did so by precisely targeting the molecules that help the mitochondria to function properly. "We gave nicotinamide riboside to 2-year-old mice, which is an advanced age for them," said the researcher. "This substance, which is close to vitamin B3, is a precursor of NAD+, a molecule that plays a key role in mitochondrial activity. And our results are extremely promising: muscular regeneration is much better in mice that received NR, and they lived longer than the mice that didn't get it."
A breakthrough for regenerative medicine
Parallel studies have revealed a comparable effect on stem cells of the brain and skin. "This work could have very important implications in the field of regenerative medicine," said Auwerx. "We are not talking about introducing foreign substances into the body but rather restoring the body's ability to repair itself with a product that can be taken with food." This work on the aging process also has potential for treating diseases that can affect - and be fatal - in young people, like muscular dystrophy (myopathy).
So far, no negative side effects have been observed following the use of NR, even at high doses.
(Excerpt) Read more at medicalxpress.com ...
My body could used all the help it can get after years of abuse bump.
;-)
BOOKbump
Hmmm... If I can get some, maybe I will make it to my target of 107... Hang the cost, I’ll take the 20 years...
When I was riding a couple hundred miles a week on my bicycle... I took two supplements, Alpha Lipoic Acid and Acetyl-L-Carnitine, they supposedly helped increase the rate that fat could be metabolized on long rides when the carbohydrate stores in my muscles became depleted. They were also intended to reduce oxydative stress on muscles used in strenuous exercise. They seemed to improve my comfort level and the recorded times on my 40 and 60 mile training rides. It was significant enough that it seemed to be more than just a placebo effect.
Unfortunately, they also seemed to cause me to have stinkier gas and body odor that my wife objected to... so I had to quit using them. But they are the only supplements that I have ever taken that really seemed to have any meaurable effect.
Ten or so years later my dad was perscribed the two supplements because they were shown to reduce the damage caused to the heart muscle after someone had a heart attack.
I do take a multivitamin to try and help make up for a diet that is not as diverse as it probably should be. But I do not really believe the claims made about most supplements sold that make so many “promises” that are not really backed up by studies on their effects on humans.
Just take niacinamide if cost is a problem. Both are forms of B3.
LOL
There are cheaper alternatives. I don’t want to make any recommendations though but search at Amazon.
Kahn endorses Nicotinamide riboside.
*PING* to L J.
Thanks to ConservativeMind.
This story is dated April 2016. Is there updated information?
bump for reference
I learned about this several years ago, and did some serious research on it, as the price gave me heartburn. I am still taking it, going on three years, and I have to say it’s one of the few supplements I take, and it’s subtle, buy my high blood pressure lowered itself, and I’m no longer on meds. My cholesterol is now half of what it had been, without any diet changes. Also, I take another supplement, which is a chemically altered form of CoQ10, called Ubiquinol, which has served me well. It has been said at high doses of Ubiquinol, the effects of arteriosclerosis can be somewhat reversed. Between the Ubiquinol, and atorvastatin, my doc tells me he believes my heart is now doing much better than it had been (CHF).
Save
Bttt
bkmk
“Will it work on my 42-year old piano?” I don’t know, man. But I tried using it on my trumpet and it really blew.
But did you get muted results?
I start screaming at my radio every time I hear ads for nutritional supplements (one of which is advertised heavily on talk radio).
ping
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