Posted on 08/18/2020 8:04:28 AM PDT by SeekAndFind
Researchers at Case Western Reserve University have added to the growing body of understanding about how hydroxychloroquine (HCQ) is not a possible defense against COVID-19.
Specifically, they found that HCQ is not effective in preventing COVID-19 in patients with lupus and rheumatoid arthritis (RA), suggesting a broader interpretation of HCQ as ineffective preventive medicine for the general population. Their findings were recently published in the Annals of the Rheumatic Diseases.
Many researchers have focused on patients with systemic lupus erythematosus (SLE) and RA because HCQ is frequently taken by these patients. Anecdotal reports in the early stages of the pandemic showed these patients were not getting COVID-19. Earlier researchers then explored HCQ in the lab and found it effective against the virus, in addition to its already established anti-inflammatory properties, so testing in people for prevention or treatment at first held some promise. Since those early tests, various more recent studies have shown that HCQ is not effective in treating moderate-to-severe hospitalized cases. Treatment with HCQ early in the disease or for mild cases is still under review.
"Our study shows, with a large degree of confidence, that HCQ is ineffective as a preventive antiviral in people with SLE and/or RA taking drugs that suppress their immune system, putting them at greater risk," said Mendel Singer, Ph.D., MPH, lead author and associate professor and vice chair for education in the Department of Population & Quantitative Health Sciences at the Case Western Reserve School of Medicine. "Given how the study was structured, one can make an educated extension that it is not effective in preventing COVID-19 in people without those conditions. It is not uncommon for something to show promise in the lab, and then prove ineffective in the more complex biological landscape of humans."
The Case Western Reserve team drew on a large national database, pulling de-identified patient data from 36 health systems, to compile a much larger study than previous work, looking at patients with SLE and/or RA and their health outcomes related to their use of HCQ. Prior studies had fewer than 20 COVID-19 patients with SLE and/or RA; this study had 159. This study showed that patients with SLE and/or RA who contracted COVID-19 were just as likely to be taking HCQ as SLE and/or RA patients who did not get COVID-19.
"By drawing on data from a relatively large patient population with lupus and/or RA, we can offer a higher level of confidence in our findings," said Singer. "We see from this large retrospective review that this drug is ineffective in preventing COVID-19 in these patients who have been taking HCQ. If HCQ were effective in prevention, we would have seen fewer HCQ-taking SLE/RA patients with COVID-19, but did not. This likely means that HCQ is not active against the SARS-CoV-2 virus in humans—versus in the lab—and is unlikely to be an effective preventive antiviral for anyone."
Does Hydroxychloroquine alone, perform as a knockout drug --- attacking the virus in a manner much like, if not exactly the same as, treating a digestive tract parasitic infection with one of the quinine cousins --- about which a medical practioner's guideline can firmly be established?
Answer:
Of course, we have found that Hydroxychloroquine alone, does NOT perform as a knockout drug directly vs the SARS-2-CoV Coronavirus itself.
But we already knew that beforehand. Medical research has known the Hydroxychloroquine affects mechanisms at and within human cells --- those being the battlefields where Hydroxychloroquine indirectly fights the replication purpose of the virus.
There is a distinction between TWO different attack vectors, and those are being confused by what studies "say" and seem to pursue (as reported by the leftist "news" media and Dr. Fauci):
HCQ directly vs a parasite, is the typical support for a guideline that doctors can practice.
HCQ indirectly vs a virus, is a grey area, but apparently worthwhile, and doctors find encouraging enough to engage HCQ.
Our interest in Hydroxychloroquine plus Zinc is NOT as a directly offensive weapon against the virus, but as something that indirectly fights the virus at, and within, the human cell as a battlefield, thereby blunting SARS-2-CoV replication.
July 27, 2020, Mobeen Syed, MD, had an early presentation within the first video of the combined efforts by America's Frontline Doctors and Tea Party Patriots Foundation.
Dr. Mobeen Syed's explanation of the mechanisms (plural) of HCQ, re its use-full-ness in the battle against the SARS-2-CoV Coronavirus, by frustrating the attempt by the coronavirus, to use some of a human cell's features for replicating the coronavirus.
I had to watch his "DrBeen" (he is known as, online) explanation of HCQ mechanisms several times, in order to gather his quick English dialect re some of the terminology that he used (egs. mRNA is "messenger RNA").
https://www.freerepublic.com/focus/f-news/3875427/posts
Q: How can they always forget to include zinc with their studies?
A: Because they aren’t wanting to let anyone know that there is a cheap, effective way to fight CoVid19.
“And they always leave out the zinc. The zinc is the virus killer; the quinine is just the vehicle to get it through the cell walls”
The very basis of HCQ working to defeat the Wu Flu is that it opens the cell to zinc; zinc severely inhibits the reproduction of the virus and, if you catch it early enough after symptoms start, you kill it off. If you don’t catch it early enough, then it isn’t the disease that kills you, it is the cytokine storm that the body develops in order to kill it off that kills you - your immune system goes haywire.
HCQ let’s zinc into the cells because it is a zinc ionophore. Well, it isn’t the only one out there and available to the general public - there is also Quercetin. It is less efficient than HCQ on a mg-for-mg basis, but if you take about 1,000 mg of quercetin/day with zinc, it’ll do about the same job. No HCQ or permission of the drug Nazis necessary. Look it up - the internet is full of some very fine information if you make the effort.
You are exactly right: “And they always leave out the zinc. The zinc is the virus killer; the quinine is just the vehicle to get it through the cell walls.”
Fake News.
Fake Science.
If they leave out zinc, they have no credibility.
https://www.lifematters.life/notes
It works by helping the body absorb zinc.
Everyone should be taking 150 mg of zinc a day.
COVID-19 is SARS 1
Quinine works fine though; I’ve been taking it daily in its tonic water application, mixed with a small amount of gin...
I like your idea of making HCQ an over the counter medication, but not azithromycin. If people misuse any antibiotics, they are likely to create a bigger problem.
There are a lot of people who think that if they get a cold, the doctor should just give them an antibiotic. Antibiotics don’t work on viruses, but the commoner doesn’t seem to understand this. Maybe they will now, though.
At any rate, if you use antibiotics more frequently, you will likely end up with resistant bacteria at some point. That’s a harder problem to take care of.
Better to keep antibiotics by prescription.
I have a friend who is on immune surpessants due to other problems.
Lives in a state where HClQ is banned. And in the county with the highest number of Covid cases in a four state area.. Is a volunteer Firefighter / EMS so is exposed to people dying of Covid.
He drinks a quart of tonic water and takes 100mg zinc Piccolinate daily. Hasn’t gotten sick yet.
Sounds like another study ignoring the issue.
Namely, the HCQ cocktail has been effective in treating people as soon as they have been tested positive for covid.
If the medical bureaucrats really wanted to find out if HCQ was effective they would survey all the people who have taken HCQ with these questions:
What date did you have symptoms?
What date did you know you tested positive?
What date were you given HCQ?
How old are you?
What comorbidities do you have?
What was your outcome?
Another study designed to fail. Such studies have been going on for decades. The FDA is the most corrupt agency in the government. I'd love to know who funded the study.
So you have people with SLE and RA taking drugs that suppress their immune systems giving HCQ or any additional drug a huge hill to climb and somehow that translates to being ineffective in someone whose immune system is not suppressed? More TDS reasoning right there.
Malaria is not a virus or a bacterium.
It is a parasitic eukaryote (cell with a nucleus.)
This nation in general is completely illiterate when it comes to science. Making assertions without checking facts first is unhelpful, to say the least.
The people who were part of this “study” were already immune-compromised. I’m not really sure what the point of this was, other than to confirm that those with pre-existing conditions are susceptible to the disease. Also notice no mention of zinc.
Scientists are so corrupt that it is hard to know what to believe.
Sorry, but Malaria is not caused by a virus, but by a protozoan, a bacterial parasite. There’s literally a huge difference.
However, a 2005 peer-reviewed paper published by Fauci’s own organization showed that peer-reviewed double-blind research showed that HCL was an effective anti-viral agent as both a prophylactic and a treatment for infected individuals who had Corona virus diseases. COVID19 is a Corona Virus Disease.
Hydroxychloroquine with zinc is indeed used to prevent COVID infection.
Dr. Vladimir Zelenko is statistically at high risk for infection. Dr. Zelenko uses HCQ+Zinc for himself and is confident enough in its preventive ability that he sees COVID patients without wearing a mask.
correct
they want to get the idea out there it isnt preventative at all by saying its not preventative for those with lupus and ra
that is exactly what they are trying to say without saying it, because they would be shot down immediately because they have zero evidence to make such a much bigger claim off a study of only pre-existing condition populations
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