Posted on 05/12/2020 5:35:05 PM PDT by RaceBannon
new thread
Corona Virus Daily Thread #52 COVID-19 5/12/2020
Well, I have an explanation as to why the GA health department numbers are so different than what I have been logging each day. I know the AJC is a liberal rag, but this article confirms what I was seeing:
New changes to state’s virus data confuse experts, residents alike
...
“ Death counts and other essential figures DPH publishes on COVID-19 have ticked up and down as the state changes the way that it reports them. While the state has added to the metrics it publishes, it has stopped running others and shifted its method of counting cases.”
...
An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31103-X/fulltext
15 states now investigating child illness possibly linked to coronavirus, Cuomo says
BY AUDREY MCNAMARA
MAY 13, 2020 / 3:20 PM / CBS NEWS
“New York is in many ways the tip of the arrow here,” Cuomo said. “(We are) looking at 102 cases where children who may have been infected with the COVID virus show symptoms of an inflammatory disease like Kawasaki Disease, or toxic shock-like syndrome.”
According to the governor (Cuomo), 14 other states, as well as Washington D.C. and five European countries, have reported cases. The states are: California, Connecticut, Delaware, Georgia, Illinois, Kentucky, Louisiana, Massachusetts, Mississippi, New Jersey, Ohio, Pennsylvania, Utah and Washington...
https://www.cbsnews.com/news/kawasaki-disease-15-states-child-illness-coronavirus-cuomo/
AgStuckinLBKIn reply to Aggie95 • 10:31aAG
Imagine your blood vessel as a pipe. And along this pipe you have boxes lining the inside of the pipe (endothelial cells) with fail safe mechanisms that release material (vWF, clotting factors) to clog up the pipe if it gets damage to prevent from losing all the liquid in the pipe (preventing bleeding out). Normally these fail safes only activate when the pipe is damaged (like a cut or laceration) and having a big leak (bleeding).
Now imagine some rats (the rona) got loose in your pipes, and made holes in your pipe (leaky endothelial cells) and starting chewing on the wires that connected the control box for the failsafes (pericytes) to the actual failsafes (endothelial cells) causing the failsafes to activate prematurely. This causes the pipe to clog when it doesn’t need to. Physiologically, this leads to downstream clotting events from the pipes which manifest as strokes, pulmonary embolisms etc...
Diabetics have leakier, more brittle pipes for the rats to chew through this making them more susceptible.
Coronary artery disease patients usually have disease not just in their coronary arteries (arteries that supply blood to heart) but in all of their arteries which is equivalent to gunk buildup in pipes over the years.
Lovenox and heparin are anticlotting agents that help combat all of the new clotting factors that are being released.
Hope this helps. .
have no idea if this has any bearing now or in the future with possible symptoms and the Blood Brain Barrier that has pericytes
The pericyte: a forgotten cell type with important implications for Alzheimer’s disease?
https://www.ncbi.nlm.nih.gov/pubmed/24946075
While over there, take a look at Mexico. Ugh.
do pericytles have anything to do with loss of smell or taste?
Pericytes: Problems and Promises for CNS Repair
https://www.frontiersin.org/articles/10.3389/fncel.2019.00546/full
Didn’t know you were born here.
It’s usually us transplants who love it the most, but I know how you feel.
Those huge restaurants around Lincoln Center are going to suffer if the opera, ballet, concert, theatre attendance falls off.
perhaps
https://onlinelibrary.wiley.com/doi/pdf/10.1002/alr.22593
. Conversely, the target of the virus may not be the neurons but other nonneuronal cells that express ACE2 receptors such as the olfactory epithelium sustentacular
cells, microvillar cells, Bowman’s gland cells, horizontal basal cells and olfactory bulb
pericytes23. Brann et al.23, speculated that the loss of smell reported by COVID-19 patients is
due to the infection of the supporting cells and vascular pericytes of the olfactory epithelium
and bulb which, consequently, alters the function of the olfactory neurons
Yeah. They didn’t want it to look like Trump was right.
Is COVID-19 an Endothelial Disease?
https://www.mdpi.com/2077-0383/9/5/1417/pdf
All of the drugs proposed as a potential therapeutic strategy to treat COVID-19 patients have been shown to improve endothelial function, including tocilizumab, colchicine, chloroquine/hydroxychloroquine, azithromycin, and famotidine......
.....Even the antimalaric agents chloroquine and hydroxychloroquine, initially proposed as a therapy for COVID-19 based on anecdotal data [229,236], have been shown to improve endothelial function [237,238]. If our theory is correct [239], other drugs that might be effective in treating COVID-19 patients through their beneficial effects on endothelial cells include alpha 1 adrenergic receptor blockers (e.g., doxazosin) [240], modulators of Sigma receptors [241–243], metformin [244], indomethacin [245], and endothelin receptor antagonists (e.g., bosentan) [246]. However, data from randomized trials confirming the actual efficacy of these drugs are not (yet) available.
12 Urgent Actions to Reopen America and Prevent an Economic Depression (5/13/20)
Sioux City North KOA reopens (South Dakota, 5/13/20)
WATCH NOW: Gov. Kim Reynolds speaks at COVID-19 press conference (Iowa, 5/13/20)
New daily high: 4 deaths in Woodbury County from COVID-19 (Iowa, Nebraska, South Dakota, 5/12/20)
WATCH NOW: Shoppers express happiness on reopening day at Southern Hills Mall (Iowa, 5/13/20)
Allegheny County has 12 new COVID-19 deaths; state gets supply of drug (Pennsylvania, 5/13/20)
USD pairing students, businesses affected by COVID-19 (5/12/20)
The endothelium is directly involved in peripheral vascular disease, stroke, heart disease, diabetes, insulin resistance, chronic kidney failure, tumor growth, metastasis, venous thrombosis, and severe viral infectious diseases. Dysfunction of the vascular endothelium is thus a hallmark of human diseases.
What are the comorbities of Covid-19?
Heartburn Drug Decreased COVID-19 Disease Fatalities
I posted something very early on from a guy who said stock up on Pepcid, Benadryl, and a PPI for Covid 19. He posted it back in January
“But here’s the interesting part: they found that simultaneous treatment with omeprazole (at human therapeutic concentrations) increased the activity of apronitin by 2.7 fold and increased the activity of remdesivir by 10-fold. That seems like a very useful observation! As far as I can see, the paper did not check for an interaction of omeprazole and camostat/nafamostat, which would be interesting to know as well. The same group had noted in 2019 that the drug increased the activity of acyclovir against the herpes virus.
COVID-19 Drugs: Study Shows Common And Cheap Heartburn Drug Famotidine Improves Outcomes Of Hospitalized COVID-19 Patients
Source: COVID-19 Drugs May 11, 2020 3 days ago
COVID-19 Drugs: A research study by Columbia University, Northwell Health and Massachusetts General Hospital shows that Famotidine, a common heartburn drug improved the clinical outcomes of hospitalized COVID-19 patients.
The study involving 1620 patients from more than 10 hospitals in the United States showed that Famotidine associated with reduced risk of intubation or death in hospitalized COVID-19 patients. However further randomized controlled trials are warranted and also detailed studies are needed to understand the mode of its efficacy. https://www.medrxiv.org/content/10.1101/2020.05.01.20086694v1.full.pdf+html
The drug was chosen as earlier drug repurposing computer modeling studies showed that the drug molecular structure had very good potential to block ‘docking sites’ on the spike protein structures of the SARS-CoV-2 coronavirus, rendering the virus to become inactive and not capable of entering host cells and replicating.
“Cargill shuts down Quebec plant after 64 workers test positive for COVID-19”
The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission
View ORCID ProfileValentyn Stadnytskyi, View ORCID ProfileChristina E. Bax, View ORCID ProfileAdriaan Bax, and Philip Anfinrud
PNAS first published May 13, 2020 https://doi.org/10.1073/pnas.2006874117
Summary: One minute of talking loudly can produce more than 1,000 droplets that float in the air for over eight minutes.
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