Posted on 03/28/2020 11:13:33 AM PDT by Mariner
Thread #29 here:
http://freerepublic.com/focus/chat/3828913/posts?page=1
I think we’re reading too much into his brief summary of the brief email.
Hope so, anyway.
I haven’t heard Adler blaming POTUS for the Austin cases, yet, like the NOLA mayor has.
Adler waited until last minute, to cancel SXSW, but...he did.
It was after Mardi Gras, but....the NOLA gal’s blame game is getting old.
Gottlieb is one of the smart ones. :-)
I was using “family to feed” to cover all the expenses of a wage earner who has a wife and children. If the boss isn’t paying them while they are out, it’s a big, big problem. People are closer to the edge these days.
Thank God for Gottlieb! (That could be a pun depending on the meaning of his name ;)
But for this to succeed, EVERYONE needs to wear a surgical mask.
Anyone NOT wearing a mask should be shunned and avoided.
This needs to be the new meme.
He said that he's happy to report on transmission of COVID....it spreads by touching your face.....so, just wash your hands and don't touch your face.
I wish he'd of explained this to the Wuhan and Italian docs...we're lucky he's discovered this, and is sharing with US.
Here's a link to the segment...
@monicalsims Please, click and watch. I don't con. If you got the coronavirus and were damaged from it, it would be very bad thing. You are a carrier . . not of this disease but of fun, happiness, and big smiles. Stay safe. You do matter.https://t.co/XbOFNsQ9N7— Richard Erickson (@rgus63) March 29, 2020
You are right. I will give credit where credit is due. I am no fan of Adler, but he did get with the program, albeit at the eleventh hour. Prior to that he was acting pretty nonchalant about it, telling people to go to bars and restaurants and not worry. That was jaw dropping. Now he’s gone the other way and has shut down construction.
N95 are simply better at protecting us from any sort of airborne disease than homemade masks, which at best are only equivalent to surgical masks which only protect other people from the wearer.
Furthermore healthcare workers need better protection than N95 masks against the Wuhan Virus. The things are too uncomfortable to wear long, unuseable when doing heavy labor like turning patients over, and simply don't provide enough protection against the Wuhan Virus. They're just better than nothing. What healthcare workers need are N98 and N99 masks with better air flow and filters.
take it with a grain of salt. Ventilators are being pumped out, and 3M and the pillow guy is churning out masks. I forget who’s doing PPEs, but that’s on like donkey kong too just like the distilleries producing swimming pools of hand sanitizer for hospitals, and motorcycle helmet guys and 3-d printer open source patterns for producing face shields. Supplies will go to hotspots first and rotated to the next.
We’ve got this. It’s not going to be easy, but we’ve got this.
LOL!!
WV cop teleprompter ;-)
“A recent letter to The Lancet has noted that comorbidities reported so far for severe coronavirus patients include hypertension and either type I or type II diabetes. These patients are often being treated with ACE-1 inhibitors or angiotensin-receptor antagonists. The tricky part is that both diabetes itself and treatment with either of those drug classes increases the expression of ACE-2 protein. At first thought, that would probably not be a good thing, loading up the cells with more viral target proteins. But wait: there’s another effect, as noted in this new paper. It builds on reports from China to suggest that a mechanism of lung injury during the viral infection may be through inappropriate effects of excess free angiotensin-II protein, which is floating around out there because the ACE-2 that would normally be soaking it up is occupied by coronavirus particles. If that’s the problem, then increasing the amount of ACE-2 protein might paradoxically be just what you want to do to restore some balance to the angiotensin system. In that case administering more angiotensin receptor antagonists would be an effective way to upregulate the production of ACE-2. That second paper proposes sorting through the existing patient data to see if there are correlations between severity of infection and angiotensin receptor antagonist therapy in particular, and I believe that this is ongoing. Epithelial cells are going to have ACE-2 protein on their surfaces no matter what, so the virus is going to be attacking those as a route of entry. If that second paper is right, then it could be that throwing more ACE-2 onto those membrane doesn’t make the viral infection much worse, but does lessen the associated lung injury. If we’re going to have a lot more coronavirus patients, this would be a very good thing to know.” https://blogs.sciencemag.org/pipeline/archives/2020/03/17/angiotensin-and-the-coronavirus
“...according to studies conducted on mice, the interaction of the spike protein of the coronavirus with ACE2 induces a drop in the levels of ACE2 in cells through internalization and degradation of the protein and hence may contribute to lung damage.” "Both ACE inhibitors and angiotensin receptor blockers (ARBs) that are used to treat high blood pressure have been shown in rodent studies to upregulate ACE2 expression hence may affect the severity of coronavirus infections.[28][29] However, multiple regulatory bodies have recommended continuing standard ACE inhibitor and ARB therapy.[30] A systematic review and meta-analysis found that "use of ACE inhibitors was associated with a significant 34% reduction in risk of pneumonia compared with controls." and 'The risk of pneumonia was also reduced in patients treated with ACE inhibitors who were at higher risk of pneumonia, in particular those with stroke and heart failure. Use of ACE inhibitors was also associated with a reduction in pneumonia related mortality, although the results were less robust than for overall risk of pneumonia.' “ https://en.wikipedia.org/wiki/Angiotensin-converting_enzyme_2
Hey Thud, did you ever consider that if everyone around you was wearing a mask that prevented them from spreading the virus to you, you would not need N95, N98, or N99 masks?
The healthcare workers need these masks because they don’t know which patients are infected.
You really should donate your N95, N98 and N99 masks to them.
In the meantime, shelter in place until this effing government can provide enough simple surgical masks for everyone.
And stop posting to me - I’m tired of your BS.
The chart below may better explain where a ND/TD rate of 25% (roughly the US current rate) would take us, if the rate remained constant - which it won't.
Disclaimer: I'm in no way projecting these numbers to be the final outcome. These numbers are simply based on a single factor (there are many more to consider). And that factor (ND/TD) changes daily.
My personal "feelings" of how high the Coronavirus toll may eventually be, are based on a previously projected peak of around 15 April by "professional forecasters". I had felt we may see 100,000 deaths at the peak. During the ensuing down slope, I surmised that an additional 100,000 deaths may occur before the end the current outbreak.
Again, no epidemiologist here, just some IT nerd who has worked with data. My "feelings" are subject to change, the further this progresses. The closer to today's date the numbers are, the more accurate they will be.
RummyChick, have you read about any other genetic susceptibilities?
I keep hearing about these cases. We need an antibody test ASAP to get an idea of the incidence rate of recovered and reinfected. This is not an isolated incident. Coming from Korea is even more troubling.
I know, right? I actually talked a friend out of going to Mardi Gras, as it seemed pretty clear where we were heading. Multiple counties in California had “shelter in place” orders a week before Mardi Gras and events were being cancelled all over the place, but Mayor Cantrell had no idea?
"The mechanism of cough is likely multifactorial. ACE inhibitors prevent the breakdown of bradykinin and substance P, resulting in an accumulation of these protussive mediators ...." https://www.medscape.com/viewarticle/739521
"...although no study has explained the exact mechanism of the ACE-inhibitor cough, many experts think it is related to a natural compound called nitric oxide. ACE inhibitors cause the body to increase nitric oxide production, and nitric oxide is known to irritate the lungs and possibly cause coughing. Iron interferes with production of nitric oxide.” https://www.webmd.com/heart-disease/news/20010816/on-ace-inhibitor-you-dont-have-to-cough-up-lung#1
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.