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Team discovers that a derivative of vitamin B3 prevents liver cancer in mice
MedicalXpress.com ^ | November 20, 2014 | Centro Nacional de Investigaciones Oncologicas (CNIO)

Posted on 06/29/2018 7:45:13 PM PDT by ConservativeMind

Liver cancer is one of the most frequent cancers in the world, and with the worst prognosis...The most aggressive and frequent form of liver cancer is hepato-cellular carcinoma (HCC); little is known about it and there are relatively few treatment options.

Researchers from the Spanish National Cancer Research Centre (CNIO), have produced the first mouse model that faithfully reproduces the steps of human HCC development, from the appearance of the first lesions in the liver to the development of metastasis. The results, published in the prestigious journal Cancer Cell, indicate that diets rich in nicotinamide riboside, a derivative of vitamin B3, protect these mice from developing HCC in its most initial stage, when genotoxic stress is damaging cellular DNA. They also show a curative effect of the diet in those mice that had previously developed the disease.

The inverse relationship between NAD+ and cancer awakened the curiosity of the researchers: could an increase in NAD+ have beneficial effects on the disease? When the scientists supplemented the diet in genetically modified mice with nicotinamide riboside, a derivative of vitamin B3 that increases intracellular levels of NAD+, they did not observe tumour development. Surprisingly, when they gave this diet to mice that had already developed the disease, the size of the tumours was reduced and they eventually disappeared.

The results have been reproduced in other types of cancer such as pancreatic cancer.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer; cancercure; livercancer; nicotinamideriboside; pancreaticcancer; vitaminb
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To: ConservativeMind

Just saw this. Nevermind question.


21 posted on 06/29/2018 11:53:12 PM PDT by YogicCowboy ("I am not entirely on anyone's side, because no one is entirely on mine." - J. R. R. Tolkien)
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To: YogicCowboy

Yup. Post #8.


22 posted on 06/30/2018 3:11:52 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Save for later. Thank you.


23 posted on 06/30/2018 6:01:12 AM PDT by Lawgvr1955 ( Sic Semper Tyrannis)
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To: ConservativeMind

ping


24 posted on 06/30/2018 6:03:31 AM PDT by Victor (If an expert says it can't be done, get another expert." -David Ben-Gurion, the first Prime Minister)
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To: ConservativeMind

Of course... in my prayers...


25 posted on 06/30/2018 6:28:14 AM PDT by GOPJ (Sarah Sanders - kicked out of a resteraunt for the crime of 'eating while conservative'...)
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To: Irish Eyes

Bookmark


26 posted on 11/15/2018 7:56:43 AM PST by Irish Eyes
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To: sneakers

bookmark


27 posted on 11/15/2018 11:20:51 AM PST by sneakers (It's not the democraTIC party! It's the demoCRAT party!)
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To: ConservativeMind

Will investigate this weekend, thanks.


28 posted on 11/15/2018 11:58:05 AM PST by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
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To: azishot

SAVE


29 posted on 11/15/2018 4:24:42 PM PST by azishot
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To: ConservativeMind

For future reference.


30 posted on 11/15/2018 9:42:06 PM PST by matthew fuller (https://patriotpost.us/alexander/13407-the-battle-of-athens-tennessee)
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