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Tasmanian Devil Milk Kills Several Deadly Superbugs That Are Resistant to Existing Drugs
Science Alert ^

Posted on 11/16/2016 9:53:18 PM PST by nickcarraway

A whole new way to fight antibiotic resistance.

Scientists have discovered that Tasmanian devil milk contains an arsenal of antimicrobial compounds that can kill some of the most deadly bacterial and fungal infections known to science - including golden staph.

Tasmanian devils were found to produce six different types of these antimicrobial compounds - humans produce just one - and scientists were able to successfully synthesise them in the lab to test their effectiveness against a number of drug-resistant bacterial and fungal pathogens.

When tested against 25 different bacterial and six fungal strains, the six varieties of antimicrobial compounds were found to kill golden staph (Staphylococcus aureus) - responsible for food poisoning, pneumonia, and toxic shock syndrome - and Enterococcus, which can cause urinary tract infections and meningitis.

The compounds also killed Candida krusei - a rare yeast species associated with high mortality - and the deadly and hyper-virulent airborne fungus called Cryptococcus gattii.

"It was really exciting," one of the team, Emma Peel from the University of Sydney in Australia, told Bridie Smith at The Sydney Morning Herald. "We showed that these devil peptides kill multi-drug resistant bacteria, which is really cool."

For the uninitiated, Tasmanian devils are a species of carnivorous marsupial found in the wild only on the Australian island state of Tasmania. Around the size of a small dog, they’re the largest carnivorous marsupial in the world.

Tasmanian devils are currently under serious threat from devil facial tumour disease (DFTD) - a highly infectious parasitic facial cancer that’s wiped out more than 70 percent of the species.

But while this disease has been wreaking havoc on the population over the past two decades, it appears the species is actually developing its own resistance to DFTD.

And that's not the only indication of this Australian species' incredible toughness - Tasmanian devil joeys are born without primary immune tissues, and they don't develop proper antibody-mediated immunity until around 90 days old. And yet, somehow they survive their mother's pouch, which is positively teeming with bacteria.

Researchers aren't entirely sure how tiny, weak babies with lacking immune systems can survive such an environment, but antimicrobial peptides in their mother's milk and pouch lining could be key.

When Peel and her team scanned the Tasmanian devil’s genome and analysed the molecular structure of the milk, they found six naturally occurring antimicrobial peptides in the cathelicidins family that were "three to six times more effective" against a range of fungal infections than a common anti-fungal medication.

Two varieties of peptides - Saha-CATH5 and Saha-CATH6 - have been singled out for being particularly effective in killing bacteria that are harmful to humans.

"Of the six characterised cathelicidins, Saha-CATH5 and 6 have broad-spectrum antibacterial activity and are capable of killing problematic human pathogens," the team concludes.

With drug resistant infections expected to kill more people than cancer each year if things keep going as they are, we need a solution, and fast. The researchers are now investigating if the synthetic version of these peptides can be used safely in humans

"These peptides are killing superbugs, so there is potential for future development into antibiotics," Peel told ABC News.

"That is the next step for our research, to see if these peptides have anti-cancer potential, if they are killing superbugs maybe they could kill the facial tumour."

The study has been published in Scientific Reports.


TOPICS: Food; Health/Medicine; Science
KEYWORDS: animals; antibiotics; bacteria; innovation; sahacath5; taz; tazmaniandevil; tech; waveofthefuture
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To: right way right
I think Badger milk might be better.

You get to milk the first one, I'll get video of it all..............

21 posted on 11/16/2016 11:14:52 PM PST by doorgunner69
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To: moonhawk

hillary


22 posted on 11/16/2016 11:17:19 PM PST by Bob434
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To: nickcarraway

Man those critters are cute and that is coming from a dude.

Wonder if you can litter box train them. Just asking since I would have to keep them indoors. Wouldn’t want them getting out and killing ghetto pit bulls.


23 posted on 11/16/2016 11:19:16 PM PST by LesbianThespianGymnasticMidget (God punishes Conservatives by making them argue with fools. Go Trump!)
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To: Pontiac

Haha, now we know what became of Emma Peel.


24 posted on 11/16/2016 11:22:10 PM PST by UnwashedPeasant (I told you so)
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To: nickcarraway

DFTD - Devil Facial Tumour Disease

Isn’t that what Chelsea Clinton has?


25 posted on 11/16/2016 11:30:36 PM PST by Darteaus94025 (Can't have a Liberal without a Lie)
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To: moonhawk

I was going to ask the same thing.


26 posted on 11/16/2016 11:48:59 PM PST by OldNewYork (Operation Wetback II, now with computers)
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To: moonhawk
Yeah, but, who’s going to milk them?

^^Genius. This kind of thing is half the reason I love Freepers.

27 posted on 11/16/2016 11:51:34 PM PST by ottbmare (the OTTB mare, now a proud Marine Mom)
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To: doorgunner69; right way right

Honey badger....don’t do anything half assed


28 posted on 11/16/2016 11:51:48 PM PST by wardaddy (trump is a great tourniquet but that's all folks.......)
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To: Pontiac

..she got passed around....*smiles*


29 posted on 11/17/2016 12:21:53 AM PST by Doogle (( USAF.68-73..8th TFW Ubon Thailand..never store a threat you should have eliminated)))
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To: nickcarraway
Two French tourists who died within minutes of each other while snorkelling on the Great Barrier Reef are likely to have been stung by the Irukandji jellyfish
30 posted on 11/17/2016 12:22:59 AM PST by Berlin_Freeper
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To: nickcarraway

That’s what I was thinkin’


31 posted on 11/17/2016 1:22:13 AM PST by Bullish (The fly on Hillary's forehead knows)
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To: Doogle; UnwashedPeasant; crosdaddy

Although I like Uma Thurman I prefer Diana Rig in the roll of Emma Peel.

It could be just bad writing for the 1998 movie but Uma just did not work in the roll.


32 posted on 11/17/2016 1:40:38 AM PST by Pontiac (The welfare state must fail because it is contrary to human nature and diminishes the human spirit.)
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To: moonhawk

When when it be on Amazon?


33 posted on 11/17/2016 3:23:33 AM PST by wally_bert (I didn't get where I am today by selling ice cream tasting of bookends, pumice stone & West Germany)
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To: nickcarraway

Yeah but ever tried milking one while they are spinning?


34 posted on 11/17/2016 4:16:03 AM PST by DannyTN
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To: Osage Orange

Testing Weiner? Are you looking for antibodies or STDs?


35 posted on 11/17/2016 4:18:20 AM PST by DannyTN
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To: nickcarraway

There’s a great job opportunity. “ here, take this bucket and go milk the Tasmanian Devil.”


36 posted on 11/17/2016 4:18:57 AM PST by Jimmy Valentine (DemocRATS - when they speak, they lie; when they are silent, they are stealing the American Dream)
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To: moonhawk
Yeah, but, who’s going to milk them?

I understand that the females are extremely dangerous when they're angry.


37 posted on 11/17/2016 5:23:48 AM PST by Maceman (Screw the Party. Save the Country.)
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To: wardaddy

You get milk AND honey from a Honey Badger.


38 posted on 11/17/2016 5:41:18 AM PST by right way right (May we remain sober over mere men, for God really is our one and only true hope.)
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To: wardaddy

trust me.....do it.


39 posted on 11/17/2016 5:43:07 AM PST by right way right (May we remain sober over mere men, for God really is our one and only true hope.)
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To: right way right

LOL....and alot of stitches!


40 posted on 11/17/2016 5:59:31 AM PST by DCBryan1 (No realli, moose bytes can be quite nasti!)
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