Alzheimer's disease - a neurospirochetosis.

The Journal of NeuroInflamation ^ | August 4, 2011 | By Judith Miklossy, MD

[Swordmaker]

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.

Judith Miklossy
Correspondence: Judith Miklossy judithmiklossy@bluewin.ch

Journal of Neuroinflammation 2011, 8:90 doi:10.1186/1742-2094-8-90

Published: 4 August 2011
Abstract (provisional)

It is established that chronic spirochetal infection can cause slowly progressive dementia, brain atrophy and amyloid deposition in late neurosyphilis. Recently it has been suggested that various types of spirochetes, in an analogous way to Treponema pallidum, could cause dementia and may be involved in the pathogenesis of Alzheimer's disease (AD). Here, we review all data available in the literature on the detection of spirochetes in AD and critically analyze the association and causal relationship between spirochetes and AD following established criteria of Koch and Hill. The results show a statistically significant association between spirochetes and AD (P = 1.5 x 10-17, OR = 20, 95% CI = 8-60, N = 247). When neutral techniques recognizing all types of spirochetes were used, or the highly prevalent periodontal pathogen Treponemas were analyzed, spirochetes were observed in the brain in more than 90% of AD cases. Borrelia burgdorferi was detected in the brain in 25.3% of AD cases analyzed and was 13 times more frequent in AD compared to controls. Periodontal pathogen Treponemas (T. pectinovorum, T. amylovorum, T. lecithinolyticum, T. maltophilum, T. medium, T. socranskii) and Borrelia burgdorferi were detected using species specific PCR and antibodies. Importantly, co-infection with several spirochetes occurs in AD. The pathological and biological hallmarks of AD were reproduced in vitro. The analysis of reviewed data following Koch's and Hill's postulates shows a probable causal relationship between neurospirochetosis and AD. Persisting inflammation and amyloid deposition initiated and sustained by chronic spirochetal infection form together with the various hypotheses suggested to play a role in the pathogenesis of AD a comprehensive entity. As suggested by Hill, once the probability of a causal relationship is established prompt action is needed. Support and attention should be given to this field of AD research. Spirochetal infection occurs years or decades before the manifestation of dementia. As adequate antibiotic and anti-inflammatory therapies are available, as in syphilis, one might prevent and eradicate dementia.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

[novemberslady]

bkmk
And thank you very much for posting this.

[thesearethetimes...]

‘nother bookmark ;)

Thanks much for giving us a little something more to look into :)
Tatt

[thesearethetimes...]

I have been looking, but so far, finding the ingredient lists for other brands is tough : /

Soooo, other than Sodium Hypochlorite, what ingredients are “safe” and were in the old Clorox formula?

Also, should I come across a simple bleach brand, what percentage of Sodium Hypochloride should we be looking for, (again, maybe what was in the old Clorox formula?) before we reduce it down to the 20-1 Dakin’s formula?

Thanks much and may God bless!

[Swordmaker]

Good NEWS!

Clorox posted another Clorox product last night called Clorox™ Germicidal which my main doctor just got back to me on. It is basically the same as the original product with safe buffering chemicals added to allow it to last longer in the bottle. He's reviewed them and finds them OK in the percentages they are in the mix. This is the ONLY one that is OK to use. . . none of the others should be used. As you notice it has the same damn blue cap as all the rest!

It is still concentrated, so the amount of Sodium Hypochlorite in it is 8.25% not 7%. Use 24 capfuls of water to one capful of Clorox Germicidal.

Finding it may be a bit more difficult. . . Costco carries a 3-pack for about $8.42, but your local grocery or hardware may not have it. Do NOT use any of the others, only the Clorox™ Germicidal version.

[novemberslady]

Thanks for the update
Bttt

[thesearethetimes...]

Yay!
Thanks much, and may God bless :)

Tatt

[Auntie Mame]

Related thread.....
http://www.freerepublic.com/focus/chat/3341658/posts

[thesearethetimes...]

Thanks much! I just ordered some of the germicidal version from Amazon :)

Blessings!
Tatt

[dennisw]

I’d imagine the Clorox dilution would be even more fantastic if used in one’s Water-Pik. Gets into the gums that way!

That's what we recommend.

Do you do this? My sister does though she did it more often in the beginning to get rid of plaque and teeth that were getting problems from bacteria below the gum line. She had success. I think I might start myself plus brushing with baking soda

My sister saved thousands on exotic laser treatments etc for what she had....all with the bleach+water pik methode

[TNoldman]

Ping

[Swordmaker]

I’d imagine the Clorox dilution would be even more fantastic if used in one’s Water-Pik. Gets into the gums that way!

That's what we recommend.

Do you do this? My sister does though she did it more often in the beginning to get rid of plaque and teeth that were getting problems from bacteria below the gum line. She had success. I think I might start myself plus brushing with baking soda

My sister saved thousands on exotic laser treatments etc for what she had....all with the bleach+water pik methode

yes. It is the best way to get the anti-microbial action down into the spaces in the gum line where it is really most effective. Once you get control of the sheer numbers of bacteria, you really don't need to do it quite as often. You'll find you like the feeling it gives your mouth. Just always remake the solution daily and watch the dilution. The Blue Cap method of getting the right type of Clorox no longer works. Clorox dropped that coding a couple of years ago and ALL versions of Clorox come with the same dark blue cap now. Get the anti-bacterial version if Clorox if you can find it. . . If not, don't worry too much about other contaminating additions. At 20 to 1, the small additions will not amount to much. Just don't get one that is a detergent with Clorox added.

[dennisw]

Thanks ... I know where to get no frills bleach. Home Depot and Lowes and Aldi’s....All bleach seems to ship in a more concentrated form than a few years ago.

So you personally still brush with baking soda? And you use bleach in a water pick once in a while?
With one capful of bleach diluted with 24 capfuls water?

Yeah I read your update on blue cap Clorox... how they put additives in it these days

[Swordmaker]

Thanks ... I know where to get no frills bleach. Home Depot and Lowes and Aldi’s....All bleach seems to ship in a more concentrated form than a few years ago.

We really don't recommend any brand except Clorox. The others are not certified for health use. . . because they aren't made to the standard of the Clorox brand. The concentrations can vary by quite a bit from the 7% Sodium Hypoclorite the Clorox is sold at. It's better to use a known starting concentration than take chances with an off brand. Even Clorox increased their concentration a few years ago without warning. That's why the update to 24 capfuls to account for that change in concentration.

[dennisw]

My sister saved thousands on exotic laser treatments etc for what she had....all with the bleach+water pik method

yes. It is the best way to get the anti-microbial action down into the spaces in the gum line where it is really most effective

My sister almost went through the rip-off mill with these dentists that treat Periodontal (Gum) Disease:     Thee guys are raking in thousands at one shot for laser treatments and peeling back gums (grisly!) and scraping

My sister had just four problem teeth but these dentists wanted to treat her entire mouth to make the thousands they are used to.. Finally she found a dentist who was a two hour drive away who was nice enough to do the laser treatment on just her four teeth that needed it. She then took care of everything else by dedicated irrigation with the diluted bleach water you are familiar with

[dennisw]

We really don't recommend any brand except Clorox. The others are not certified for health use. . . because they aren't made to the standard of the Clorox brand. The concentrations can vary by quite a bit from the 7% Sodium Hypoclorite the Clorox is sold at. It's better to use a known starting concentration than take chances with an off brand. Even Clorox increased their concentration a few years ago without warning. That's why the update to 24 capfuls to account for that change in concentration. 

Thanks! I will nail down the particulars. What type of Clorox is best? You said the germicidal kind?

[Swordmaker]

Thanks! I will nail down the particulars. What type of Clorox is best? You said the germicidal kind?

Yes. It's straight Sodium HypoChlorite and water in solution which you will dilute even more, no laundry additives.

[Swordmaker]

Let me correct that last one. . . there are some buffering chemicals to allow it to keep longer at the correct dilution but they will not have any deleterious effect on anything. The concentration of those, especially after the 24 to 1 additional dilution will be below the level of them having any effect at all.

[Ditter]

This is extremely interesting, thanks. I have brushed my teeth with baking soda for many years. Tooth paste, any brand, started to make my mouth sore, so I stopped using it altogether. I didn’t know about the Clorox!

[Swordmaker]

This is extremely interesting, thanks. I have brushed my teeth with baking soda for many years. Tooth paste, any brand, started to make my mouth sore, so I stopped using it altogether. I didn’t know about the Clorox!

The formula for mixing the Clorox has changed since they're now only selling a concentrated version of their products. Also the instructions about using the "blue cap" version is no longer true as all Clorox versions have the same color blue cap now. Check toward the end of the thread for details. Essentially, the new proportions are 24 to 1 and the best type of Clorox is now called "Clorox Germicidal."

[Right-wing Librarian]

I believe you posted this several years ago, and like a naive innocent, I believed you and ruined my teeth.

Before doing this, I verified with you that it would be safe to use on my whole mouth restoration set of teeth. You assured me it would be safe.

After one time, it took the enamel off my ceramic restoration, ate away at the “gum” paortions, and put a permanent brown stain where the top of the enamels meet the “gum” line.

My ^70,000 investment was ruined.