Posted on 04/21/2010 10:06:16 AM PDT by decimon
Johns Hopkins researchers discover pathway in mice for resveratrol's apparent protective effect
Researchers at Johns Hopkins say they have discovered the way in which red wine consumption may protect the brain from damage following a stroke.
Two hours after feeding mice a single modest dose of resveratrol, a compound found in the skins and seeds of red grapes, the scientists induced an ischemic stroke by essentially cutting off blood supply to the animals' brains. They found that the animals that had preventively ingested the resveratrol suffered significantly less brain damage than the ones that had not been given the compound.
Sylvain Doré, Ph.D., an associate professor of anesthesiology and critical care medicine and pharmacology and molecular sciences at the Johns Hopkins University School of Medicine, says his study suggests that resveratrol increases levels of an enzyme (heme oxygenase) already known to shield nerve cells in the brain from damage. When the stroke hits, the brain is ready to protect itself because of elevated enzyme levels. In mice that lacked the enzyme, the study found, resveratrol had no significant protective effect and their brain cells died after a stroke.
"Our study adds to evidence that resveratrol can potentially build brain resistance to ischemic stroke," says Doré, the leader of the study, which appears online in the journal Experimental Neurology.
Red wine has gotten a lot of attention lately for its purported health benefits. Along with reducing stroke, moderate wine consumption has been linked to a lowered incidence of cardiovascular disease — the so-called French paradox. Despite diets high in butter, cheese and other saturated fats, the paradox goes, the French have a relatively low incidence of cardiovascular events, which some have attributed to the regular drinking of red wine.
Doré cautions against taking resveratrol supplements, available alongside vitamins and minerals and on websites touting its benefits, because it is unclear whether such supplements could do harm or good. He has not tested resveratrol in clinical trials. And while resveratrol is found in red grapes, it's the alcohol in the wine that may be needed to concentrate the amounts of the beneficial compound. Doré also cautions that drinking alcohol carries risks along with potential benefits.
He also notes that even if further research affirms the benefits of red wine, no one yet knows how much would be optimal to protect the brain, or even what kind of red wine might be best, because not all types contain the same amount of resveratrol. More research is needed, he says.
Doré says his research suggests that the amount needed could end up being quite small because the suspected beneficial mechanism is indirect. "Resveratrol itself may not be shielding brain cells from free radical damage directly, but instead, resveratrol, and its metabolites, may be prompting the cells to defend themselves," he suggests.
"It's not likely that brain cells can have high enough local levels of resveratrol to be protective," he says. The resveratrol is needed to jump-start this protective enzymatic system that is already present within the cells. "Even a small amount may be sufficient," Doré says.
Doré says his ongoing research also suggests some therapeutic benefits to giving resveratrol to mice after a stroke to limit further neuronal damage.
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The research was supported in part by grants from the National Institutes of Health, the Wine Institute and the ABMR Foundation.
Other Johns Hopkins authors of the study include Hean Zhuang, M.D.; Herman Kwansa, Ph.D; and Raymond C. Koehler, Ph. D.
Works for me, never had a stroke.
Whiff of grape ping.
Same here.......
Will open a nice red Zin to celebrate the news.
UB40 may have been onto something back then.
“More research is needed, he says.”
Oh, pick me, pick me! :) It’s the least I can do to help my fellow citizens!
I will do research tonight.
Shields up!
Wheee! May have to pick up a nice Merlot tonight...Just to stave off any potential strokes.
Well, OK then. I guess I’d better make sure I get the proper amount of “medicine,” so I won’t have a stroke.
Had a nice Argentine Malbec the other evening.........
Fancy meeting you on a wine thread......I might never have guessed.
:-)
LOL
Merlot, cab sauv and shiraz....yeah, baby!
My parents really got into it when we were stationed in Italy when I was a kid. I used to travel to Argentina for work and discovered those (rather robust) Mendoza Valley wines.
I'm no expert, but I know what I like. :)
The best kind of expert.
Actually, Neil Diamond wrote it.
Yes, but UB40 made the song famous.
Neil Diamond music was the type of stuff my parents always listened to. Ugh.
Neil’s 60s stuff actually was pretty good, before he got all schmaltzy in the 70s.
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