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Florida Biochemist designs a citrus tree with THC
The Crit ^ | 05 Oct 2008 | The Crit

Posted on 01/05/2009 8:07:50 AM PST by BGHater

In the summer of 1984, 10th-grader Irwin Nanofsky and a friend were driving down the Apalachee Parkway on the way home from baseball practice when they were pulled over by a police officer for a minor traffic infraction.


After Nanofsky produced his driver’s license the police officer asked permission to search the vehicle. In less than two minutes, the officer found a homemade pipe underneath the passenger’s seat of the Ford Aerostar belonging to the teenage driver’s parents. The minivan was seized, and the two youths were taken into custody on suspicion of drug possession.

Illegal possession of drug paraphernalia ranks second only to open container violations on the crime blotter of this Florida college town. And yet the routine arrest of 16 year-old Nanofsky and the seizure of his family’s minivan would inspire one of the most controversial drug-related scientific discoveries of the century.

Meet Hugo Nanofsky, biochemist, Florida State University tenured professor, and the parental authority who posted bail for Irwin Nanofsky the night of July 8, 1984. The elder Nanofsky wasn’t pleased that his son had been arrested for possession of drug paraphernalia, and he became livid when Tallahassee police informed him that the Aerostar minivan would be permanently remanded to police custody.

Over the course of the next three weeks, Nanofsky penned dozens of irate letters to the local police chief, the Tallahassee City Council, the State District Attorney and, finally, even to area newspapers. But it was all to no avail.

Under advisement of the family lawyer, Irwin Nanofsky pled guilty to possession of drug paraphernalia in order to receive a suspended sentence and have his juvenile court record sealed. But in doing so, the family minivan became “an accessory to the crime.” According to Florida State law, it also became the property of the Tallahassee Police Department Drug Task Force. In time, the adult Nanofsky would learn that there was nothing he could do legally to wrest the vehicle from the hands of the state.

It was in the fall of 1984 that the John Chapman Professor of Biochemistry at Florida State University, now driving to work behind the wheel of a used Pontiac Bonneville, first set on a pet project that he hoped would “dissolve irrational legislation with a solid dose of reason.” Nanofsky knew he would never get his family’s car back, but he had plans to make sure that no one else would be pulled through the gears of what he considers a Kafka-esque drug enforcement bureaucracy.

“It’s quite simple, really,” Nanofsky explains, “I wanted to combine Citrus sinesis with Delta 9-tetrahydrocannabinol.” In layman’s terms, the respected college professor proposed to grow oranges that would contain THC, the active ingredient in marijuana. Fourteen years later, that project is complete, and Nanofsky has succeeded where his letter writing campaign of yore failed: he has the undivided attention of the nation’s top drug enforcement agencies, political figures, and media outlets.

The turning point in the Nanofsky saga came when the straight-laced professor posted a message to Internet newsgroups announcing that he was offering “cannabis-equivalent orange tree seeds” at no cost via the U.S. mail. Several weeks later, U.S. Justice Department officials showed up at the mailing address used in the Internet announcement: a tiny office on the second floor of the Dittmer Laboratory of Chemistry building on the FSU campus. There they would wait for another 40 minutes before Prof. Nanofsky finished delivering a lecture to graduate students on his recent research into the “cis-trans photoisomerization of olefins.”

“I knew it was only a matter of time before someone sent me more than just a self-addressed stamped envelope,” Nanofsky quips, “but I was surprised to see Janet Reno’s special assistant at my door.” After a series of closed door discussions, Nanofsky agreed to cease distribution of the THC-orange seeds until the legal status of the possibly narcotic plant species is established.

Much to the chagrin of authorities, the effort to regulate Nanofsky’s invention may be too little too late. Several hundred packets containing 40 to 50 seeds each have already been sent to those who’ve requested them, and Nanofsky is not obliged to produce his mailing records. Under current law, no crime has been committed and it is unlikely that charges will be brought against the fruit’s inventor.

Now it is federal authorities who must confront the nation’s unwieldy body of inconsistent drug laws. According to a source at the Drug Enforcement Agency, it may be months if not years before all the issues involved are sorted out, leaving a gaping hole in U.S. drug policy in the meantime. At the heart of the confusion is the fact that THC now naturally occurs in a new species of citrus fruit.

As policy analysts and hemp advocates alike have been quick to point out, the apparent legality (for now) of Nanofsky’s “pot orange” may render debates over the legalization of marijuana moot. In fact, Florida’s top law enforcement officials admit that even if the cultivation of Nanofsky’s orange were to be outlawed, it would be exceedingly difficult to identify the presence of outlawed fruit among the state’s largest agricultural crop.

Amidst all of the hubbub surrounding his father’s experiment, Irwin Nanofsky exudes calm indifference. Now 30-years-old and a successful environmental photographer, the younger Nanofsky can’t understand what all of the fuss is about. “My dad’s a chemist. He makes polymers. I doubt it ever crossed his mind that as a result of his work tomorrow’s kids will be able to get high off of half an orange.”

Biochem 101: How to design a Cannabis-equivalent citrus plant

Step One:
Biochemically isolate all the required enzymes for the production of THC.

Step Two:
Perform N-terminal sequencing on isolated enzymes, design degenerate PCR (polymerase chain reaction) primers and amplify the genes.

Step Three:
Clone genes into an agrobacterial vector by introducing the desired piece of DNA into a plasmid containing a transfer or T-DNA. The mixture is transformed into Agrobacterium tumefaciens, a gram negative bacterium.

Step Four:

Use the Agrobacterium tumefaciens to infect citrus plants after wounding. The transfer DNA will proceed to host cells by a mechanism similar to conjugation. The DNA is randomly integrated into the host genome and will be inherited.


TOPICS: Gardening; Science; Society
KEYWORDS: citrus; controlledsubstance; dna; dopersrights; fakebutaccurate; florida; floriduh; hoax; isureshowedthemhuh; janetreno; justicedepartment; narcotics; thc; thcoranges
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To: TornadoAlley3
Maybe not !! There were supposedly some bio students at Penn State that successfully gene spliced cannibas genes into ordinary hedge plants in the late 80’s. Trim the hedges and smoke the tailings .
41 posted on 01/05/2009 8:41:38 AM PST by Renegade (You go tell my buddies)
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To: MarineBrat

Yeh,...go ahead with that.After all so many kids don’t do drugs because their parents did, they are rebelling. The ghettos , trailer parks, and ivy league communities are full of kids gone straight because of their parents hahahahahahah.


42 posted on 01/05/2009 8:44:08 AM PST by redstateconfidential (" An American Idol President")
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To: Drew68

Or, maybe his little punk for a son should have not had drug paraphernalia in the van — and he should have been a better father made the little POS learn his lesson and pay for it and bought the family a new van — “don’t do the crime if you can’t do the time!” But, then again, “Stupid is as stupid does.”


43 posted on 01/05/2009 8:46:16 AM PST by areukiddingme1 (areukiddingme1 is a synonym for a Retired U.S. Navy Chief Petty Officer and tired of liberal BS.)
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To: BGHater

Appalachee Pkwy heads straight toward the Capitol building as you’re coming into Tallahassee. Even back in the early 70s when I was in school there, it was a beautiful drive at night with the lighting on the Parkway and with the State Capitol lit up. In those days there was no practical test for THC in the bloodstream for drivers, so getting a DUI for pot was not something anyone worried about. Did I say the Capitol building was lit up? Well, it wasn’t alone (and that really was a beautiful drive back into town).


44 posted on 01/05/2009 8:48:01 AM PST by Stevenc131
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To: BGHater

Hilarious.

I can’t stand drug warriors (and, no, I don’t use drugs). Their misguided do-goodery has put a huge internal police force in place that will be used against the population.

You cannot legislate morality.


45 posted on 01/05/2009 8:57:41 AM PST by MeanWestTexan (Beware Obama's Reichstag fire.)
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To: BGHater

It would appear that revenge is a dish best sipped cold at the breakfast table!!! Please pass the OJ


46 posted on 01/05/2009 8:57:53 AM PST by NonValueAdded (once you get to really know people, there are always better reasons than [race] for despising them.)
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To: redstateconfidential

I respectfully disagree.

Destroying drug laws is a wonderful thing.


47 posted on 01/05/2009 8:58:41 AM PST by MeanWestTexan (Beware Obama's Reichstag fire.)
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To: Renegade
Maybe not !! There were supposedly some bio students at Penn State that successfully gene spliced cannibas genes into ordinary hedge plants in the late 80’s. Trim the hedges and smoke the tailings .

I believe something similar was done by Carl Spackler.

48 posted on 01/05/2009 8:58:47 AM PST by Moonman62 (The issue of whether cheap labor makes America great should have been settled by the Civil War.)
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To: BGHater

Wow, this is so hilarious.


49 posted on 01/05/2009 8:59:27 AM PST by SaintDismas
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To: Renegade
Didn't they sell those for awhile?


50 posted on 01/05/2009 9:00:56 AM PST by weegee (Obamunism, just another word for the policies of a NeoCom.)
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To: jwparkerjr
Wonder if he can patent the process. I didn’t see any mention of patents in the article, but I read through it pretty quickly.

It would be like patenting mowing the lawn. It's standard technique.
51 posted on 01/05/2009 9:01:48 AM PST by aruanan
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To: Vigilanteman
Their reasoning: If they successfully commercialized the formula, the state would just cut their appropriation.

Different states, and even different universities within each state, might reason differently on such matters. At the University of Wisconsin at Madison, they have an alumni group with full-time patent agents on the payroll, filing patent applications on behalf of the university. They're awarded about 70 patents in a typical year.

Wisconsin Alumni Research Foundation

As you can see from reading the story, even 77 patents in 2005 ranks them as only the fifth most productive university in the United States in acquiring patents: "Listed ahead of UW-Madison were the 10 campuses of the University of California System, with 390 patents; the Massachusetts Institute of Technology, with 136 patents; the California Institute of Technology, with 101 patents; and Stanford University and the University of Texas, which tied for fourth with 90 patents each."

52 posted on 01/05/2009 9:01:57 AM PST by Philo1962 (Iraq is terrorist flypaper. They go there to die.)
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To: NonValueAdded
Ok, you can keep him...


53 posted on 01/05/2009 9:02:40 AM PST by weegee (Obamunism, just another word for the policies of a NeoCom.)
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To: redstateconfidential
What a jackass, [sic] all that effort because his sons [sic] a pothead.Typical irrational liberal behavior in otherwise “booksmart” people.

Go back and read the article and then correct your first sentence above.
54 posted on 01/05/2009 9:04:25 AM PST by aruanan
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To: mysterio
police informed him that the Aerostar minivan would be permanently remanded to police custody.

Absolute insanity. We have given up our privacy and property rights to this stupid failed drug war.

You ain't seen nothing yet. The Coast Guard seized a yacht worth about $250,000 after they found a roach (remnant of a marijuana joint) in one of the ashtrays. Seizing cars like the professor's minivan is fairly routine. Even private aircraft have been seized. Asset forfeiture laws are an invitation for the abuse of government power.

55 posted on 01/05/2009 9:07:13 AM PST by Philo1962 (Iraq is terrorist flypaper. They go there to die.)
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To: posterchild

lmao...


56 posted on 01/05/2009 9:07:15 AM PST by sit-rep
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To: weegee

bttt


57 posted on 01/05/2009 9:09:21 AM PST by ConservativeMan55
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To: aruanan
I'm sorry this is the last time checking my mail today, I have to go to work, I won't be needing my magnifying glass, would you like to compare it to yours while I'm gone?Magnifying Glass / Bill Of Rights Pictures, Images and Photos
58 posted on 01/05/2009 9:14:15 AM PST by redstateconfidential (" An American Idol President")
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To: weegee

I thought so , but only grew in certain climes like W Va. Was a while ago . Now all people have to do is go to Mass. (as of 1/1/09) and smoke your brains out . No crime under 1 oz. and a hundred $ fine if caught ?
Just imagine how much money would be saved by decriminalizing THC and clear1ng out the jails of really harmless people arrested for toking .


59 posted on 01/05/2009 9:54:12 AM PST by Renegade (You go tell my buddies)
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To: Renegade

Just imagine how much money would be saved if our judges and legislators were not funded by lawyers who pay to get the laws that will keep them in business.


60 posted on 01/05/2009 9:57:10 AM PST by weegee (Obamunism, just another word for the policies of a NeoCom.)
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