Posted on 09/16/2021 5:57:27 PM PDT by Roman_War_Criminal
As the world wrestles with the COVID pandemic, just about the last thing that we need is for an even deadlier pandemic to suddenly break out. So the fact that a confirmed case of the Nipah virus has just prompted authorities in India to completely lock down a two mile area is causing a lot of panic right now. The Nipah virus has a mortality rate that is similar to Ebola, but it is a respiratory virus that can spread fairly easily through human contact. The good news is that past outbreaks have always been contained, and so we have never seen a full-blown Nipah pandemic. But the bad news is that if this virus escapes containment the death toll could potentially be staggering.
In past Nipah outbreaks, it has been confirmed that human to human transmission does happen…
In Siliguri, India in 2001, transmission of the virus was also reported within a health-care setting, where 75% of cases occurred among hospital staff or visitors. From 2001 to 2008, around half of reported cases in Bangladesh were due to human-to-human transmission through providing care to infected patients.
After all these years, could Nipah have mutated into a form that is even more easy to transmit?
At this moment, that is a question that we do not have an answer to.
The symptoms of the virus are similar to the common cold at first, but then they rapidly become a lot more serious. The following comes from the World Health Organization…
Infected people initially develop symptoms including fever, headaches, myalgia (muscle pain), vomiting and sore throat. This can be followed by dizziness, drowsiness, altered consciousness, and neurological signs that indicate acute encephalitis. Some people can also experience atypical pneumonia and severe respiratory problems, including acute respiratory distress. Encephalitis and seizures occur in severe cases, progressing to coma within 24 to 48 hours.
The incubation period (interval from infection to the onset of symptoms) is believed to range from 4 to 14 days. However, an incubation period as long as 45 days has been reported.
The fact that the virus has such a long incubation period is a huge concern.
Just a few days ago, a 12-year-old boy in India died from the virus, and authorities are scrambling to track down everyone that he had contact with…
Health officials in India are trying to stop the spread of yet another serious infectious disease. Over the weekend, a 12-year-old boy died from an infection caused by the Nipah virus, a highly lethal germ spread from bats or contaminated food that can also spread between people. Hundreds of people potentially exposed to the boy have been contacted, monitored, or placed under quarantine, including his close family.
Sadly, two health workers that the boy had been in contact with are “already showing symptoms”, and a two mile area around the home where the boy lived has been completely locked down…
Two healthcare workers who came into contact with the victim were already showing symptoms of Nipah infection by Monday. They were admitted to a hospital and their blood samples sent for testing.
Authorities sealed off the area within about a two-mile radius of the boy’s home, and they were screening people for symptoms in all adjoining districts of Kerala state. The neighboring state of Tamil Nadu was also on high alert for any suspect cases of fever.
We shall see what happens from here.
Hopefully authorities have been able to contain this outbreak in time.
But what if they haven’t?
According to the WHO, this virus does have “pandemic potential”, and the death rate during past outbreaks has been as high as 75 percent.
And Paul Joseph Watson has noted that the Nipah virus “was the inspiration for the movie Contagion”.
There is no cure for the Nipah virus and there is no vaccine.
So the only hope is containment.
As I have said so many times before, I believe that we are entering an era of great pestilences.
Despite all of our advanced technology, COVID has shown us how exceedingly vulnerable we really are.
And it is just a matter of time before a pandemic that is far more severe than COVID comes along.
Hopefully this is not it.
” Fauci, “let me sample that nipah for gain of function.” “
Fauci: “We must gain of function this virus, and aerosolize it in cans that look just like deodorant, so we can...uh...study it. Yeah, that’s it. Study it. So Science can protect all the stupid people. Yeah...study it. “
I’d be quarantining every population control freak on the books ... send ‘em all to Australia ... they’re already f***ed anyway.
No, this was named after a village in Malaysia.
“named after a village in Malaysia”
Well, we’ll just have to see what WHO says about that!
Welcome to your new ADE future, they just announced the new fear porn and the second part of their binary bioweapon.
ping!!
Yikes!
PING
PLEASE do not tell Fauci!
Turn loose the murder hornets!
Virus’s Achilles’ Heel Revealed
By Martin Enserink
ScienceNOW Daily News
18 February 2009
Vienna, Austria—Scientists have made a discovery about the basic biology of the Nipah virus, which suggests that cheap, existing drugs for high blood pressure and malaria may help fight the disease.
In Bangladesh, the virus appears to spread via date palm sap, which is collected overnight in clay pots tied around the tree trunk and sold fresh in the morning. Fruit bats are known to visit the trees to feed, and their urine and feces can end up in the pots.
No vaccines or drugs against Nipah exist. But now, a group led by Robin Buckland of INSERM in Lyons, France, may have found Nipah’s weak spot. Most researchers have assumed that the virus enters host cells through fusion between the cell’s plasma membrane and the virus’s envelope—a process that starts when a virus protein called G latches onto a host receptor called ephrinB2. But the INSERM team discovered that instead, the virus enters the cell through macropinocytosis, an ingestion process in which the cell membrane folds inward, engulfing the virus and its receptor in an intracellular vesicle.
Armed with that knowledge, the team tested out three drugs: Amiloride, which is used to treat hypertension and is known to block macropinocytosis; and the antimalarials chloroquine and hydroxychloroquine, which the team suspected might hamstring the virus because they raise the pH in intracellular compartments, including the vesicles created by macropinocytosis. In cell cultures, they found, all three drugs block viral replication efficiently. The team will start testing the drug in hamsters in a few weeks, says Olivier Pernet, a Ph.D. student in the group.
But tests in humans could begin even before the outcomes are known. “We’re very excited by these results,” says Stephen Luby, who studies Nipah at the International Centre for Diarrhoeal Disease Research in Bangladesh. Luby says he and others are already preparing a study protocol to try at least one of the drugs the next time Nipah strikes.
Given its high fatality rate and the fact that the drugs are quite safe, it probably would be unethical to conduct a randomized trial, in which half of the patients receive a placebo, Luby says. Instead, all of the patients that can be reached would receive treatment, he says, and their recovery rate would be compared with past experience.
This is a 2009 article and here is an interesting quote:
“Armed with that knowledge, the team tested out three drugs:
Amiloride, which is used to treat hypertension and is known to block macropinocytosis;
and the antimalarials chloroquine and hydroxychloroquine, which the team suspected might hamstring the virus because they raise the pH in intracellular compartments, including the vesicles created by macropinocytosis.
In cell cultures, they found, all three drugs block viral replication efficiently. “
Biology of Adenovirus Cell Entry
Stefania Luisoni, Urs F. Greber, in Adenoviral Vectors for Gene Therapy (Second Edition), 2016
4.2 Macropinocytosis
Macropinocytosis is the engulfment and uptake process of large amounts of fluids and membranes.
It occurs by actin-dependent membrane protrusion and retraction, and results in large intracellular vacuoles (>0.2 μM), referred to as macropinosomes, which can mature to late endosomes.
Constitutive macropinocytosis contributes to antigen presentation in macrophages and dendritic cells, and is widely exploited by pathogens to modulate the immune response.
Pinocytosis (Cell Drinking)
Pinocytosis (“pino” means “to drink”) is a process by which the cell takes in the fluids along with dissolved small molecules. In this process, the cell membrane folds and creates small pockets and captures the cellular fluid and dissolved substances.
I found this old article that ties high cholesterol and the cytokine storm response:
The inflammatory cytokine response of cholesterol-enriched macrophages is dampened by stimulated pinocytosis
Yankun Li et al. J Leukoc Biol. 2007 Feb.
Is this the link between obese people and the higher deaths in Covid-19?
I hear that there is a clinic in Beijing which has a record of 100% cures for everybody who goes there with Nipah Virus infection.
I hope hundreds of the Nipah infected from India go there for treatment.Good for China in helping out the “Vorld!”
I’d be quarantining every population control freak on the books ... send ‘em all to Australia ... they’re already f***ed anyway.>>>>>>>>>>>>>>>>>>>
Not funny at all.
Oh, thanks.
Ok, can we just nuke all of Asia yet?
Biden White House: “We think we should import these infected people, for humanitarian reasons, into the United States. Only racists would object.”
Makes sense...
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.