This is a 2009 article and here is an interesting quote:
“Armed with that knowledge, the team tested out three drugs:
Amiloride, which is used to treat hypertension and is known to block macropinocytosis;
and the antimalarials chloroquine and hydroxychloroquine, which the team suspected might hamstring the virus because they raise the pH in intracellular compartments, including the vesicles created by macropinocytosis.
In cell cultures, they found, all three drugs block viral replication efficiently. “
Biology of Adenovirus Cell Entry
Stefania Luisoni, Urs F. Greber, in Adenoviral Vectors for Gene Therapy (Second Edition), 2016
4.2 Macropinocytosis
Macropinocytosis is the engulfment and uptake process of large amounts of fluids and membranes.
It occurs by actin-dependent membrane protrusion and retraction, and results in large intracellular vacuoles (>0.2 μM), referred to as macropinosomes, which can mature to late endosomes.
Constitutive macropinocytosis contributes to antigen presentation in macrophages and dendritic cells, and is widely exploited by pathogens to modulate the immune response.