Researchers are closer to understanding what drives the autoimmune disorder Sjögren's disease. Their study finds that impaired regulatory T cells are a critical contributing factor to Sjögren's disease in both mice and humans, and identifies an existing rheumatology drug as a promising therapy. In Sjögren's disease, the immune system attacks the glands that produce saliva and tears, resulting in dry mouth and eyes. While there is no cure for Sjögren's disease, some treatments alleviate symptoms. Feske and Lacruz undertook two studies focusing on different tissues—salivary gland cells and immune cells. They specifically looked at cells lacking the Stim1 and Stim2...