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Paxlovid can lessen the chance of a severe COVID-19 illness. Why is it underused?
Breitbart ^ | 02/07/2024 | AP

Posted on 02/07/2024 8:10:26 AM PST by ChicagoConservative27

Tens of thousands of Americans are hospitalized with COVID-19 every week. Thousands die from it every month. And yet, an antiviral treatment proven to lessen the chances of severe outcomes is going underused.

The drug, Paxlovid, is lauded by experts as a powerful tool that can prevent hospitalization and death from COVID-19. But the high price and doctors’ hesitation to prescribe the pills mean the five-day treatment isn’t getting to everyone who would benefit from it.

“When you read in your local newspaper that in this hospital, they’ve got this many COVID patients, most of those are preventable hospitalizations,” said Dr. Amesh Adalja, a senior scholar at Johns Hopkins University who sees Paxlovid as a useful tool to treat COVID-19.

(Excerpt) Read more at breitbart.com ...


TOPICS: Business/Economy; Culture/Society; News/Current Events; Your Opinion/Questions
KEYWORDS: covid; covid19; illness; paxlovid; severe; variants
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To: ChicagoConservative27

Breitbart’s posting this disinfo?


21 posted on 02/07/2024 8:25:07 AM PST by 9YearLurker
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To: ChicagoConservative27
Paxlovid just pushes the "pause" button on a COVID infection. It actively disables the protease that is required to cleave the polypeptide generated from the mRNA template into individual, functional protein sub-units. When the Paxlovid inhibitor is exhausted, the backlog of polypeptide is rapidly processed into functional protein subunits. The user experiences a severe rebound/relapse of symptoms.

An anecdotal report from a user on X revealed the Paxlovid made her feel so much better that she resumed jogging 5 miles. When the course of tablets was complete and the onboard dose exhausted, her symptoms were far worse than before taking the Paxlovid. Her doctor monitored her closely before, during and after the doses. Some lab work before and after looked worse. It was decided to avoid future use of Paxlovid for her specific case.

22 posted on 02/07/2024 8:25:11 AM PST by Myrddin
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To: Shady

My high tech Covid medical cure was orange juice and aspirin.

Worked like a charm. Twice.


23 posted on 02/07/2024 8:25:20 AM PST by Texas resident (Biden=Obama=Jarrett=Soros)
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To: ChicagoConservative27

24 posted on 02/07/2024 8:25:22 AM PST by ransomnote (IN GOD WE TRUST)
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To: ChicagoConservative27
Perhaps the medical "profession" has earned our loss of trust?
25 posted on 02/07/2024 8:26:46 AM PST by null and void (I identify as a conspiracy theorist. My personal pronouns are told/you/so.)
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To: ChicagoConservative27

Because it costs $1500 and the dose and duration of treatment are wrong.


26 posted on 02/07/2024 8:27:00 AM PST by Jim Noble (Assez de mensonges et de phrases)
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To: ChicagoConservative27

I am still getting over a severe bout with COVID and was prescribed Paxlovid. The stuff is nasty and leaves a horrid taste on your mouth, but I took it...Three pills twice daily for five days. Did it help? I’m still alive. My lovely with the RN did not take it and she and I had silimiar outcomes and length of illness.


27 posted on 02/07/2024 8:27:14 AM PST by devane617 (Discipline Is Reliable, Motivation Is Fleeting..)
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To: V_TWIN

Really? How many die “from” Covid without a co-morbidity?


28 posted on 02/07/2024 8:27:48 AM PST by circlecity
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To: ChicagoConservative27
Beware Pfizer’s New Antiviral COVID Treatment Drug Paxlovid
 
12/30/2021 9:21:43 AM PST · by SeekAndFind · 10 replies
NOQ Report ^ | 12/30/2021 | Dr. Joel S. Hirschhorn
The pro-drug industry mainstream media are insanely positive over the newly FDA-approved Pfizer antiviral COVID treatment pills. The drug, Paxlovid, received an emergency use authorization by FDA for use in patients 12 years old and up who have tested positive for COVID-19 and are at high risk.Now is the time to speak truth about Paxlovid. First, everyone should appreciate that there was very little testing of the short- and long-term safety of this product, exactly what happened with COVID vaccines. Really good testing of a new drug should take many months or even years.Does the public really want to take...
 
 
PAXLOVID and Molnupiravir: Avoid
 
12/23/2021 10:07:18 AM PST · by Qiviut · 35 replies
Steve Kirsch's Newsletter ^ | December 23, 2021 | Steve Kirsch
How good is the FDA at EUA approval for COVID drugs? Well, so far, to be honest, pretty shitty. The first three Covid drugs approved under EUA were Remdesivir, Baricitinib, and Tofacitinib. All were EUA approved for inpatient use (in hospital) only, demonstrate dismal effectiveness and are replete with black box warnings and side effects such as organ failure, blood clots, serious infections and malignancy. PAXLOVID PAXLOVID was recently approved by the FDA without any external meetings or disclosure. There was no opportunity for public input. Essentially all done behind closed doors. Dr. Ryan Cole on the drug’s mechanism of...
 
Pfizer’s COVID Pill Paxlovid Fails In Clinical Trials
 
04/26/2022 4:55:20 PM PDT · by ransomnote · 21 replies
greatgameindia.com ^ | 4/26/2022 | GGI Staff
People who took Pfizer’s COVID pill Paxlovid, reported that following the five-day treatment period, they would begin testing positive for Covid again and it has as a result failed in clinical trials.Paxlovid has been hailed as one of the gold standard Covid treatments in the United States, with President Joe Biden mentioning it at this year’s State of the Union speech.However, some people who took the drug to treat the virus have reported an unusual occurrence.The Pfizer-developed medicine is thought to be highly effective at averting hospitalization or death in people who have already been infected with the virus, but...
 
 
Recipients of Biden-touted Paxlovid report Covid symptoms returning and even testing positive for the virus again after completing course of the drug
 
04/23/2022 9:53:49 PM PDT · by SeekAndFind · 7 replies
Daily Mail ^ | 04/23/2022 | MANSUR SHAHEEN U.S. DEPUTY HEALTH EDITOR
Some recipients of Paxlovid, an antiviral pill developed by Pfizer, are reporting Covid symptoms returning after finishing their course of the drug The drug was touted by President Joe Biden and collectively offered to all Americans at his 2022 State of the Union addressThere are multiple reports of people in the Boston area suddenly feeling sick and testing positive for Covid after the drug initially helped them get over the virusOne expert described it as 'cat and mouse', with the virus being able to return after the drug suppressing it cleared from a person's system Paxlovid has been deemed one...
 
 

 


29 posted on 02/07/2024 8:28:22 AM PST by ransomnote (IN GOD WE TRUST)
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To: Candor7
Market forces are at work.

I am sure you are right! The Ivermectin and Zinc should be MUCH cheaper!

30 posted on 02/07/2024 8:28:33 AM PST by Empire_of_Liberty
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To: ChicagoConservative27

maybe population control (a WEF theme)


31 posted on 02/07/2024 8:29:04 AM PST by elpadre (l stance so far, but looking at her impressive bioo, I believe2 she)
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To: Candor7
The Ivermectin/Zinc Dose will cost you 100 bucks.

Ivermectin only cost me $14 at my local Agway. I only used 1/5th of a dose because the full tube is designed for a 1250 pound horse. Zinc tablets are only pennies, less than $10 retail for a 120 tablet bottle.

Wondering how you came up with $100.

I've used Ivermectin/Zinc twice and Paxlovid once. They worked equally well, but the Paxlovid was covered by my Medicare plan. Go figure.

32 posted on 02/07/2024 8:31:19 AM PST by Vigilanteman (The politicized state destroys aspects of civil society, human kindness and private charity.)
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To: Yo-Yo
Because actual clinical trials clearly demonstrated that Ivermectin was a safer and more effective protease inhibitor than Paxlovid and did not have the potentially risky mutagenic properties of Paxlovid. .

Ivermectin also competitvely binds to the ACE2 receptor and thus blocks the action of the Covid spike proteins to enter cells which Paxlovid does not.

Ivermectin also had anti inflammatory properties that suppressed the cytokine storms that were deadly in advanced covid. Paxlovid is actually inflammatory.

The clinical study recommended that both Paxlovid and Ivermectin should be used “synergistic ally” to improve outcomes.

The improved outcomes presumably being that $10 of Ivermectin tablets cured the Covid infection for the patient and the Paxlovid cured Pfizer cash flow issues at $1000 -2000 for a course of treatment

33 posted on 02/07/2024 8:33:46 AM PST by rdcbn1
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To: ChicagoConservative27
Isn’t it amazing that HCQ, Ivermectin, and Pfizer’s PAXLOVID ($72per pill) all inhibit the same SARS 3CLpro enzyme to inhibit replication?
 
11/12/2021 9:09:51 AM PST · by Mount Athos · 30 replies
twitter ^ | Nov 11th, 2021 | Clarke MD
Weird that two are “snake oil” and the expensive one will get EUA {Emergency Use Authorization by the FDA}

34 posted on 02/07/2024 8:34:02 AM PST by ransomnote (IN GOD WE TRUST)
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To: Empire_of_Liberty

If people would go over the dosage calculations available at this site, and read the proptocols on Ivermectin with Zinc.....they would have all info thay need. There are even sources for Ivermectin supply via mail.

https://covid19criticalcare.com/

Be prepared.Especially if you are elderly or diabetic.


35 posted on 02/07/2024 8:34:25 AM PST by Candor7 (Ask not for whom Trump Trolls,He trolls for thee!),<img src="" width=500</img><a href="">tag</a>)
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To: Candor7

BKMK


36 posted on 02/07/2024 8:35:39 AM PST by sauropod (The obedient always think of themselves as virtuous rather than cowardly.)
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To: circlecity

I didn’t state that right.

I agree with you. People with covid that died from some other cause were counted as dying FROM covid.

That is the falsehood I was referring to.


37 posted on 02/07/2024 8:35:46 AM PST by V_TWIN (America...so great even the people that hate it refuse to leave!)
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To: null and void; ChicagoConservative27; metmom
null and void : "Perhaps the medical "profession" has earned our loss of trust?"

Probably because the CDC already shot themselves in the foot
when they used the term :" Safe and Effective" for the original covid vaxxine.

38 posted on 02/07/2024 8:35:49 AM PST by Tilted Irish Kilt
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To: ChicagoConservative27

btw, Dr. AP is full of shite regarding his claim that Paxlovid drug-drug interactions are no big deal:

https://www.fda.gov/media/155050/download

EUA prescribing PDF has this black box warning:

“• PAXLOVID includes ritonavir, a strong CYP3A inhibitor,
which may lead to greater exposure of certain concomitant
medications, resulting in potentially severe, life threatening, or fatal events. (4, 5.1, 7)

• Prior to prescribing PAXLOVID: 1) Review all medications
taken by the patient to assess potential drug-drug
interactions with a strong CYP3A inhibitor like PAXLOVID
and 2) Determine if concomitant medications require a dose
adjustment, interruption, and/or additional monitoring. (7)

• Consider the benefit of PAXLOVID treatment in reducing
hospitalization and death, and whether the risk of potential
drug-drug interactions for an individual patient can be
appropriately managed. (5.1, 7, 14)”

and then there’s this:

“-———————————————CONTRAINDICATIONS-—————

• History of clinically significant hypersensitivity reactions to the active ingredients (nirmatrelvir or ritonavir) or any other components. (4)

• Co-administration with drugs highly dependent on CYP3A for
clearance and for which elevated concentrations are associated with serious and/or life-threatening reactions. (4, 7.3)

• Co-administration with potent CYP3A inducers where significantly reduced nirmatrelvir or ritonavir plasma concentrations may be associated with the potential for loss of virologic response and possible resistance. “

and then the FDA puts this burden on prescribers:

“You or your designee must report all SERIOUS ADVERSE
EVENTS or MEDICATION ERRORS potentially related to PAXLOVID (1) by submitting FDA Form 3500 online, (2) by downloading this form and then submitting by mail or fax, or (3) contacting the FDA at 1-800-FDA-1088 to request this form. Please also provide a copy of this form to Pfizer Inc. at fax number: 1-866-635-8337. (6.4) “

[since the majority of medications metabolize via the set of CYPA hepatic enzymes, the potential for dangerous and even fatal drug interactions with Paxlovid is enormous ... we elderly are particularly vulnerable to this situation because so many of us have to take multiple medications to stay alive ... folks, even the FDA views Paxlovid as a very dangerous drug ...]


39 posted on 02/07/2024 8:35:55 AM PST by catnipman (A Vote For The Lesser Of Two Evils Still Counts As A Vote For Evil)
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To: Vigilanteman

You are right, but if you go the mail order pharmacey route, its around 100 bucks.

The Amish have this pegged just like you do.


40 posted on 02/07/2024 8:36:32 AM PST by Candor7 (Ask not for whom Trump Trolls,He trolls for thee!),<img src="" width=500</img><a href="">tag</a>)
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