Posted on 02/04/2007 11:45:52 AM PST by anymouse
Her carefully cultured cells were dead and Katherine Schaefer was annoyed, but just a few minutes later, the researcher realized she had stumbled onto a potential new cancer treatment.
Schaefer and colleagues at the University of Rochester Medical Center in New York believe they have discovered a new way to attack tumors that have learned how to evade existing drugs.
Tests in mice suggest the compound helps break down the cell walls of tumors, almost like destroying a tumor cell's "skeleton."
The researchers will test the new compound for safety and hope they can develop it to treat cancers such as colon cancer, esophageal cancer, liver and skin cancers.
"I was using these cancer cells as models of the normal intestine," Schaefer said in a telephone interview.
Normal human cells are difficult to grow and study in the lab, because they tend to die. But cancer cells live much longer and are harder to kill, so scientists often use them.
Schaefer was looking for drugs to treat the inflammation seen in Crohn's disease and ulcerative colitis, both of which cause pain and diarrhea.
She was testing a compound called a PPAR-gamma modulator. It would never normally have been thought of as a cancer drug, or in fact a drug of any kind.
"I made a calculation error and used a lot more than I should have. And my cells died," Schaefer said.
A colleague overheard her complaining. "The co-author on my paper said,' Did I hear you say you killed some cancer?' I said 'Oh', and took a closer look."
They ran several tests and found the compound killed "pretty much every epithelial tumor cell lines we have seen," Schaefer said. Epithelial cells line organs such as the colon, and also make up skin.
It also killed colon tumors in mice without making the mice sick, they reported in the journal International Cancer Research.
The compound works in much the same way as the taxane drugs, including Taxol, which were originally derived from Pacific yew trees.
"It targets part of the cell cytoskeleton called tubulin," Schaefer said. Tubulin is used to build microtubules, which in turn make up the cell's structure.
Destroying it kills the cell, but cancer cells eventually evolve mechanisms to pump out the drugs that do this, a problem called resistance.
"Resistance to anti-tubulin therapies is a huge problem in many cancers. We see this as another way to get to the tubulin," Schaefer said.
The PPAR-gamma compound does this in a different way from the taxanes, which might mean it could overcome the resistance that tumor cells often develop to chemotherapy.
"Most of the drugs like Taxol affect the ability of tubulin to forms into microtubules. This doesn't do that -- it causes the tubulin itself to disappear. We do not know why."
Schaefer's team plans more safety tests in mice. As the compound is already patented, her team will probably have to design something slightly different to be able to patent it as a new drug.
Taxol, developed by U.S. National Cancer Institute researchers and manufactured by Bristol-Myers Squibb in 1993, had annual sales of $1.6 billion at its peak in 2000.
Carolyn
She was testing a compound called a PPAR-gamma modulator. It would never normally have been thought of as a cancer drug, or in fact a drug of any kind.My husband has stage four internal melanoma. We will try anything!!
I'm sorry to learn of your desperation. As Shakespeare put it, "Desperate ills are by desperate measures cured. Or not at all."But as to the issue raised by the article: the article does not say that the compound in question is a controlled substance. It says that it killed cancer cells but did not do readily observable injury to mice. You wouldn't know how much of it it would take to do any good, and you wouldn't know how much of it you could take without doing even worse damage to the patient than doing nothing. And you don't know if the stuff would be beneficial if injected, or if taken orally.
But if it isn't a controlled substance, it might be possible to attempt to buy some of it legally. And frankly, in the absence of extrodinary precautions in its manufacture you would expect the people who produce it to be getting some level of the stuff (however small) into their bodies. It would be interesting to know what quantities it is produced in, and how careful they are about ingesting the stuff.
I am not a doctor, and I don't even play one on TV. Your mileage may vary.
You asked about accidental discoveries.
This website describes a number of innovations that were accidental, e.g., vulcanization of rubber, post-it notes:
http://f.dominodeveloper.net/bsniego/sniegocki2.nsf/htdocs/inventions.htm
They don't mention White-out though. It was developed by a legal secratary who was also an artist. She began using white tempera paint to cover mistakes. She made millions. Her son became one of the Monkees.
Carolyn
Prayers for your husband and you also.
Thank you!
I seem to recall that. The Pharmeceutical company planted huge numbers of seedlings of an endangered yew species, and then the greenies sued to keep them from using the trees.
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