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The Methuselah Gene: Who Wants To Live Forever?
Toogood Reports ^ | February 7, 2002 | Isaiah Flair

Posted on 02/07/2002 6:19:20 AM PST by Starmaker

Question:

Who wants to live forever?

Answer:

A lot of people do.

Recently, scientists found something that may help. It won't grant anyone immortality, but it may begin to unravel some of the many mysteries of aging.

In Iceland, scientists have identified a small, mysterious stretch of DNA, a stretch of DNA with unusual effects. They have named it the Methuselah Gene.

The namesake for the gene was, of course, the Biblical Methuselah. A descendant of Adam and Eves son Seth, he is said to have lived for over nine hundred years. These days, people don't live nearly as long. There is a British woman whose age is authenticated at 113, and there was a French woman who lived for 122 long years.

However, humans living past the century mark are rare. Humans wanting to live that long are quite common, thus the excitement over the Methuselah gene.

It is being researched right now by the Icelandic biotechnology firm, DeCode Genetics. The firm´s CEO, Kari Stefansson, spoke about exploring the gene´s potential.

“There is no reason why we cannot do this,” said Stefansson, “We know the location of this gene. Soon we will study its exact DNA sequence and work out how it works in the body. You can then think of making drugs that could replicate its action.”

The gene was found by company researchers who traced birth and death records in Iceland. These records are unique, and trace back to the era of Viking eminence in that corner of the world. They allowed researchers to compare and contract Icelandic citizens who had lived for nine decades or longer.

A possibility was advanced: would 1200 Icelanders with an unusually long life span have something genetically in common with one another? Something which was not shared with a “control” group of 1200 shorter-lived Icelanders with comparable lifestyles?

The possibility was advanced. It had two subordinate postulates: the long-lived group might lack genes which predisposed others to potentially life-shortening medical conditions...or they might have a single gene which, for reasons which have as yet only been speculated on, extended the life of those lucky enough to have it.

DeCode researchers began their search for interesting genes in the genetic material of long-lived Icelanders.

“We simply did not know, until we studied our markers, and to our surprise found that old age behaved as if it was being conferred by a simple, single gene,” said DeCode CEO Stefansson. “Somehow this gene is making a protein in the body that is helping people live to ripe old ages.”

They had wondered if this could be possible. They had speculated on the possibility of such a gene. Now, they have found it.

What next? Are there other genes, more potent still then Methuselah? What mysteries in the DNA code have yet to be unraveled? And what do they have to offer to the future of humanity?

Someone, a long time ago, wrote something very complex and beautiful in genetic letters.

Slowly, one letter by one letter, we are beginning to read it. We could spend our lives, perhaps, reading it with out ever expending it all. Then again, that depends on how long are lives on Earth turn out to be.

Who wants to live forever? After all these years, it´s still an interesting question.


TOPICS: Culture/Society; Editorial
KEYWORDS: crevolist
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1 posted on 02/07/2002 6:19:20 AM PST by Starmaker
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Comment #2 Removed by Moderator

To: IceCreamSocialist
Methusula's 900 years is about the staistical limit for something other than old age getting you. And eternity is long, even compared to 900 years.
3 posted on 02/07/2002 7:04:17 AM PST by eno_
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To: eno_
I wonder if Methusula looked like Yoda when he finally died.
4 posted on 02/07/2002 7:09:22 AM PST by krb
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To: eno_
Methusula's 900 years is about the staistical limit for something other than old age getting you.

Like most people, I wouldn't mind taking my chances ;)

OTOH, I keep picturing those things from "Gulliver's Travels" - the people that lived forever, but continued aging nonetheless, such that living forever was much worse than death. IMO, what most people want is not to live forever, but to be young forever...

5 posted on 02/07/2002 7:23:54 AM PST by general_re
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To: Starmaker;realwoman;texas gal;wwjdn;harrison bergeron;spookbrat;xm177e2;carenot;utah girl;argee...
P I N G !!!
6 posted on 02/07/2002 10:00:08 AM PST by The Good Hunter
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To: krb
I wonder if Methusula looked like Yoda when he finally died

It has been written that he looked like Helen Thomas.

7 posted on 02/07/2002 10:04:26 AM PST by Inspectorette
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To: IceCreamSocialist
If you're of a more secular nature and go for all that Theory of Evolution stuff, wouldn't living forever slow or halt the progress of the human species as a whole? Isn't it your duty to the species to die and make room for the following generations?

On the premises of survival of the fittest, hell no! Let the other moral idiot die for future generations...you can spread a whole lotta seed in 900 years.

8 posted on 02/07/2002 10:07:20 AM PST by Pistias
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To: Inspectorette
It has been written that he looked like Helen Thomas.

But without the pleasant personality/senility exhibited by Thomas. :-)

9 posted on 02/07/2002 10:11:41 AM PST by Young Rhino
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To: The Good Hunter
Of course I want to live forever. But not in this body. Catch my drift?
10 posted on 02/07/2002 10:47:48 AM PST by rdb3
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To: The Good Hunter
A wise old priest had a favorite little "curse,"

May you live forever.

I do not want to live forever, W.

11 posted on 02/07/2002 11:23:04 AM PST by Brian Kopp DPM
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To: IceCreamSocialist
Not forever, but it would be cool not to be sick for the last 30 years of life.

I come from a line line of folks who are basically healthy to age 90. My parents are both mid-90s and are starting to decline, but they are not in nursing homes.

Living to 90 or more without having cancer or heart disease is realistic and desirable.

12 posted on 02/07/2002 11:28:25 AM PST by js1138
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To: The Good Hunter
The Methuselah Gene: Who Wants To Live Forever?

Not me.

To live is Christ, to die is gain.

Shalom.

13 posted on 02/07/2002 11:59:13 AM PST by ArGee
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To: Starmaker
Someone, a long time ago, wrote something very complex and beautiful in genetic letters.

Heh, heh, heh.
14 posted on 02/07/2002 12:01:13 PM PST by aruanan
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Comment #15 Removed by Moderator

To: Pinlighter
In fact, even if our health was guaranteed, we probably would not dare do anything even slightly dangerous, because that would loose us millions of years of life. Think about it. No flying, driving, not even daring to cross the road.

Lockean society is set along the lines of cowards, and science services Lockean societies.

16 posted on 02/07/2002 12:09:50 PM PST by Pistias
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To: IceCreamSocialist
Even with no chance of dying of old age, an equilibrium will be reached. Accidents and that inevitably fatal disease: natural causes, get to everyone. (Natural causes cannot be diagnosed. You never hear someone say: "He's got a bad case of natural causes.") The result is equivalent to just adding a bunch of people now.
17 posted on 02/07/2002 12:10:57 PM PST by Doctor Stochastic
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To: Starmaker
When they find a way to stop telomere decay then we'll talk. I don't want to live forevere and its impossible even if you can stop aging eventually you will be killed.
18 posted on 02/07/2002 4:28:53 PM PST by weikel
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To: The Good Hunter
"Someone, a long time ago, wrote something very complex and beautiful in genetic letters."

My favorite sentence in this piece.

I don't think I would want to live forever. If we knew we had forever, we would put off living. As long as we have no guarantee of tomorrow or next year, it helps motivate us to life a joyful life and take care of business. I figure I'll die at 74, give or take a few years. (everyone else in my family dies at that age). That means I have 41 more years to make the best of things, live right, travel and love as many people as possible.

Thanks for the ping.

19 posted on 02/07/2002 5:27:25 PM PST by SpookBrat
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To: Pinlighter
Yeah, the fact is if we lived for ever we would have a very different lifestyle from the one we have now. In fact, even if our health was guaranteed, we probably would not dare do anything even slightly dangerous, because that would loose us millions of years of life. Think about it. No flying, driving, not even daring to cross the road.

I've wondered about that, but remember: Our lives today are much longer than those of average Americans of 100 years ago. Everyone's grandparents can tell (could have told) you about more than one sibling or friend who died at an early age from some disease or genetic malady that just isn't a problem today.

I know extreme safety is a faddish value in our society today, but I think it's more because Baby Boomers haven't really known privation or hardship like our Depression/WWII parents & grandparents did. If the War on Terrorism became WWIII, we could see the Generation Z grow up with quite different attitudes towards death than Boomers. "Using up one's life well" as opposed to "extending one's life at all costs", in a way.

20 posted on 02/08/2002 3:03:14 PM PST by jennyp
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