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Ivermectin: Could Population-Wide Distribution Have Prevented China's Recent Mass COVID Outbreak? Consider the Experiences of India and Peru
Epoch Times ^ | 01/31/2023 | Dr. Sean Lin and Mingjia Jacky Guan

Posted on 01/31/2023 9:15:31 PM PST by SeekAndFind

China’s state-run medicare program recently failed to reach an agreement with Pfizer to import more Paxlovid, claiming the COVID-19 treatment drug is too expensive. This is despite the drug being offered to the state at a reduced rate in comparison with that offered to other developed countries. Lack of Paxlovid will leave only Azvudine, an anti-HIV drug the Chinese communist regime rushed through development and re-branded as an anti-COVID drug, as a treatment option.


An ivermectin bottle next to a positive blood sample of COVID-19. (Novikov Aleksey/Shutterstock)

Given the recent explosive spread of COVID and the resulting skyrocketing rates of hospitalization, finding viable treatment options is paramount.

Ivermectin in India and Peru

When the Delta variant broke out in 2021 across India, many states offered ivermectin population-wide. The efficacy of ivermectin in treating early and mild COVID-19 infections was confirmed in large states such as Uttar Pradesh—home to 241 million residents—where the use of the prophylactic dramatically reduced both the infection rate and the death toll.


Data from a study comparing the efficacy of ivermectin in frontline health care workers. (The Epoch Times)

Even among frontline health care workers, ivermectin proved to be an effective prophylactic against COVID-19. One study with 3,532 frontline health care workers from the All India Institute of Medical Sciences Bhubaneswar found that two doses of oral ivermectin (300 μg/kg given 72 hours apart) as chemoprophylaxis among health care workers reduced the risk of COVID-19 infection by 83 percent in the following month.

In Peru, mass ivermectin treatments were conducted through a broad-scale effort called Mega-Operación Tayta, or MOT for short. Operation MOT was led by the Peruvian army and involved 10 states, where the excess death rate saw a sharp decline with an average of 74 percent over 30 days. In 14 states where ivermectin was administered locally, the mean reduction in excess deaths over 30 days compared with deaths was 53 percent.

Lima, the capital of Peru, where the distribution of ivermectin was restricted, saw only a 25 percent reduction in excess deaths. The findings of researchers, detailed in the diagram below, show infection numbers, deaths, and fatalities across Peruvian states which implemented ivermectin (blue) and those which did not (red). The conclusion is that a reduction in deaths correlated with the distribution of ivermectin with a statistically significant p-value of less than 0.002.


COVID-19 data from Peru’s 2021 Delta outbreak comparing states that dispensed ivermectin (green) and those that did not (blue). (The Epoch Times)

Ivermectin–The Wonder Drug

Ivermectin was discovered in Japan during the late 70s as a derivative of Avermectin, produced from a single organism isolated at the Kitasato Institute in Tokyo. Since then, ivermectin has played an immeasurable role in improving the lives of billions with its humble beginnings as an anti-parasitic drug.

Ivermectin, approved by the U.S. Food and Drug Administration and deployed worldwide since 1987, has made major inroads against two devastating tropical diseases—onchocerciasis and lymphatic filariasis. In addition, some topical forms of ivermectin are approved to treat external parasites like head lice and skin conditions such as rosacea.


Ivermectin is potentially effective against a host of viruses. (The Epoch Times)

In addition to its anti-parasitic effects, a 2022 study published in the European Journal of Medicinal Chemistry Reports found that ivermectin has a strong potency at low concentrations against many DNA and RNA viruses, including HIV-1, yellow fever, malaria, West Nile virus, Zika, dengue fever, etc.

According to the study, ivermectin has an amazing inhibitory effect across multiple species and can interrupt motility and reproduction in both arthropods (such as insects) and nematodes (such as roundworms). This explains why ivermectin is prescribed for parasite infections, and also sheds light on its potential as a prophylactic against vector-borne diseases. In insects and other arthropods specifically, it can interrupt the transmission of disease.

Ivermectin’s Potential Mechanisms Against COVID

SARS-CoV-2 is a virus that takes over host cells to multiply in the body. To enter the host cells, the virus binds to the ACE-2 receptor on the surface of cells which grants them entry. Ivermectin prevents the bonding process by interfering with the virus’s spike proteins—this is the same mechanism the vaccines use.

If the virus slips past the cell membrane, its top priority is to infiltrate the brain of the cell—the DNA-containing nucleus—to start mass-producing itself. SARS-CoV-2 latches itself onto a special class of transport proteins called IMPs that have enough security clearance to enter the nucleus. In the case of a viral infection, ivermectin binds to these transport proteins and halts the interaction.


Ivermectin inhibiting intracellular transport and viral production. (The Epoch Times)

Ivermectin also inhibits the nuclear transport mechanism mediated by the KPNA-1 protein, which has a similar effect when compared with IMPs. Both proteins can enter the nucleus and ivermectin can effectively stop the virus from getting to the nucleus. In the event that the virus does manage to invade the nucleus—ivermectin also has a backup plan.

For example, when the virus has taken over and initialized self-replication, it does so through a protein called RdRp, which is at the centerpiece of viral replication—and is directly inhibited by ivermectin with very high efficacy.

Ivermectin Could Reduce Severe Lung Damage in COVID Patients

Once COVID-19 reaches later stages, it may require intensive care for recovery. For example, white lung syndrome (a hallmark symptom of acute respiratory distress syndrome) now occurring in severe COVID infections in China, is a sign that the virus has deeply infected the lungs and may have caused cytokine storms (a severe immune reaction in the body) in patients.

Other complications that arise from COVID-19 involving the lungs are conditions such as pulmonary fibrosis and hypoxia. Hypoxia occurs when the virus infects lung tissue to the extent that the alveoli, tiny sacs of air at the end of lung branches responsible for oxygen exchange, become scarred causing a severe loss of oxygen in the body.

Cytokines and chemokines are responsible for inflammation, a natural immune system response to foreign invaders. However, a large number of cytokines released into the body all at once can cause a “cytokine storm,” wherein the body is flooded with armies of white blood cells that harm the body.

A cytokine storm can be triggered through the TLR-4 pathway by the virus. The same pathway also triggers the release of nitric oxide, causing fluid leaks, dilating blood vessels, or even sepsis and fluid buildup in the lungs.

Read more here...


TOPICS: Culture/Society; Foreign Affairs; News/Current Events
KEYWORDS: china; conspiracysite; covid; doesthiseverstop; dumbingdownfr; garbagesource; itdoesntwork; ivermectards; ivermectin; ivermectinismagical; notthisagain; outbreak
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1 posted on 01/31/2023 9:15:31 PM PST by SeekAndFind
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To: SeekAndFind

They could have saved the lives of all the horses in China. LOL


2 posted on 01/31/2023 9:20:08 PM PST by reg45 (Barack 0bama: Gone but not forgiven.)
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To: SeekAndFind

Hydroxychloroquine may have been helpful. Any numbers out of Africa on CONvid?


3 posted on 01/31/2023 9:22:36 PM PST by rktman (Destroy America from within? Check! WTH? Enlisted USN 1967 to end up with this? 😕)
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To: SeekAndFind

Nothing in the article about zinc being part of treatment. Ivermectin was to help the body absorb the zinc - when this became less available due to the rush on ivermectin, there were articles about using quercetin as an alternative to the ivermectin.

So this is inconsistent with other articles about how helpful ivermectin was said to be in treatment.


4 posted on 01/31/2023 9:46:49 PM PST by Republican Wildcat
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To: Republican Wildcat

With all due respect you are thinking of hydroxychloroquin (sp?) or HCQ. That is a zinc ionophore.

IVM has a different mechanism of action.

FWIW - there are good studies that show that quercetin (a nutritional supplement) is also a pretty effective zinc ionophore if HCQ is not available.


5 posted on 01/31/2023 9:59:09 PM PST by volunbeer (We are living 2nd Thessalonians)
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To: SeekAndFind

Herr Doktor Phauceee would never have allowed such a scandalous publication.


6 posted on 01/31/2023 10:04:20 PM PST by budj (Combat vet, second of three generations.)
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To: volunbeer

You are correct. The mechanism of ivermectin is believed to be that as a protease inhibitor, it helps keep the spike protein from entering cells.

Some protocols recommend combining the zinc/ionophores alongside ivermectin if not seeing success from one alone. My GP is using both to treat post-vaccine patients. She says the results are remarkable.


7 posted on 01/31/2023 10:13:47 PM PST by LilFarmer
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To: SeekAndFind

Ivermectin is a miracle drug against viruses.


8 posted on 01/31/2023 10:22:33 PM PST by nagant
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To: SeekAndFind

In President Trump’s recent speech outline his proposed program for dealing with ‘transgendering’ children, he said the hormone therapies used on these children were never licensed or authorized for their use for this purpose. I immediately thought back to Ivermectin and HCQ, both of which had an excellent safety record for decades but were banned because they were not specifically ‘authorized or licensed’ for Covid-19.

People died because of the politicization of medication; it’s like the CDC/FDA ‘gets’ to decide what the definition of ‘is’ is.

I just watched a few video presentations about hormone therapy for kids and was stunned at the lasting medical damage done to children with transgendering hormones. Truly medical malpractice. They don’t even tell the girls that after 5 years of testosterone, they may require a hysterectomy because the uterus can become infected as it atrophies! There’s no followup - they are given health and development altering drugs and sent out the door.

If you are seriously ill (Covid) in an emergency situation and there are no alternatives, you can’t have Ivermectin or HCQ, even if it’s a last ditch effort. But if you are a healthy child and it’s not an emergency, you can have, without your parents consent, drugs that will permanently damage your health (sterility, autoimmune issues, endocrine and cognitive development issues and later surgeries etc.)


9 posted on 01/31/2023 11:23:47 PM PST by ransomnote (IN GOD WE TRUST)
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To: nagant

and some bacteria, like SEB which is on the spike protein.

SEB also causes food poisoning, Ivermectin seems to cure that quick


10 posted on 01/31/2023 11:51:59 PM PST by TeleStraightShooter (Omicron could be the Live Attenuated Vaccine in project DEFUSE, which was rejected by DARPA)
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To: SeekAndFind

The short answer? Yes. The complete answer...makes me to angry to even start to type it.


11 posted on 02/01/2023 1:30:35 AM PST by know.your.why (Be not eager to be offended. The narcissism of small differences leads to THE most boring conformity)
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To: SeekAndFind

12 posted on 02/01/2023 1:37:31 AM PST by know.your.why (Be not eager to be offended. The narcissism of small differences leads to THE most boring conformity)
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To: SeekAndFind

Simple answer is YES!


13 posted on 02/01/2023 2:24:29 AM PST by spincaster
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To: Republican Wildcat

👍


14 posted on 02/01/2023 3:25:48 AM PST by griswold3 (Truth, Beauty and Goodness )
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To: SeekAndFind

Here’s a list of sources for IVM, HCQ, the associated antibiotics, and all regular meds. No Rx required, ships from India, takes about 21 days. (Ivermectin.com ships from the US and arrives faster, but costs more.) I’ve done test orders from all of them except Grant Pharmacy and Ivermectin.com.


REYNOLD MEDS [This is the source my friends and I prefer; for IVM and regular meds. The owner’s name is Reynold Brooke. He also sells some brands of baby formula. His prices are competetive, excellent customer service, and he loves America and Trump.]

If what you need isn’t listed, email him directly.

https://reynoldmeds.com

renold2876@gmail.com


Grant Pharmacy

https://www.grantpharmacy.com


BuyIVERMECTIN24

https://buyivermectin24.com

[Note: This place is good, but they telespammed me for a couple of months after my orders so I stopped using them.]


SafeGenericPharmacy

https://www.safegenericpharmacy.com


AllDayChemist

https://www.alldaychemist.com


IVERMECTIN.COM

https://ivermectin.com

sales@ivermectin.com

Ships from US, so no customs worries and faster delivery time. Ivermectin only. Much higher prices than overseas.



15 posted on 02/01/2023 5:11:09 AM PST by Non-Compliant_Deplorable
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To: spincaster

The question assumes that there was indeed an outbreak of SARS-CoV-2.

Given what we have learned over the last three years, I wouldn’t make that assumption.


16 posted on 02/01/2023 5:15:10 AM PST by mewzilla (We will never restore the republic if we don't first secure the ballot box.)
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To: mewzilla; nickcarraway; ransomnote; Jane Long; DoodleBob
And since India is mentioned, a case in point ,so to speak, related to my above reply, from last year...

Prevalence of Malaria and Covid-19 in Febrile Patients in Lomé, Togo in 2020

...This study confirms a possible cross-reactivity between Covid-19 and malaria in case of single use of rapid tests, suggesting a possible past contamination. In case of clinical signs related to Covid-19 in malaria-endemic areas, PCR screening should be requested in order to identify and isolate patients.

If cross-reactivity is an issue, and if so, I'm betting not just with PCR tests, then case stats really are crap, aren't they...

17 posted on 02/01/2023 5:22:16 AM PST by mewzilla (We will never restore the republic if we don't first secure the ballot box.)
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To: SeekAndFind

The Han Chinese supposedly have very high IQ. They should have showered their population with free D3. After all, they manufacture most of the D3 sold here.


18 posted on 02/01/2023 5:30:14 AM PST by dennisw ("You don't have to like it. You just have to do it")
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To: SeekAndFind

Lots and lots and lots of videos out of China revealed that the general treatment for Covid ptients was a saline drip IV.

The ubiquitous saline drips were present not only within but outside hospitals clogged with patients. The situation got so bad that they ran out of the IV stands. To remedy the proplem, cables were strung between lamp poles along the sidewalks from which the IV bags could be hung. At lest one enterprising hospital out of space and beds developed a rig to support the IV bag for the patient within their cars. They developed Drive-In Saline IV’s

The total numbers are efffectively uncollectable but the estimate is 900 million cases in the time since the lockdown was curtailed. The number of deaths totally wiped out the ability to cremate or otherwise deal with the corpses. There are scenes of seemingly endless stacks of corpse filled orange or yellow body bags.

If there is recovery, China will never be thee same


19 posted on 02/01/2023 5:32:21 AM PST by bert ( (KWE. NP. N.C. +12) Juneteenth is inequality day )
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To: SeekAndFind

My doctor prescribed Ivermectin a few months ago to help with a skin condition. Of course, my stupid insurance company refused to cover the script and sent me a sanctimonious letter all about the dangers of Ivermecting for covid. They are too stupid to read that it wasn’t for covid. (I did bootleg some and along with Querecedin and other stuff it worked extremely well when I did have covid)

The medical establishment is completely broken and untrustworthy.


20 posted on 02/01/2023 5:46:01 AM PST by cyclotic (Follow 1776rm.com. Fighting for our Constitution. @1776RM on Truth)
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