Posted on 05/06/2022 9:42:13 AM PDT by House Atreides
It sounds like something that might have come out of a sci-fi novel, but it's based on cold, hard, printed research: transplanting fecal microbes from young mice into old mice seems to reverse key signs of aging in the guts, eyes, and brains of the older animals.
Further experiments showed that it works the other way too – moving microbes from the poop of aged mice into younger mice caused the younger animals to then show signs of aging, including increased inflammation in the brain and a reduction in a key protein needed for normal vision.
It's by no means a recipe for eternal youth, but as we get older we naturally become more susceptible to wear, tear, and disease – in part due to the way our guts degrade. These experiments show that something could be done about that, although only mice guts have been tested so far.
"Here, we tested the hypothesis that manipulating the intestinal microbiota influences the development of major comorbidities associated with aging and, in particular, inflammation affecting the brain and retina," write the researchers in their published paper.
Increased inflammation around the brain and the retinas in the eyes tends to happen as we get older, while age-related chronic inflammation – called 'inflammaging' – has been linked to specific immune cells.
When the poo microbes were transferred from young to old mice, this inflammation showed signs of reversing. When the transplant was moved the other way, signs of gut aging and inflammation began to appear in the younger mice.
These signs included a loss of integrity in the gut lining (so bacteria could pass into the blood), elevated levels of proteins associated with retinal degeneration, and the over-activation of the immune cells that are tied to inflammaging.
"Our results demonstrate that the age-associated changes in the murine intestinal microbiota contribute to disrupted gut barrier integrity and systemic and tissue inflammation affecting the retina and the brain, but these changes can be reversed by replacement with young donor microbiota," write the researchers.
Scientific studies are giving us more and more of an understanding about all the different ways that our gut microbes are linked to our health – whether that's mental health issues such as anxiety or physical health issues like obesity.
In other words, the mix of bacteria in our bellies really matters, and changing that mix – whether through diet or fecal transplants – has the potential to bring about a variety of different health benefits.
Now there's another option worth exploring for researchers. Future studies are planned to look at how long the positive impacts of these fecal transplants might last for, and which gut microbes in particular are controlling the effects that are being seen. Then, scientists can start to explore whether it could work in humans too.
"This ground-breaking study provides tantalizing evidence for the direct involvement of gut microbes in aging and the functional decline of brain function and vision and offers a potential solution in the form of gut microbe replacement therapy," says gut biologist Simon Carding, from the University of East Anglia in the UK.
The research has been published in Microbiome.
Eat Popcorn. FDA allowed contaminate:
Popcorn: 1 or more rodent excreta pellets [i.e., mouse poop] are found in 1 or more subsamples, and 1 or more rodent hairs are found in 2 or more other subsamples OR 2 or more rodent hairs per pound and rodent hair is found in 50% or more of the subsamples OR 20 or more gnawed grains per pound and rodent hair is found in 50% or more of the subsamples
OK. I went along with the calorie restricted diet, but this is going too far.
Burma Shave.😁
So living on the ground floor of a two-storey outhouse is a GOOD thing???
You sh1ttin me?
The Elites will no longer drink the blood of children...
Great, immortal mice. Just what the world needed.
If I gotta eat $hit to live then I don’t wanna live...
If this was true, faggots would have long life spans.
HOLY $#!+
Ah, those experiments designed by homosexual human males worried about the detrimental effects of their behaviors!
Yo, Ma, where d’mouse poop at?
So that’s how all those gay guys stay so young looking!
Not if it’s going from old mice to young mice. Then it seems accurate, per the report.
I ought to live forever because the government has been feeding me sh#t my whole life.
Nothing graceful about getting old believe me. Unless I grab a grocery basket or hang on to my wife, I look like a drunk trying to get into a store.
You realize that mouse turds and wheat grains are very near the same size right? The Ag department allows a certain amount of turds and bugs in flour because it is unavoidable. We live in a world of bugs seen and unseen get over it and develop immunity from most of them by not living in a sterile environment. I have had a fever once in 40 years until last week. I had a small stroke and spent a night in hospital, came home and second day back had a fever for most if afternoon on second day home, took some horse pills and got over by late afternoon.
I think in previous studies, poo from a fat specimen was inserted into a thin specimen. Sure enough, the thin one got fat. So they did it the other way, and the fat one got thin.
Weird stuff happening down there!
Hooo-boy! The you-know-who crowd is gonna be ALL OVER this one. Won’t be long and “Consumer Reports” will publish their “New Poo Review” about who’s got the best @#%t and where to get it.
The world’s gone stark raving mad.
All you need is a needy teenager and a shoe horn?
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