EVMS Protocol
Posted on 10/23/2020 5:56:46 PM PDT by catnipman
Convalescent plasma generated great enthusiasm in the earliest days of the coronavirus disease
The PLACID Trial was a rigorous randomized controlled study on a topic of enormous global importance
In prespecified, intention-to-treat analyses, the PLACID Trial investigators found no net benefit associated with convalescent plasma in patients admitted to hospital with moderate covid-19
there was no net clinical benefit to patients
(Excerpt) Read more at bmj.com ...
Wow. This thing is really a super virus. I wonder how that happened? /s
Consider the source...
Trust but verify.
The convalescent plasma made available for patients in May under an EUA was not titered - some units had a lot of antibody, some had little.
It was a good idea, but there is no way to make sense out of this “trial” since we do not know who got what in terms of neutralizing antibody.
I’d take it!
The convalesvent plasma reduced viral load — no question about that — but the prothrombotic potential is messing up the receiving patients.
I don’t think this means that plasma with covid antibodies won’t help you recover from covid, but it may still make you immune.
They cared nothing for the lives of patients, but cared everything for winning political favor and rewards.
As opposed to plasma, which has the platelets filtered out.
I am not a doctor, and really don't know what's customary here. I heard that using donated antibodies has had some success, was that wrong?
Hmmm... Like you, I wonder.
MAYBE — just maybe - when Fauci invented the virus he made sure it only could be treated by the vaccine he invented. Just throwing out a possibility!
I was hoping that Trump would offer some of his plasma to Joe at the debate if he wasn’t feeling too perky.
The big criticism of the study is that it was used too late in the disease. An earlier study that used it sooner showed some help. Nothing dramatic.
“I don’t believe a damn thing “medical journals” “
MATH+ therapy 100% effective
https://www.hsgac.senate.gov/covid-19-how-new-information-should-drive-policy
Starting about minute 48, MATH+ therapy described. 98% effective for serious cases. Known since April. No new drugs or vaccines are needed. Cv19 is easily treated.
I thought there were extremely few confirmed cases of a “cured” patient subsequently getting re-infected. Like a handful of confirmed cases.
What the paper concluded was that convalescent plasma worked in producing neutralizing antibodies that reduced the SARS-COV-2 viral load but both arms of the study had about the same mortality and other adverse effects. This was because other proteins in the human plasma caused blood clotting and cardiac events that led to negative outcomes.
This would not occur in monoclonal antibody therapies like Regeneron that are manufactured and do not contain all the other proteins in natural human plasma.
Convalescent plasma was considered an attractive therapy because it could be easily produced and would be available without FDA approval. It would probably work if patients were also given anticoagulents like Xarelto or Eliquis to reduce the coagulation risk but it would be better to use Regeneron’s drug which has no coagulation risk.
I believe Fauci supported this 100%. I’ll google around.
Man oh man, wouldn't THAT have been one for the ages? I can just see Dementia Joe's face now. :-)
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