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How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes
Science Magazine ^ | Apr. 17, 2020 , 6:45 P | By Meredith Wadman, Jennifer Couzin-Frankel, Jocelyn Kaiser, Catherine Matacic

Posted on 04/17/2020 7:29:29 PM PDT by Lazamataz

On rounds in a 20-bed intensive care unit (ICU) one recent day, physician Joshua Denson assessed two patients with seizures, many respiratory failure and others whose kidneys were on a dangerous downhill slide. Days earlier, his rounds had been interrupted as his team tried, and failed, to resuscitate a young woman whose heart had stopped. All shared one thing, says Denson, a pulmonary and critical care physician at Tulane University. “They are all COVID positive.”

As the number of confirmed cases of COVID-19 surges past 2.2 million globally and deaths surpass 150,000, clinicians and pathologists are struggling to understand the damage wrought by the coronavirus as it tears through the body. They are realizing that although the lungs are ground zero, its reach can extend to many organs including the heart and blood vessels, kidneys, gut, and brain.

“[The disease] can attack almost anything in the body with devastating consequences,” says cardiologist Harlan Krumholz, “Its ferocity is breathtaking and humbling.”

Understanding the rampage could help the doctors on the front lines treat the fraction of infected people who become desperately and sometimes mysteriously ill. Does a dangerous, newly observed tendency to blood clotting transform some mild cases into life-threatening emergencies? Is an overzealous immune response behind the worst cases, suggesting treatment with immune-suppressing drugs could help? What explains the startlingly low blood oxygen that some physicians are reporting in patients who nonetheless are not gasping for breath? ...

What follows is a snapshot of the fast-evolving understanding of how the virus attacks cells around the body, especially in the roughly 5% of patients who become critically ill. Despite the more than 1000 papers now spilling into journals and onto preprint servers every week, a clear picture is elusive, as the virus acts like no microbe humanity has ever seen. ....

(Excerpt) Read more at sciencemag.org ...


TOPICS: News/Current Events
KEYWORDS: bioweapon; chatforum; cv19; horror; timeline
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To: NEBO

I am sorry she was widowed recently.

I am glad she is liking her new home very much.

Sooner than later I hope the lockdown ends and she goes back to enjoying herself :)

It’s a different world.

I read about someone dying in their 70s and i think they died young.

100 will become much more common going forward. At least among the 80 and 90 something crowd now.

They ate healthy in their youth and usually retained those eating habits.

Today’s generation doesn’t eat nearly as healthy in too many cases


81 posted on 04/17/2020 9:55:43 PM PDT by dp0622 (Radicals, racists dont point fingers at me I'm a small town white boy Just tryin to make ends meet)
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To: SoCal Pubbie; Lazamataz

Spanish flu deaths,,,?
.
Could you share
Some highlights?


82 posted on 04/17/2020 9:57:39 PM PDT by Big Red Badger (He Hath Not Given Us A Spirit Of Fear)
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To: Lazamataz

C19 bump for later...


83 posted on 04/17/2020 9:58:51 PM PDT by indthkr
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To: Lazamataz
This is NOT influenza.

11 people on the fire department that I retired from tested positive two weeks ago. 1 developed symptoms that he thought were from seasonal allergies. None of the others developed any symptoms. They all tested negative yesterday. If they were not firefighters none of these guys would have been able to get a test.

No, its not the flu...

84 posted on 04/17/2020 10:11:37 PM PDT by fireman15
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To: Lazamataz
This virus is weird. Lots of people, it barely touches, but for those that get hit hard, it behaves so oddly.

I was a Hazmat officer for many years. This virus acts similar to some types of Hazmat exposures. If your first encounter with it gives you only a light viral load and you have a healthy immune system your body will fight it off and develop antibodies with you never developing any symptoms.

If your first exposure is in an enclosed space with a bunch of coughing people spewing out a large amount of viral particles you may have an extreme reaction even with a healthy immune system. Lesson learned... do not get into an elevator with a bunch of sick people.

85 posted on 04/17/2020 10:19:35 PM PDT by fireman15
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To: Lazamataz

Great post!


86 posted on 04/17/2020 10:20:41 PM PDT by <1/1,000,000th%
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To: chuckb87; Vermont Lt; Ozark Tom; Lazamataz; fwdude; dp0622; null and void
Then how come a good number of people who contract it have relatively mild or NO reactive symptoms? Something doesn’t jive.

Maybe that's the point.

Recall after 9/11, we had the anthrax attack. It was weaponized/aerosilized anthrax- this wasn't just some wacko sending ricin through the mail. This guy (ok...I'll be inclusive) or gal knew what they were doing.

And yet...that terrorist didn't go all-in. They sent just a few letters, registered only a handful of murders and a few hospitalized people....and scores of closed Postal facilities, and millions of terrified Americans who - wait for it - altered their behavior because a highly-remote chance of death was sitting in the day's mail.

I was in the NYC area at that time and I recall friends and family outside the NYC area saying basically that it was stupid to open mail outside with a mask on, that the chance of weaponized anthrax being in MY mail was remote and the mask wouldn't help me anyway blah blah blah. Perhaps....but they weren't living in MY neighborhood, they didn't have to commute to work and see NO Twin Towers EVERY DAY, and if they would kindly STFU that would be grand.

Per this article, this contagious, easily-transferred but 96% non-lethal bioweapon simply isn't easy to pigeonhole. If someone wanted to further tear apart a nation of Patriots and loyalists, and cripple their economy without wiping everyone out, this seems like a perfect way to go about that plan. The only problem may have been that the planned cracking open of the vial happened in town vs Times Square.

87 posted on 04/17/2020 10:22:25 PM PDT by DoodleBob (Gravity's waiting period is about 9.8 m/s^2)
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To: ProtectOurFreedom

There is a person here with a scientific background that continues to deflect from the chapel hill sars/horseshoe bat study..even to the point of yesterday posting a completely different study to pretend the chapel hill study wasnt about a Sars version of a virus..

Of course we now realise the chapel hill study involved the Wuhan bat lady that is now nowhere to be found

I find this deflection to be really odd. Even the media is now admitting it could have come from a lab..even if it was not man made

Not sure if that poster is connected to the study..chapel hill..or china.

Wuhan bat lady could have taken chapel hill study and recreated in wuhan.

A military general who is a bioweapons expert took over the wuhan lab in feb. Chen wei.


88 posted on 04/17/2020 10:40:27 PM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
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To: RummyChick

Btw..the name of possible patient zero has been released. Various media have reported the name. China denies it. Person has been scrubbed from website as per forbes.

Bat lady swore it didnt come from her lab
Back in feb.

Bat lady ..who could help to get to bottom of all of this..including finding a cure..is nowhere to be found.


89 posted on 04/17/2020 11:07:05 PM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
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To: Lazamataz

ping


90 posted on 04/17/2020 11:31:41 PM PDT by happytrumper
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To: Lazamataz

Bookmark


91 posted on 04/17/2020 11:33:25 PM PDT by aquila48
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To: RummyChick
You mean like this one that someone decided to add notes to in order to deflect?

Engineered bat virus stirs debate over risky research

Why go out of the way to add notes on all these old pages that have been dug up? We stopped the funding and Dr. Shi Zhengli took her experiment to China. So what's the problem and why do we lie like the CCP?

92 posted on 04/17/2020 11:41:19 PM PDT by Ymani Cricket (Pressure makes diamonds - General Patton)
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To: ProtectOurFreedom
This was explained on MedCram and other medical sources two or three weeks ago. It attacks your hemoglobin cells and attaches to the hemoglobin receptors that normally transport oxygen.

Bingo! I read those reports a couple weeks ago. It's not the lungs, it's the hemoglobin's ability (or lack of) to grab oxygen. How can so many other scientists and medical "experts" be so wrong in the attached article on this thread? Sars-CoV-2 strips away iron ions in hemoglobin cells, so they can't absorb oxygen let alone transport it to organs throughout the body. The lungs are tossing oxygen, but the blood won't receive! Failed passes. So the liver starves, the kidneys starve, the brain starves, every part of the body is starving for oxygen. Meanwhile, the freed iron ions wreak havoc in the lungs and destroy cells there.

93 posted on 04/17/2020 11:45:52 PM PDT by roadcat
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To: roadcat

“Sars-CoV-2 strips away iron ions in hemoglobin cells, so they can’t absorb oxygen let alone transport it to organs throughout the body.”

Where are you finding that?

Nothing like it is showing up at NIH or Nature.com


94 posted on 04/18/2020 12:05:00 AM PDT by Pelham (Mary McCord, Sally Yates and Michael Atkinson all belong in prison.)
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To: ProtectOurFreedom

I could just find an interview with the doctor in French. Do you have a link?


95 posted on 04/18/2020 12:12:28 AM PDT by Chgogal (Wuhan Virus, Chinese Virus, Kung Fu Virus - Wuhan Chinese Kung Fu Virus aka CCP virus.)
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To: Right_in_Virginia

Bkmk


96 posted on 04/18/2020 12:13:19 AM PDT by Right_in_Virginia
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To: Pelham

“Where are you finding that?”

http://web.archive.org/web/20200405061401/https://medium.com/@agaiziunas/covid-19-had-us-all-fooled-but-now-we-might-have-finally-found-its-secret-91182386efcb

“Here’s where COVID-19 comes in. Its glycoproteins bond to the heme, and in doing so that special and toxic oxidative iron ion is “disassociated” (released). It’s basically let out of the cage and now freely roaming around on its own.”

That’s the basic premise. The lengthy article explains in detail how Covid-19 will starve the body of oxygen, and what medical staff should look for when a suspected Covid-19 patient arrives. Several primary indicators:

elevated hemoglobin and decreased blood oxygen saturation.

pulmonary oxidative stress in both lungs at the same time.

your liver releasing an enzyme called alanine aminotransferase (ALT) to battle the loose iron ions.


97 posted on 04/18/2020 12:34:35 AM PDT by roadcat
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To: Lazamataz

This is fear-porn


98 posted on 04/18/2020 3:06:48 AM PDT by NY.SS-Bar9 (Those that vote for a living outnumber those that work for one.)
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To: Tolerance Sucks Rocks

Pretty scary stuff. Cytokine storms are no joke.


99 posted on 04/18/2020 4:52:01 AM PDT by HollyB
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To: Lazamataz
... the virus acts like no microbe humanity has ever seen.

Makes you wonder...

100 posted on 04/18/2020 5:15:18 AM PDT by Magnatron
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