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How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes
Science Magazine ^ | Apr. 17, 2020 , 6:45 P | By Meredith Wadman, Jennifer Couzin-Frankel, Jocelyn Kaiser, Catherine Matacic

Posted on 04/17/2020 7:29:29 PM PDT by Lazamataz

On rounds in a 20-bed intensive care unit (ICU) one recent day, physician Joshua Denson assessed two patients with seizures, many respiratory failure and others whose kidneys were on a dangerous downhill slide. Days earlier, his rounds had been interrupted as his team tried, and failed, to resuscitate a young woman whose heart had stopped. All shared one thing, says Denson, a pulmonary and critical care physician at Tulane University. “They are all COVID positive.”

As the number of confirmed cases of COVID-19 surges past 2.2 million globally and deaths surpass 150,000, clinicians and pathologists are struggling to understand the damage wrought by the coronavirus as it tears through the body. They are realizing that although the lungs are ground zero, its reach can extend to many organs including the heart and blood vessels, kidneys, gut, and brain.

“[The disease] can attack almost anything in the body with devastating consequences,” says cardiologist Harlan Krumholz, “Its ferocity is breathtaking and humbling.”

Understanding the rampage could help the doctors on the front lines treat the fraction of infected people who become desperately and sometimes mysteriously ill. Does a dangerous, newly observed tendency to blood clotting transform some mild cases into life-threatening emergencies? Is an overzealous immune response behind the worst cases, suggesting treatment with immune-suppressing drugs could help? What explains the startlingly low blood oxygen that some physicians are reporting in patients who nonetheless are not gasping for breath? ...

What follows is a snapshot of the fast-evolving understanding of how the virus attacks cells around the body, especially in the roughly 5% of patients who become critically ill. Despite the more than 1000 papers now spilling into journals and onto preprint servers every week, a clear picture is elusive, as the virus acts like no microbe humanity has ever seen. ....

(Excerpt) Read more at sciencemag.org ...


TOPICS: News/Current Events
KEYWORDS: bioweapon; chatforum; cv19; horror; timeline
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To: Bratch

Funny :)


41 posted on 04/17/2020 8:22:12 PM PDT by Lazamataz (China got this virus right off the bat.)
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To: Java4Jay
ish

No no no, you hold your head and go EESH! Here, try it again.


42 posted on 04/17/2020 8:23:58 PM PDT by Lazamataz (China got this virus right off the bat.)
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To: Opinionated Blowhard
And yet, it appears that a large number of people get it and barely even know they have it.

That is true of a lot of viruses. Cold and flu for example but many others as well.

43 posted on 04/17/2020 8:24:36 PM PDT by TigersEye (MAGA - 16 more years! - KAG)
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To: fwdude

Then how come a good number of people who contract it have relatively mild or NO reactive symptoms? Something doesn’t jive.

I was thinking the same thing. More people are surving than dying from it.


44 posted on 04/17/2020 8:25:34 PM PDT by chuckb87
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To: kalee

For later


45 posted on 04/17/2020 8:25:34 PM PDT by kalee
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To: dp0622

I’ve got an aunt in Arkansas in her upper 80’s.

She just moved to town from her house in the country. She lived alone out there the middle of farm land. All of her neighbors had moved out. She literally did not have a neighbor for 5 miles.

He daughter checks on her, but she no longer goes inside her new apartment. She brings her groceries and sits on the porch and talks to her.


46 posted on 04/17/2020 8:25:55 PM PDT by DannyTN
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To: Lazamataz

Hey thanks man. :)

I got my 2 aunts on staten island also. 78 and 88.

I’m the only child that didn’t move to NJ so i’m the go to guy :)

Hope you are coming along man. Last time you said very slowly but surely.

I hope it is still going in a positive direction.


47 posted on 04/17/2020 8:28:15 PM PDT by dp0622 (Radicals, racists dont point fingers at me I'm a small town white boy Just tryin to make ends meet)
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To: Lazamataz

That was the flu bro.


48 posted on 04/17/2020 8:30:34 PM PDT by SoCal Pubbie
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To: fwdude

Why do some people get laid out with influenza..and why do thousand die?

The thing with this one is the contagion factor. It is multiple times more contagious than those other viruses. I guess it clearly doesn’t ‘take’ with everyone, but spreads like a gas fire.

My guess is when we”open up” there will be more hot spots within 3 weeks. I am NOT suggesting any dramatic resurgence or huge death rate. But we aren’t don’t with this yet.


49 posted on 04/17/2020 8:31:21 PM PDT by Vermont Lt
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To: dp0622
I got my 2 aunts on staten island also. 78 and 88.

Dammmnnn dude, you got good genes. Our family, most everyone dies in their 90's. On my moms side, I got good genes too.

Hope you are coming along man. Last time you said very slowly but surely.

The vision issue resolved, in only three weeks. But I got enough of a warning that I am taking much better care of the Type II. :)

50 posted on 04/17/2020 8:31:42 PM PDT by Lazamataz (China got this virus right off the bat.)
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To: Lazamataz

I agree. Ignorant people who blithely dismisses this as the flu will be shocked to read this, if they will have the awareness to do so.


51 posted on 04/17/2020 8:32:18 PM PDT by nwrep
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To: SoCal Pubbie

Yeah, sure was. This virus is weird. Lots of people, it barely touches, but for those that get hit hard, it behaves so oddly.


52 posted on 04/17/2020 8:32:55 PM PDT by Lazamataz (China got this virus right off the bat.)
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To: Lazamataz

I am Very Glad to hear that.

90s is becoming more and more common.

I’ll be 52 in May.

Young buck when I first read this board. 32 years old...

Thought I was gonna take over the world.

The world won lol


53 posted on 04/17/2020 8:38:19 PM PDT by dp0622 (Radicals, racists dont point fingers at me I'm a small town white boy Just tryin to make ends meet)
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To: Tolerance Sucks Rocks

new thread
#46
https://www.freerepublic.com/focus/f-chat/3836310/posts


54 posted on 04/17/2020 8:41:36 PM PDT by RaceBannon (Rom 5:8 But God commendeth his love toward us, in that, while we were yet sinners, Christ died for)
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To: Lazamataz

new thread
#46
https://www.freerepublic.com/focus/f-chat/3836310/posts


55 posted on 04/17/2020 8:41:46 PM PDT by RaceBannon (Rom 5:8 But God commendeth his love toward us, in that, while we were yet sinners, Christ died for)
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To: dp0622

Ha! Me too.


56 posted on 04/17/2020 8:43:03 PM PDT by Lazamataz (China got this virus right off the bat.)
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To: Lazamataz

BFL WuHuChineseKungFlu ???????


57 posted on 04/17/2020 8:47:28 PM PDT by snooter55 (People may doubt what you say, but they will always believe what you do)
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To: ProtectOurFreedom

I saw a rebuttal of the Heme attack and disruption by a Phd and MD all in one. I didn’t buy it because the explanation you refer to seems altogether logical.


58 posted on 04/17/2020 8:51:54 PM PDT by Glad2bnuts (“If there are no absolutes by which to judge society, then society is absolute.” Francis Schaeffer)
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To: Lazamataz

It’s an anecdotal observation.


59 posted on 04/17/2020 8:53:49 PM PDT by reasonisfaith (What are the implications if the Resurrection of Christ is a true event in history?)
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To: Secret Agent Man

Has anyone used the IV Vitamin C, Thiamine + one other ingredient that escapes me right now, to treat the cytokine storm? It is a treatment for sepsis, that has saved many lives. I don’t know if it is in common usage today, but approximately 3 years ago I first heard of it. It took people who previously had a 3 in 100 chance of recovering, and brought people back to life at a 35% success rate. If I wasn’t so old I never would have cared to remember this, also I wouldn’t forget the ingredients they were using if I were younger either.


60 posted on 04/17/2020 8:57:14 PM PDT by Glad2bnuts (“If there are no absolutes by which to judge society, then society is absolute.” Francis Schaeffer)
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