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Depression gene found
News.com.au ^ | 02/26/2006 | By Clair Weaver and Andrew Chesterton

Posted on 02/25/2006 8:22:24 AM PST by oxcart

IN a world first, researchers from NSW have discovered the gene responsible for depression.

After 25 years' research, scientists have found that people who carry a particular gene are more likely to suffer depression regardless of their life experiences. The medical breakthrough will have major ramifications for diagnosis and treatment of the disease which affects one in four Australians.

The study, to be published in the prestigious British Journal of Psychiatry this week, shows that people who carry a short serotonin transporter gene are predisposed to depression.

Conversely, those who carry a long version of the serotonin transporter gene would be more resilient to whatever life throws at them.

Around 43per cent of the population is believed to carry the short version of the gene.

The breakthrough comes in the wake of a series of recent high-profile cases of depression, including former WA premier Geoff Gallop, the late rugby league legend Steve Rogers and former state opposition leader John Brogden.

Former Australian Olympic swimmer John Konrads and actor Garry McDonald were also sufferers. It is hoped the findings could be used to pre-warn carriers of their susceptibility and take early preventative treatment.

Mr Konrads described the breakthrough as exciting.

"I think it's wonderful to think that people who might have that doubt could confidentially find if they're conducive to depression or not, that would be fantastic," he said.

The serotonin transporter gene, which is responsible for our uptake of "feel good" serotonin and mood control, has been implicated in depression before - but this is the first and most conclusive evidence of its true role.


TOPICS: Culture/Society; Extended News
KEYWORDS: depression; depressiongene; disorders; gene; genetics; health; itwasattheduallalong; medicine; mentalillness; serotonin
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To: vimto
I suffer from depression - strong family history. I get on with life the best I can - I've got a supportive wife and kids. But I feel like crap virtually every day. If I could go home to be with the Lord I would, but I'm no quitter,

The Lord says to be of good cheer, that he has overcome the world.

I have a terminal disease for which there is no cure. I get up every morning and thank God for the day, and pray that I won't sqaunder the opportunities He gives me.

And I am almost NEVER depressed.

241 posted on 02/25/2006 11:07:01 PM PST by Jorge
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To: dc27

Goodness, dc, that sounds like bipolar disorder.

The "struggle to live with" stuff you describe is true. The best description of the "mixed state" I know of is "chainsaw personality" as in "the chainsaw school of human relations".

Recurrent depressions lasting weeks and months are typical with bipolar II. So is a real mean streak. Just to cap the whole thing off bipolar disorder gets worse with time.


242 posted on 02/26/2006 2:37:26 AM PST by Iris7 (Dare to be pigheaded! Stubborn! "Tolerance" is not a virtue!)
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To: Vision

"I promise you you're wrong."

You sound either manic or like a fool. "Promise me"?


243 posted on 02/26/2006 2:43:20 AM PST by Iris7 (Dare to be pigheaded! Stubborn! "Tolerance" is not a virtue!)
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To: Vision

Ah, manic, I see. Good old "chainsaw school of human relations." Lithium should work fine.


244 posted on 02/26/2006 2:44:39 AM PST by Iris7 (Dare to be pigheaded! Stubborn! "Tolerance" is not a virtue!)
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To: bonfire

You are describing bipolar disorder to a T.


245 posted on 02/26/2006 2:47:31 AM PST by Iris7 (Dare to be pigheaded! Stubborn! "Tolerance" is not a virtue!)
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To: Jorge

I rejoice for you - I hope this depression never visits you.

But joy in the Lord is mine even now - without Him I could not go on.

Note" - look at the psalms of David - he was very depressed.

Kind regards in Christ.


246 posted on 02/26/2006 4:11:07 AM PST by vimto
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To: Iris7

You seem paranoid, freaked out, and angry.

I promise you, you can get yourself out of your depression.


247 posted on 02/26/2006 6:18:07 AM PST by Vision ("There are no limits to growth because there are no limits of human intelligence" Ronald Reagan)
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To: vimto

you seem like a very good person.
i am very impressed by the sensitivity and kindness of a number of people on this thread.

companies keep coming out with new medications to help with depression, so it is possible that you may eventually not have to experience it very often.


248 posted on 02/26/2006 6:31:25 AM PST by drhogan
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To: drhogan
Appreciated. I have also been impressed by the comments and I think is shows the caliber and compassion of people on FR

kind regards
249 posted on 02/26/2006 7:10:28 AM PST by vimto
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To: Vision

Oh, yeah, I forgot the /sarcasm command. Heck.


250 posted on 02/26/2006 7:30:02 AM PST by muawiyah (-)
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To: Vision
Hey, it's at the cellular level. The scientists have discovered the gene responsible. In effect, we are discussing what you would find in an autopsy if you'd known where to look and had the equipment to detect it.

This stuff is tiny, eh?!

251 posted on 02/26/2006 7:44:32 AM PST by muawiyah (-)
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To: Vision

Yes, the attention, by others, really is spiritual in nature. Undoubtedly a different gene would work better for the victim.


252 posted on 02/26/2006 7:45:36 AM PST by muawiyah (-)
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To: Jorge

While looking down on so many from your lofty perch, I'm curious to know if the air is really that thin up there.


253 posted on 02/26/2006 7:48:49 AM PST by demkicker (democrats and terrorists are familiar bedfellows)
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To: Tunehead54

It's just a wild guess, but I think you forgot to take your meds:-)


254 posted on 02/26/2006 7:56:55 AM PST by demkicker (democrats and terrorists are familiar bedfellows)
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To: oxcart
Try exercise (running), its the only thing that keeps me sane.

It's really amazing how well that works. I've been trying to get a depressed friend to start walking briskly fifteen minutes a day and work his way up.

255 posted on 02/26/2006 8:05:07 AM PST by SupplySider
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To: SupplySider
I've been trying to get a depressed friend to start walking briskly fifteen minutes a day and work his way up.

My therapist told meof one of her patients who would come in, recline on the couch, and tell her that just breathing took all of her energy.

She's much better now but it can take a lot of effort to get to the point where someone can think about exercising. Once your friend can get to that point, things should come more easily. As my therpist says.... baby steps. Perhaps there is something that won't seem so insurmountable that you can help your friend achieve.

256 posted on 02/26/2006 9:23:46 AM PST by technochick99 (Firearm of choice: Sig Sauer....)
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To: Vision
I promise you you can figure it out.

The 'us' I was referring to was more of a generic one. I consider myself a survivor of it. And I was also being a bit on the sarcastic side, since greats such as Lincoln and Churchill were depressed.

While 'life pattern' sounds good, I think that there are several factors, all of which can interact in various ways. So, there is no single right way. I am glad you found your way out, but your way and my way (and the way of others) can be different, not one thing works for everyone.

257 posted on 02/26/2006 9:27:22 AM PST by technochick99 (Firearm of choice: Sig Sauer....)
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To: vimto
If I could go home to be with the Lord I would, but I'm no quitter,

People who have never suffered from depression don't often understand how the condition is worse than chronic pain. Thanks for your posting.

258 posted on 02/26/2006 9:31:23 AM PST by Casloy
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To: technochick99
The flaw in your analysis : those who feel sadness from time to time, or those who have blithe, oblivious happiness and are affected by little or nothing?

The latter probably don't exist; and depression is nothing at all like the former.

Of course the latter exist. Sociopaths, psychopaths, some narcissists and borderlines, extremely self-centered people, along with many abusive pathologies, or even people caught up in some types of emotion-driven movements, can present that kind of behavior. With the right medications (or the right desensitizing indoctrination) the majority of entire populations can exhibit it.

This article, and our discussions here, have nothing to do with what you are posting.

My reply was about the article, not the discussion. I think it has a lot to do with it. I have no control over whether you see that, or whether you agree or not.

259 posted on 02/26/2006 10:15:34 AM PST by In_25_words_or_less (It's more a guideline than a rule.)
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To: muawiyah
There's no way it's in the genes.

Look at almost any honest biography. Lives are filled will all sorts of struggle, bouts of depression and such. It is a behavioral pattern producing negative emotions that can be overcome. How about an ugly gene? If you're ugly and people let you know it, that's bound to be depressing until you can overcome those thoughts.

Todays society seems to arrogantly think that life should naturally be free of pain and struggle from birth to death. And this study that says depression is genetic fits that pattern of helplessness even while we've been born into the wealthiest culture the world has ever known. It's really silly to me. It's kind of like they've decided that character is no longer an issue.
260 posted on 02/26/2006 10:57:03 AM PST by Vision ("There are no limits to growth because there are no limits of human intelligence" Ronald Reagan)
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