Ebola Recombinant Linked to Mystery Illness in Sichuan China? (BIOWEAPON ALERT!!)

Recombinomics ^ | 30 Jul 05 | Recombinomics

[datura]

 

							Home	Founder	What's New	In The News	Contact Us
				Paradigm Shift Viral EvolutionIntervention Monitoring Vaccine Screening Vaccine Development Expression Profiling Drug Discovery Custom Therapies Patents			Commentary . Ebola Recombinant Linked to Mystery Illness in Sichuan China? Recombinomics Commentary July 30, 2005 D: "It's alright. We ran tests on those samples and isolated the SZ77++A3231 virus." I: "What is this SZ77++A3231 virus?" D: "This is a strain of the Ebola virus." I: "Would you like to comment about it?" D: "It's rather impossible to totally explain it." I: "I can understand so, but why is the term "less-infectious" always affixed to our version of the Ebola virus?" D: "There are 2 reasons for doing so. First, to reduce panic among the people should it ever leak. And second, the Ebola virus has evolved in China. Re-combination has been detected. Most prominently at the portion which determines its effect on humans (very technical description, I can't describe it. sorry.). Also, abrupt breaks in the sequencing were detected, leading to changes in the incubation period. (Or possibly "changes in the incubation period were detected") I: "How were these viruses classified then? / Could you elaborate more about the various strains?" D: "Previously, strains of Ebola in China always had the EBO prefix. Subsequently following information leaks, the classification method was changed. We stopped using the EBO prefix. Instead, coupled with the discovery that the virus had become more virulent and lethal, we re-named the strains according to the placed where they were first discovered. For example, the strain in June became the SZ77++A3231. Sometimes, we don't even use their place of discovery, instead directly naming it the ++A3231." I: "In that way, the Ebola virus wouldn't even be brought into the picture." D: "Precisely, viruses such as the Ebola are national secrets." The above comments by a physician involved in testng samples from patients in the mysterious swine outbreak in Sichuan indicate that one of the agents isolated is a recombinant Ebola virus originally isolated from Shenzen.  Prior reports had listed the names and characteristics of various Ebola isolates and EB-SZ-277 was capable of infecting birds.  SZ277++A3231 is a recombinant version of SZ-277 isolated from a patient.  The discussion indicates China has an active Ebola project and the virus is rapidly evolving via recombination. It was not clear from earlier reports if the agent was isolated and sequenced, but this interview leaves little doubt that both isolation and sequencing of Ebola is quite active.  It is unclear if the recombination is related to the region of identity between Ebola and H5N1. Ebola is considered a state secret, so there are no reports of the virus or availability of virus or sequences. The interview also indicates that the streptococcus suis is not the cause of the illness.  It is present in pigs and is merely activated by infectious agents, which include Ebola, plague, and an un-named virus which is considered "dangerous".  The emphasis is on the bacteria because it can produce similar symptoms.  The symptoms of the patients match pandemic flu of 1918, and H5N1 can produce such symptoms. The interview, if accurate, would support the role of agents other than be bacteria, in the spread on prgression of the illness.  streptococcus Suis does not produce the high case fatality rate, and can be treated with antibiotics, as can plague.  The high case fatality rate also supports the involvement of a virus and the proximity to Qinghai Lake keeps H5N1bird flu and migratory birds on the short list of explanations for the raid spread of the fatal disease that is resistant to antibiotic treatment. Media Resources

Home | Founder | What's New | In The News | Contact Us

Webmaster: webmaster@recombinomics.com
© 2005 Recombinomics.  All rights reserved.

[EBH]

http://www.freerepublic.com/focus/f-news/1399613/posts
Avian Flu Surveillance Project

[Myrddin]

Native Americans have problems in the ethanol->acetaldehyde->acetic acid metabolism path. The acetaldehyde->acetic acid path is slower, so aldehydes build up and alcohol metabolism is slowed. The biochemical basis for why Native Americans shouldn't drink alcohol. A chemical weapon that exploits that slower path would have a more severe impact on a Native American.

[datura]

I've asked the moderators to include a top bar thread called "Pandemic" - they said that they would.

Unfortunately, this is no longer just H5N1 - but something far more sinister and deadly.

[processing please hold]

"There are 2 reasons for doing so. First, to reduce panic among the people should it ever leak. And second, the Ebola virus has evolved in China. Re-combination has been detected. Most prominently at the portion which determines its effect on humans (very technical description, I can't describe it. sorry.). Also, abrupt breaks in the sequencing were detected,

I read that, and was just re-reading it again.

They won't be able to control that genie.

[datura]

Thank you - now I know why I quit drinking years ago. That also explains to some degree the heartburn I fight so often - if my decades old chemistry serves me correctly.

[datura]

No, but they're arrogant enough to try.

They were also arrogant (and willing to try their hypothesis) on our economic system to pay bin Laden to do 911.

They had more than foreknowledge.

[processing please hold]

Thanks for the link. Bookmarked...as is this one.

[EBH]

We've been following this for a while now, most updates and articles are placed there and not on the News Forum board. There is a fine group of people involved in the online think tank. You're welcome for the link.

[Myrddin]

I attended a seminar in grad school that featured a Native American speaker. He did an excellent job of explaining the fine details of the underlying alcohol metabolism problems in Native Americans.

My wife is 1/4 Cherokee. Our oldest son has no need of a razor...just as observed in many other Native Americans. Her dad was a hopeless alcoholic. My #2 son shares a need to shave in the morning and again in the evening if going out to avoid looking like an unshaven bum. My wife also shares the heartburn problem. Nexium or workalikes help.

[processing please hold]

They were also arrogant (and willing to try their hypothesis) on our economic system to pay bin Laden to do 911.

That didn't turn out as they expected it would...and neither would this. They aren't the only country playing with bio-weapons.

[xVIer]

Health officials investigate unusual incidence of Creutzfeldt-Jakob Disease
http://seattlepi.nwsource.com/local/aplocal_story.asp?category=6420&slug=ID%20Creutzfeldt%20Jakob%20Cluster

---

More cases of livestock anthrax are found
http://www.zwire.com/site/news.cfm?BRD=1302&dept_id=181981&newsid=14948306&PAG=461&rfi=9

---

---

Off-topic but does anyone else feel suspicious about why this is going on?

[datura]

Granted. They've proven themselves to be willing to "roll the dice" a lot quicker than we are, for instance. (One reason that they're still 3rd world.)

[tortoise]

You are obviously trained in this field - I'm certainly not - so I'd appreciate your educated opinion: Is this "new" strain natural or manmade?

I am not an expert, just an educated observer.

I find it improbable that someone would splice an Ebola type virus into an Influenza type virus for a few reasons. First is simply that these two viruses are significantly different, though of the same broad class of viruses (neg RNA). Ebola has fairly stable and simple RNA, while influenza has complicated segmented RNA that mixes things up regularly. On the surface, it seems difficult to splice the interesting parts between the two in a way that would actually function due to the basic structural and organizational differences. It would be a bit like trying to run old mainframe binaries on a Macintosh. And even if it is possible, would the Chinese have the savvy to pull it off?

A much easier and cheaper approach is to splice from within one of the virus sub-families, which is more analogous to trying to make software run that is written for two very different operating systems but the same underlying hardware. Still a pain, but much easier. And in fact, a lot of state-of-the-art virus engineering works more along these lines.

You might be able to splice a very specific little bit of influenza into ebola, but probably not the other way around. I do not know enough about the details of these virus families to say why you might want to do that as opposed to engineering a virus to some end in another fashion.

[processing please hold]

Once again, I am not arguing that this swine "flu" outbreak is bio-engineered. However, it is mysterious from a technical point of view and the Chinese government behavior is extraordinarily obfuscatory, even compared to the SARS situation. Whether or not the swine disease has military origins, I believe the Chinese would be willing to sacrifice a major fraction of their population in an assault on Taiwan and the west.

I know the WHO is dying to get into China to see what is up there, but are refused the latitude they seek.

China must know that we would retaliate with bio-weapons of our own. I'm just trying to get my mind around that they would actually risk destroying the world to end up conquerors of a dead planet. Once I get past that irrational and insane plan.......

[datura]

You know, whenever I read Pro-med Mail, I get the same question in the back of my head.

Dengue fever, for instance - is widespread. Malaria still kills tens of thousands (or more) yearly.

[datura]

You can't evaluate the ChiCom power structure using our logic or cultural filters. It won't work.

[ovrtaxt]

A caucasian guy in my church went to China 2 yrs ago to adopt a girl. He got SARS, but thankfully he recovered.

My sister-in-law went there 6 mos. ago to adopt a boy. No SARS, but they said it was pretty dirty. They went to the northwest province, Xinjiang.

[ovrtaxt]

As of late, they have more social classes than ever before. The middle class is less restless - since they are the ones winning in the current system. The uneducated agricultural class in China is also the one raising Hell with the government. They're the ones being executed by firing squads. They're also the ones dying from this outbreak - not the middle or upper class.

It's probably safe to say that the underground church there is considered a very serious threat to the 'revolution' too.

[processing please hold]

You can't evaluate the ChiCom power structure using our logic or cultural filters. It won't work.

Damn, I'm screwed then. Any suggestions on just how I go about evaluating it? I'm wide open to suggestions. Think of my mind as a blank slate...how?

After 9-11 I figured out PDQ who wanted to kill us.

[datura]

The last paragraph is the key:

Boxun Description of Ebola in China

Recombinomics Commentary
July 19, 2005

1. EB-SZ type: It was found in Shenzhen of South China. People contracted the virus showing severe illness, and they were infected through the contact of blood. Incubation period is 2-4 weeks. Some individual cases have incubation period up to 6 months. Some cases are asymptomatic. Those infected people's immunity drops suddenly that triggers other co-infections and complications. When non-Ebola virus related infections become severe, it could lead to diathesis from the major blood vessels. In severe cases, blood vessels disintegrate; muscular tissues became fluid-like; patients died of lack of oxygen due to haemorrhage. After the case die, the disintegration symptoms persist with the change of room temperature, ie above 12.4 degree Celcius. The process continues until the carcass completely disintegrates. The disintegration process slows down when temperature is lower than 8.7 degree Celcius; and the process halts at below 4 degree Celcius. Therefore, the best treatment for infected person is to use low temperature therapy. To treat the deceased cases, it is better to seal the body under low temperature. To disinfect the environment where the cases die has to use both high temperature disinfection and low temperature disinfection with the assistance of potent medication.

2. EB-ST type: It was found in Shantou of South China. People contracted the virus showing severe illness. Transmission is unknown. Incubation period: 30-120 days. Infected people have localized maculopapular rash. Cases occur in the form of diathesis in the smallest capillaries that lead to necrosis of the involved tissues. The characteristic of this virus is its intermittent exacerbation of the symptoms. This virus is suspected to be the mutated by-product of Ebola virus and other viruses. The confirmative diagnosis is usually made by the identification of EB-SZ-like virus in the tissues of deceased cases.

3. EB-HN type: It was found in Hunan of Central China. Transmission is unknown. Incubation is about 30-60 days. Infected cases experience discomfort due to the localized diathesis. After the disintegration of blood vessels, patients experience symptoms related to blood loss. Most of the deceased cases' heavily infected organs were in their lungs. If the blood vessels of the internal organs were infected, it will cause hepatic damage. Deceased case's face and bottom will disintegrate within 2-8 hours afterwards; their nails also fall apart. Autopsy found that the tissues of tendons were as soft as muscle. The deceased cases' blood are contagious. Contact through other means will not lead to infection of the virus.

4. EB-FJ type: It was found in Fujian province of South China. The virus was transmitted through the carrier's blood. Incubation period is about 20-30 days. Infected people will become immunocompromised that leads to influenza induced pneumonia and bleeding in the lungs. Subsequently, it leads to respiratory failure. Autopsy found that the vessels in the deceased cases' lung were fluid like; other tissues were normal. Deceased cases displayed purplish spots in their necks.

5. EB-ZJ type: It was found in Zhanjian of South China. Not much details on this virus subtype.

6. EB-SZ77 type: It was found in Shenzhen of South China (adjacent to Hong Kong). This virus could infect birds.

The above human translation of a boxun report raises serious questions about Ebola infections in China. It has not been independently confirmed and Ebola has not been reported outside of Africa. The above report offers no genetic details on the relationship between the above isolates and the various sequenced Ebola and Marburg isolates.

The boxun reports on H5N1 bird flu strains appear to be quite believable and are supported by China's refusal to allow WHO visit the recent sites of H5N1 infections in Xinjiang province as well as the refusal to share sequence data on isolates from the latest outbreak.

Other boxun documents indicate details of H5N1 and Ebola infections are considered state secrets, which clearly if true, is cause for concerns. China's recent actions of limiting access and distribution of strains and sequences increases the credibility of the boxun reports.

Moreover, H5N1 and Ebola have a region of sequence identity between HA and spike genes.