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How exercise-induced migration of mitochondria protects the brain against stroke
Medical Xpress / Juntendo University / MedComm ^ | Jan. 24, 2025 | Toshiki Inaba et al

Posted on 01/25/2026 8:44:27 PM PST by ConservativeMind

Physical rehabilitation and symptom management still remain the mainstay of treatment for stroke, as clot removal or dissolution is effective only within a narrow time frame after the stroke. After that, many patients are left with long-term problems like difficulty walking, speaking, and memory decline.

Exercise has been beneficial in preventing strokes and improving recovery. However, the majority of these patients, being elderly, are too frail to exercise enough to gain these benefits.

In a study, a team of researchers explored how exercise protects the brain against stroke at a biological level through mitochondrial migration.

"It was during my research fellowship that I first observed that these mitochondria could travel from one cell to another," explains Dr. Miyamoto.

The team used mouse models that mimic stroke as well as dementia. Some mice from both these groups were then made to perform low-intensity treadmill exercise.

The researchers then compared brain damage, movement, memory, and changes in brain, muscle cells, and mitochondrial dosage and activity among the mice that exercised and those that did not. Mice that underwent treadmill exercise showed clear benefits, such as less damage to the white matter and myelin, better memory and movement, and mitigation of post-stroke complications.

Notably, exercise increased mitochondrial levels in muscle and blood, facilitating their migration between tissues via platelets. The platelets act like delivery trucks, carrying mitochondria produced in the muscle cells to the brain cells, including neurons and their support cells, such as the protective myelin-forming cells (oligodendrocytes) and the star-shaped astrocytes, which form a protective barrier between the blood and the brain.

Once in the brain, these mitochondria helped brain cells in the damaged area, as well as in the surrounding region, called the penumbra, survive under low-oxygen conditions, supported repair of white matter, and reduced post-stroke complications.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
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Exercise causes mitochondria, the energy producers for cells, to migrate to other cells needing a boost.

The experiments show it was helpful for stroke and stroke recovery.

1 posted on 01/25/2026 8:44:27 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

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2 posted on 01/25/2026 8:45:03 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

C.M. Thank you! Good information to have!


3 posted on 01/25/2026 8:54:14 PM PST by Pete from Shawnee Mission ( )
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To: ConservativeMind

Thanks. Very useful information.I had Vertigo seven weeks ago and spent 5 days in the hospital followed by 3 weeks in really nice nursing home Had an MRI at hospital to be sure I didn’t have a stroke.

Tech said my brain looked fine but I need to dfrink more WATER, so I am. Having another brain scan very soon so we’ll see what that shows. Still taking anti-dizziness pills for vertigo, not too worrisome, it’s 89% better. Unpleasant but not really scary.

Never heaard of Vertigo before. I hate it. Sucks enough to have lousy vision.


4 posted on 01/25/2026 9:08:15 PM PST by Veto! (Trump is Superman)
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To: ConservativeMind

Very intersting.


5 posted on 01/25/2026 9:45:31 PM PST by metmom (He who testifies to these things says, “Surely I am coming soon." Amen. Come, Lord Jesus….)
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To: Veto!

I experienced horrible, room-spinning vertigo about five years ago. 14 hours in emergency room, no treatment, a couple quick tests that took a half hour, and they sent me home with the world still spinning. They never did figure it out. But, really...14 hours in emergency room without treatment?


6 posted on 01/26/2026 2:42:50 AM PST by freepertoo
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To: freepertoo

“But, really...14 hours in emergency room without treatment?”

We’re you wearing your Trump shirt?


7 posted on 01/26/2026 5:22:18 AM PST by MayflowerMadam ( "Trouble knocked at the door, but, hearing laughter, hurried away". - B. Franklin)
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To: freepertoo

14 hours in emergency room without treatment…. But I’m sure they collected the co-pay quickly and had a bill ready a discharge.

Hope you’re on the road to recovery, best wishes.


8 posted on 01/26/2026 6:06:11 AM PST by Made In The USA (One and Two and Three and Four and)
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To: ConservativeMind

Bkmk


9 posted on 01/26/2026 6:10:08 AM PST by sauropod
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To: ConservativeMind
I’ve never heard of organelles moving from one cell to another. Fascinating.

If true, this gives another reason to exercise and keep mitochondria healthy.

10 posted on 01/26/2026 6:49:56 AM PST by The Truth Will Make You Free ( )
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