Successful 40-Hz auditory stimulation in aged monkeys suggests potential for noninvasive Alzheimer's therapy

Medical Xpress / Chinese Academy of Sciences / Proceedings of the National Academy of Sciences ^ | Jan. 6, 2025 | Zhang Nannan / Wenchao Wang et al

[ConservativeMind]

A research team has demonstrated for the first time in non-human primates that auditory stimulation at 40 Hz significantly elevates β-amyloid levels in the cerebrospinal fluid (CSF) of aged rhesus monkeys, with this effect persisting for over five weeks.

The study provides the first non-human primate experimental evidence supporting the use of 40-Hz stimulation as a noninvasive physical therapy for Alzheimer's disease (AD), revealing significant differences between primate and rodent models.

Researchers conducted the study using nine aged rhesus macaques (Macaca mulatta) aged 26–31 years. These aged individuals developed widespread spontaneous amyloid plaques in their brains, effectively mimicking the Aβ pathological feature of human AD and making them an ideal translational research model.

Using a randomized controlled design, the experimental group received one hour of 40-Hz auditory stimulation (using a 1-kHz pure tone) daily for seven consecutive days. After the stimulation period, levels of the key Aβ42 and Aβ40 proteins in the monkeys' CSF increased by 205.61% and 201.00%, respectively, with statistically significant differences. These results are consistent with previous findings in mouse models and support the hypothesis that 40-Hz stimulation facilitates the clearance of β-amyloid from the brain into the CSF.

Remarkably, CSF Aβ concentrations remained elevated when measured again 35 days (five weeks) after the stimulation ended, showing no significant decline from the levels measured immediately post-treatment. Such a sustained long-term effect has not been observed in any previous mouse model studies.

Although currently approved anti-Aβ monoclonal antibody therapies can slow early-stage AD progression, they are associated with significant risks, including cerebral edema and hemorrhage. In contrast, 40-Hz auditory stimulation is a noninvasive, low-cost physical intervention that demonstrates therapeutic promise, supporting its use as a complementary or alternative therapeutic strategy for Alzheimer's disease.

[ConservativeMind]

This 40 Hz frequency is an effect generated between both of your ears. There is a 40 Hz difference between them. Your brain uses it to enhance it’s own processes.

This helped Alzheimer’s brains dump beta-amyloid into the cerebral spinal fluid, getting rid of them in the brain. Strangely, the effect lasted five weeks after use.

I have a very inexpensive app (a couple dollars) for my iPhone that generates this and other tones for brain wave enhancement. It’s called “Brainwave 37 Binaural Series,” also known as “Brainwave Advanced Binaural Programs,” with a set of Brainwave apps for around $10 (I have the whole set). There is no subscription.

Use it with headphones to get the best needed stereo effect.

[ConservativeMind]

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[dadfly]

bookmark.

[Seaplaner]

Thanks CM!

I know some folks who might want to try this. And, what's to lose?

[Montana_Sam]

ping!

This is quite interesting, and will be a god-send if it proves efficacious.

[aquila48]

Bookmark

[SaxxonWoods]

Thanks, great info.

[aquila48]

Is there one for android?

[ConservativeMind]

The company that makes the app and the bundle of apps does not appear to make one for Android.

https://www.banzailabs.com/about.html

[KittyKares]

Oh no. I’m an android user, too.

[KittyKares]

I just sent them an email asking if they make one for Android.

[aquila48]

Just checked android Play Store. There are several similar apps.

One is called “Brain Waves Pro Binaural Beats”

[aquila48]

See post 12.

[ConservativeMind]

Get an app that does not have a subscription.

[Paul R.]

Interesting. In Nature, low frequency sounds are often associated with danger. The idea they might enhance brain function seems logical.

HOWEVER, beyond a certain point, perhaps the effect becomes deleterious. You all know what I’m talking about...

[Libloather]

Aren’t aged monkeys the same as old monkeys? Gonna need a biologist to figure out all this.

[Cobra64]

I also just ordered the entire set of five. Which one deals with the 40hz sound that retards Alzheimer’s?

[ConservativeMind]

The one just called “Brainwave.”

“Gamma-40 Focus” is one that just does that, but it is also in as a part of other brainwave settings/programs in that selector.

Read the brainwave frequencies each offers in the description, which is the button on the lower left to the right of the wrench.

[Kid Shelleen]

According to GROK:

AlzLife (iOS/Android app): A science-backed brain training app that integrates 40 Hz light pulses + 40 Hz sound stimulation (pulsed tones) with cognitive games, meditations, and videos. Users report it feels effective for memory/focus, with timed 40 Hz elements timed to reinforce brain activity. It's designed for older adults and inspired by GENUS research. (Search "AlzLife" in app stores.)

YouTube: Abundant free options — search "40 Hz pulsed auditory stimulation," "40 Hz gamma clicks," or "40 Hz isochronic tones." Channels offer hour-long loops of sharp pulses/clicks or modulated tones (e.g., "40 Hz Study Music - GAMMA" with rhythmic elements). Use good headphones/speakers; some combine with nature sounds.

[trebb]

Interesting - seems ironic since low frequency weapons can be as high as 20Hz - I wonder where the line is between “possibly helping” and causing severe damage.