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Colorado scientists say the drug Leukine halts brain cell loss in patients with Alzheimer’s and could improve cognition
https://www.cpr.org/ ^ | · Dec. 19, 2025 | Andrea Dukakis

Posted on 12/21/2025 1:17:43 PM PST by bitt

A paper published today in the journal Cell Reports Medicine offers new hope for an Alzheimer’s drug that doesn’t just slow cognitive decline but may reverse it. The study, by researchers at the University of Colorado Anschutz, found that Leukine or GM-CSF, a drug long-approved to treat other conditions, was able to stop brain cells from dying in Alzheimer’s patients when measured in a blood test. Brain cell death is a hallmark of Alzheimer’s disease.

“The main thing that we found…is that the people who were treated with Leukine or GM-CSF actually lost the ability to kill their nerve cells…to such an extent that it reduced nerve cell death to what would be the equivalent of a normal person about five years old,” Huntington Potter, director of the University of Colorado Alzheimer’s and Cognition Center and senior author of the study said.

The study also found that a simple blood test can measure brain cell death and damage, a phenomenon that begins in early childhood and becomes more acute as we age.

The findings add to previous research at CU Anschutz which found that Alzheimer’s patients given Leukine showed improvement in other blood biomarkers of the disease, including brain amyloid and neurodegeneration.

Potter said patients also improved in one test of memory, indicating the drug may also improve cognition , something other Alzheimer’s drugs currently on the market don’t do.

“All other Alzheimer's drugs that have been published and certainly the ones that have been approved only slow the course of the disease. They do not improve it.”

Potter said those drugs also come with adverse side-effects, while Leukine seems to be well-tolerated.

“Leukine or GM-CSF has been FDA approved for decades and has been used to treat some 500,000 people with very little in the way of serious side

(Excerpt) Read more at cpr.org ...


TOPICS:
KEYWORDS: alzheimers; colorado; dementia; gmcsf; leukine; leukinealzheimers; tcoyh
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1 posted on 12/21/2025 1:17:43 PM PST by bitt
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To: null and void; aragorn; EnigmaticAnomaly; kalee; Kale; AZ .44 MAG; Baynative; bgill; bitt; ...

p


2 posted on 12/21/2025 1:18:02 PM PST by bitt (<IMG SRC=' 'WIDTH=500>)
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To: ConservativeMind

Ping!..................


3 posted on 12/21/2025 1:23:37 PM PST by Red Badger (Iryna Zarutska, May 22, 2002 Kyiv, Ukraine – August 22, 2025 Charlotte, North Carolina Say her name)
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To: bitt

“Leukine or GM-CSF has been FDA approved for decades and has been used to treat some 500,000 people with very little in the way of serious side effects,” Potter said. “ It’s one of the safest drugs that has been studied.”

Still, Potter cautions, more research is needed before Leukine can be used as a drug for Alzheimer’s disease.

“No one should go out and try to take Leukine or prescribe it for Alzheimer’s disease until the studies are finished and the FDA has given its approval,” Potter said. “That would be potentially dangerous.”

__________

Seems a bit contradictory on the danger.

I wonder how the right to try law comes into play here.


4 posted on 12/21/2025 1:30:04 PM PST by jacknhoo (Luke 12:51; Think ye, that I am come to give peace on earth? I tell you, no; but separation.)
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To: bitt

Colorado...wot...wait....Put it in the water...maybe Tina Peters gets released.


5 posted on 12/21/2025 1:31:07 PM PST by spokeshave ( Angry Dads. Grumpy Grandads, Curmudgeons & old Geezers)
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To: bitt

When the “scientists” develop a medication/therapy that addresses the huuuuge mental illness that is liberalism, I will start paying attention.


6 posted on 12/21/2025 1:31:07 PM PST by Ronaldus Magnus III (Do, or do not, there is no try )
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To: Ronaldus Magnus III

How on Earth could you trust anything coming from colorado?


7 posted on 12/21/2025 1:49:26 PM PST by skinny old man (Still lurking and posting after all these years(27 yrs ?)(more ?)(seems like more...))
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To: skinny old man
"How on Earth could you trust anything coming from colorado?"

Exactly...

8 posted on 12/21/2025 1:57:06 PM PST by SuperLuminal (Where is rabble-rising Sam Adams now that we need him? Is his name Trump, now?)
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

Thanks Red Badger!

9 posted on 12/21/2025 2:00:48 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: bitt

Bump


10 posted on 12/21/2025 2:16:27 PM PST by KC Burke
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To: bitt

Well, what is the “simple” blood test mentioned? And why don’t Drs seem to order it for people over 60?


11 posted on 12/21/2025 2:23:16 PM PST by Oystir ( )
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To: bitt

interesting


12 posted on 12/21/2025 2:58:02 PM PST by MarlonRando
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To: Oystir

UCH-L1, NfL I believe is the FDA approved test, but may be approved only for assessing traumatic brain injury and chronic neurodegeneration (Parkinsons, Alzheimers, MS etc) ?


13 posted on 12/21/2025 3:15:51 PM PST by erlayman (E )
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To: bitt

bttt


14 posted on 12/21/2025 3:38:57 PM PST by thinden (Buckle Up!)
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To: jacknhoo

“ No one should go out and try to take Leukine or prescribe it for Alzheimer’s disease until the studies are finished and the FDA has given its approval,” Potter said. “That would be potentially dangerous.” So why was this caution not recommended regarding taking the Covid vaxx, that obviously was poorly, to never, properly studied or tested, even though FDA had approved it? So the FDA approval is critical, though proven to be useless or dangerous with the SARS-CoV-2 vaxx.


15 posted on 12/21/2025 3:46:26 PM PST by IWONDR ( )
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To: IWONDR

Good point!


16 posted on 12/21/2025 3:59:11 PM PST by jacknhoo (Luke 12:51; Think ye, that I am come to give peace on earth? I tell you, no; but separation.)
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To: bitt

Bkmk


17 posted on 12/21/2025 4:01:55 PM PST by sauropod
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To: bitt

“a drug long-approved to treat other conditions”

Like Ivermectin! So the government or medical establishment will forbid it!


18 posted on 12/21/2025 4:28:44 PM PST by ProtectOurFreedom
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To: bitt

Those folks in Colorado seem to know an awful lot about drugs. So, maybe they could be right about that.


19 posted on 12/21/2025 4:34:24 PM PST by unread ("A nation can survive its fools, and even the ambitious. But it cannot survive treason from within.")
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To: bitt
"... it reduced nerve cell death to what would be the equivalent of a normal person about five years old"

The Benjamin Button wonder drug!!


20 posted on 12/21/2025 4:41:45 PM PST by ProtectOurFreedom
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