Click here: to donate by Credit Card
Or here: to donate by PayPal
Or by mail to: Free Republic, LLC - PO Box 9771 - Fresno, CA 93794
Thank you very much and God bless you.
Posted on 08/23/2025 9:17:23 PM PDT by ConservativeMind
High levels of triglycerides, the most common type of fat in the body and the foods we eat, directly cause abdominal aortic aneurysms, according to a study in mouse models.
Researchers identified triglyceride-rich lipoproteins and proteins that regulate triglyceride metabolism, including APOC3 and ANGPTL3, as causal drivers of abdominal aortic aneurysm.
The study challenges the longstanding belief that triglycerides are merely biomarkers of vascular disease and instead demonstrates that they play a direct role.
"We have known that hyperlipidemia is a risk factor for aortic aneurysm, but this multidimensional study pinpoints hypertriglyceridemia as an essential contributor to the development and growth, as well as dissection and rupture, of aortic aneurysms," said Eugene Chen, M.D., Ph.D.
"Our findings suggest that managing triglycerides could become a powerful therapeutic strategy."
Using three different mouse models of hypertriglyceridemia, the research team demonstrated a triglyceride dose-dependent effect on aneurysm severity.
Moderate elevations in triglycerides accelerated aneurysm formation, while higher levels led to aortic dissection.
Mice with severely elevated triglyceride concentrations developed more severe complications consistent with aortic rupture.
Further investigation revealed that elevated triglycerides and related fatty acids, particularly palmitate, impaired the maturation and activity of lysyl oxidase, a critical enzyme that maintains the structural integrity of the aortic wall.
This enzyme dysfunction weakened connective tissue and promoted aneurysm progression.
By overexpressing LOX in the aorta, researchers effectively blocked the damaging effects of hypertriglyceridemia in the mouse models, confirming the mechanism.
Standard lipid-lowering therapies, such as niacin, didn't sufficiently reduce triglyceride levels to a protective range.
However, investigators found success with experimental antisense oligonucleotide therapy. The drug candidate targets the ANGPTL3, which is secreted in the liver and affects how the body breaks down fats.
The treatment dramatically lowered triglyceride levels by up to 50% and prevented aneurysm formation and dissection in multiple mouse models.
(Excerpt) Read more at medicalxpress.com ...
|
|
Click here: to donate by Credit Card Or here: to donate by PayPal Or by mail to: Free Republic, LLC - PO Box 9771 - Fresno, CA 93794 Thank you very much and God bless you. |
This is what I needed to know to finally help prevent it.
Is there ANYTHING that won’t kill ya?
I’m just glad I’m not a mouse.
Ping
“The treatment dramatically lowered triglyceride levels by up to 50% and prevented aneurysm formation and dissection in multiple mouse models.”
Good to see that they’re slowly realizing that Triglycerides is the BIG health threat - SOME OF US have known that for at least a decade. By the way, another ‘treatment’ to greatly lower triglycerides is to simply not eat carbs, or at least greatly minimize them.
As someone who had Open Heart Surgery to repair an aortic aneurysm, they are no joke.
I was born with a Bicuspid Aortic Valve about 15 years after discovery, I was diagnosed with severe aortic stenosis, one of the tests prior to surgery to repair the valve was a CT Scan with contrast that showed the aneurysm.
I was told at the time, I could have a less invasive procedure to fix the valve and 12-18 months later Open-heart surgery to repair the aneurysm or open-heart surgery immediately to repair the valve and aneurysm, I chose to have the open heart surgery immediately.
I learned that what makes aneurysms so dangerous is the person experiencing the aneurysm suffers no symptoms prior to a dissection or rupture and that aneurysms usually are found as a result of looking for something else.
That doesn’t make sense...
High triglycerides cause plaque build up in the arteries, causing a narrowing, causing a clog = heart attack or stroke.
Aneurysms are a ballooning of the arterial walls (a weakness in the hose if you will). So this study says they’re simultaneously causing the clogging AND the ballooning of the arteries? Ehhhh... Maybe because the clogging causes HBP but that still doesn’t completely jive...
Tell that to the AHA and Diabetes association... Cars r gud!
Ehh... I’d be careful labeling triglycerides as evil. They are literally the fuel your brain uses for all its metabolic processing. Exceptionally high levels of triglycerides are not good, but classifying them as a killer is misguided. Everything in the body is there for a reason. It’s a balancing act.
“The triglyceride to HDL ratio is a proxy for LDL particle size. A higher ratio suggests a greater proportion of smaller, denser LDL particles, which are more atherogenic (contribute to plaque buildup in arteries).” (ChatGPT)
My ratio was near 1.0 perfect, but then jumped to 3.6. Last check was back in the 1’s.
...We present an interesting case where a patient with heterozygous FH (HeFH) and elevated triglycerides (TG)-controlled for years on medication and apheresis-experienced significantly elevated TG, one day after receiving his second Pfizer-BioNTech COVID-19 vaccine dose. It is not known whether this adverse event may be seen in other FH patients and may be worth assessing in such patients to determine the possibility of a rare adverse reaction from a COVID-19 vaccine.
And from 2022...
“Ehh... I’d be careful labeling triglycerides as evil. They are literally the fuel your brain uses for all its metabolic processing.”
Jeeze, now you got me reading about having triglycerides that are too low, but man, they are CLUELESS. They blame low triglycerides on not eating enough fat, when it’s CARBS that raise triglyceride levels!!!
But I guess you’re right in that triglycerides that are super-low, below 40, indicate some other, serious condition, exists. So it could be a symptom to look more closely at. Personally, I’m down to 48 (’normal’ is considered below 150) by avoiding most, but not all carbs (I’m probably not even in Ketosis), and so I eat a ton of fat. All other labs are perfect.
“Tell that to the AHA and Diabetes association... Carbs r gud!”
LOL! Let me add a bit: “Carbs r grate 4 bidness”
I had an aortic dissection. First, I woke up with chest pains, was taken to the hospital but had not had a heart attack. I went back home and a couple of nights later, I woke up with an odd lower pack pain. I was taken to the hospital again and that is when they found the aorta dissection. So, I had symptoms but not obviously connected to the aorta. I was flown to Oklahoma City for the operation. And, you’re right, the operation and recovery really takes it out of you. I’ve been told by several people that I’m fortunate to still be here.
It’s pretty amazing to me that all that could be done on short notice way out here in fly-over country.
“What’s important is the size of fat particles on the blood. Small particles are bad. But it’s hard or expensive or maybe impossible to measure that directly.”
Correct, but it’s regarding LDL, which are not fat particles in the sense of triglycerides, which are basically fat particles.
“The triglyceride to HDL ratio is a proxy for LDL particle size. A higher ratio suggests a greater proportion of smaller, denser LDL particles, which are more atherogenic (contribute to plaque buildup in arteries).””
Correct also, that the Triglyceride/HDL ratio is the key. Good to hear you’re back in the 1’s! I’ve actually gotten below 1.0, now about 0.7, but my servings of carbs* per week can be counted on 2 fingers (1 hand per week gets me to about 1.0). By the way, the ‘experts’ recommend around 10 servings PER DAY of carbs...no wonder they have so much business!
*carb servings as in rice, potatoes, corn, bread, noodles, sugar-drinks (like orange juice), and non-hard alcohol; I still eat vegetables and nuts, both of which have some carbs.
High cholesterol won’t kill you. High triglycerides will.
BS. Triglycerides are the natural results of fats in the presence of carbon and nitrogen. That’s all. Humans get high triglyceride levels when our livers get so damaged by alcohol and fructose ingestion that they become incompetent at converting ingested fats into healthy cholesterol. High triglyceride numbers are one of the best indicators of liver damage and future circulatory problems. They are a useful marker which can be improved by eliminating alcohol and fructose consumption.
You’ll be killed by something eventually... It’s just a matter of time, and time always runs out on all of us.
Bkkk
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.