Broccoli sprout compound shown to reduce prediabetes in study participants (Sulforaphane)

Medical Xpress / University of Gothenburg / Nature Microbiology ^ | Feb. 13, 2025 | Chinmay Dwibedi et al

[ConservativeMind]

Broccolli and a few other veggies have sulforaphane. This is also available in supplement form.

[ConservativeMind]

“Broccoli,” that is.

[ConservativeMind]

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[ProtectOurFreedom]

Broccoli sprouts are significantly richer in sulforaphane compared to mature broccoli. Studies have shown that broccoli sprouts can contain anywhere from 10 to 100 times more glucoraphanin, the precursor to sulforaphane, than mature broccoli heads. When these sprouts are chewed or chopped, the enzyme myrosinase converts glucoraphanin into sulforaphane.

While mature broccoli does contain sulforaphane, the levels are considerably lower than in sprouts. The exact amount can vary based on factors like the broccoli variety, how it's prepared, and even how long it's cooked, since heat can degrade the enzyme myrosinase needed to produce sulforaphane.

The concentration of sulforaphane in broccoli sprouts is much higher due to the young stage of growth where defense compounds like glucosinolates (which include glucoraphanin) are more concentrated.

To maximize sulforaphane content, both sprouts and broccoli should be eaten raw or lightly cooked. Cooking methods like boiling, steaming, or microwaving can reduce the amount of sulforaphane by inactivating myrosinase.

There's also variability in sulforaphane content due to different broccoli varieties, growing conditions, and the age of the plant at harvest. Broccoli sprouts are generally more consistent in their high glucoraphanin content.

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I'm not sure I've ever seen broccoli sprouts at the market. In any event, I doubt I'd ever eat enough sprouts of any kind to make a difference.

[peggybac]

Anyone know how to convert: “The participants were randomized to receive sulforaphane-containing BSE (150 μmol once daily) or placebo for 12 weeks.” to MG or MCG? Thanks!

[miniTAX]

There is a supposedly lowering of 0.2 mmol/l of fasting blood glucose for taking the chemical. Between different laboratories, methods and analytical reagents, deviations are bigger than 0.5.
So 0.2 is NOT ‘considerable’, it’s less than noise.
Yet another useless nutrition ‘research’, hyped up as ‘science’.

[DAC21]

Looks like I’m going to continue taking my Broccomax supplement. I read it may help with liver health and the reason I started on it a year or so back.

[steve86]

No, but as guidance for dosing:

Each capsule of Jarrow Formulas' BroccoMax contains 35 mg of sulforaphane glucosinolate (SGS), also known as glucoraphanin. In vitro studies have demonstrated that each delayed-release capsule yields approximately 8 mg of active sulforaphane. This formulation includes the myrosinase enzyme, which facilitates the conversion of SGS to sulforaphane in the small intestine. The suggested use is to take 1 to 3 capsules per day, 30 minutes before or after a meal

[steve86]

So up to 24 mg of active sulforaphane daily.

[steve86]

I used to take Broccomax but now a smaller amount of sulforaphane is included with one of my other supplements (I think berberine).

[zeestephen]

The old fashioned way to reduce pre-diabetes still works, too.

Reduce your consumption of sugar, all the way down to fasting, if necessary.

[ptsal]

The baby vegetable market may boom. It has always seemed like growing trays of veggies on the patio would be worthwhile. Then, I think about the summer in Texas. They would wilt.

[ptsal]

The baby vegetable market may boom. It has always seemed like growing trays of veggies on the patio would be worthwhile. Then, I think about the summer in Texas. They would wilt.

[Bobbyvotes]

I was diagnosed pre-diabetic 25 years ago. I have avoided diabetes with 25 minutes daily mild aerobic exercise. I am not a fan of broccoli sulphurous taste. My favorite veggies are spinach and sweet red peppers and Vidalia onions.

[takebackaustin]

By saying μmol I think they are saying microgram molecular weight, which requires you to know the molecular weight of sulfophorane.

A lot of times google search can do unit conversions So I tried:
sulforaphane-containing BSE 150 μmol to mg

And got back:

AI Overview
Learn more
150 micromoles (μmol) of sulforaphane is about 30 milligrams (mg).
Explanation
150 μmol of sulforaphane is about 30 mg.
Sulforaphane is a plant compound found in cruciferous vegetables, such as broccoli, kale, cauliflower, and kohlrabi.
Broccoli sprouts are a particularly potent source of sulforaphane, containing up to 1200 mg per 100 grams.

note: cheap AI tends to be innumerate. Fair warning.

[SisterK]

I grow my own sprouts. It is easy to do. But broccoli sprouts are too spicy or rank for me. Perhaps I should mix them with clover or alfalfa seed.

[mewzilla]

Bioavailability is likely much better if gotten in food, especially for older folks.

Mom was right.

Again.

Eat your veggies.

[mewzilla]

You might want to try this. FWIW, I like it...

Roasted Brussels Sprouts with Balsamic Vinegar and Honey

[SisterK]

I love roasted brussel sprouts.
But broccoli sprouts gag me.

[peggybac]

Thank you!