Benralizumab beneficial for eosinophilic exacerbations of asthma, chronic obstructive pulmonary disease

Medical Xpress / HealthDay / The Lancet Respiratory Medicine ^ | Dec. 10, 2024 | Elana Gotkine / Sanjay Ramakrishnan et al

[ConservativeMind]

Benralizumab can be used for the treatment of acute eosinophilic exacerbations of asthma and chronic obstructive pulmonary disease (COPD), according to a study.

Sanjay Ramakrishnan, M.B.B.S. and colleagues enrolled patients with blood eosinophil counts of ≥300 cells/µL at the time of an exacerbation of asthma or COPD and randomly assigned them to receive acute treatment with prednisolone 30 mg once daily for five days and 100 mg benralizumab subcutaneous injection once (BENRA plus PRED group; 52 patients); placebo tablets for five days plus 100 mg benralizumab subcutaneous injection once (BENRA group; 53 patients); or prednisolone 30 mg once daily for five days plus placebo subcutaneous injection once (PRED group; 53 patients).

The proportion of treatment failures over 90 days and total visual analog scale (VAS) symptoms at day 28 were compared in the pooled BENRA groups and the PRED group.

The researchers found that treatment failures occurred in 74 and 45% of patients in the PRED and pooled BENRA groups, respectively, at 90 days (odds ratio, 0.26). The total VAS mean difference was 49 mm at day 28, favoring the pooled BENRA groups. No fatal adverse events occurred, and benralizumab was well tolerated.

"The ABRA [Acute exacerbations treated with BenRAlizumab] study is the first trial to target the eosinophilic treatable trait, during exacerbations," the authors write. "This study shows that benralizumab is effective as an acute treatment of eosinophilic exacerbation."

[ConservativeMind]

Benralizumab (Fasenra) is available today.

This appears rather successful at helping those with acute eosinophilic exacerbations of asthma and chronic obstructive pulmonary disease (COPD).

[ConservativeMind]

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[Mr. K]

Are those all actual words?

[dp0622]

That wild!

I was JUST thinking how Benralizumab might be beneficial for my eosinophilic exacerbations.

I’ll be right back while I look up those words :)

Whatever it is, hope it helps folks.

[KarlInOhio]

Are those all actual words?

I think they're from Pokemon. Your Benralizumab beat my Eosinophilic.

[Berosus]

Most of the words in this article are not in my vocabulary.

[Ezekiel]

Are those all actual words?

🧐

I got sucked in for the same question.

If nothing else, it's a treasure trove of linguistic anomalies.

[MS.BEHAVIN]

Thanks for posting this!
PING to a couple of FRiends!

Norsky, can you help put this in laymen s terms?
Thanks!

[jonatron]

Someone told me it is very expensive.

In case you're curious what it's made of:

"Benralizumab is produced in Chinese hamster ovary cells by recombinant DNA..."