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Newly discovered mechanism in mitochondria could lead to new treatment for muscle disorders (Exercise bypasses problem)
Medical Xpress / University of Copenhagen / Nature Communications ^ | Dec. 6, 2024 | Tang Cam Phung Pham et al

Posted on 12/10/2024 3:10:25 PM PST by ConservativeMind

Researchers have discovered a mechanism in our cells that is essential to energy production in the muscles.

"We have identified a new, important mechanism for energy production of the muscle cells and shown that it is activated by physical exercise—regardless of age, gender and state of health," says Associate Professor Lykke Sylow.

The researchers demonstrate that a specific protein plays a key role in the energy production taking place in the cells' energy factory, the mitochondria. And they were surprised to find that through fitness training (so-called aerobic exercise), it is in fact possible to circumvent the role of this protein in energy production.

Tang Cam Phung Pham, explains, "Our research shows that exercise can counteract genetic errors in muscular energy production. If this protein is missing, exercise can activate alternative processes which recreate the muscle's energy capacity and circumvent the genetic error. This is extremely interesting, because it shows just how useful exercise is in overcoming genetic errors."

Though loss of muscle mass is normal, it is potentially lethal in some patient groups, including cancer patients.

"If we could increase patients' muscle mass, even just a little, when they enter cancer treatment, it could make the difference between life and death for some people."

The protein that is vital to the newly discovered mitochondrial mechanism is known as SLIRP.

In the study, the researchers also demonstrate that SLIRP stabilizes genes found in the mitochondria. Among other things, SLIRP is responsible for translating so-called mRNA into proteins that are essential for healthy, energy-producing mitochondria. If SLIRP is missing, though, the mitochondria are damaged and will be unable to produce sufficient energy. This is the process that physical exercise can help circumvent.

"Physical exercise is magic to the muscles," Sylow concludes.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: exercize; mitochondria; muscle
SLIRP helps our cells’ energy producers, mitochondria. However, it may not stay available to help. Thankfully, exercise provides the same benefit, bypassing the missing SLIRP.

Go work out!

1 posted on 12/10/2024 3:10:25 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

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2 posted on 12/10/2024 3:10:54 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Exercise changes the mitochondria in another way...it increases the capacity of mitochondria to utilize oxygen.

Making the engine of your entire metabolism more efficient.


3 posted on 12/10/2024 3:43:41 PM PST by Mariner (War Criminal #18)
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To: ConservativeMind

Put it in a lipid nano particle and mandate to all cancer patients.


4 posted on 12/10/2024 3:49:10 PM PST by wgmalabama (For rent….)
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To: ConservativeMind

Wait!

Exercise helps muscles?

Who knew!


5 posted on 12/10/2024 4:10:10 PM PST by Uncle Miltie ("Israel will just have to ... kill more Christians” - FR's own "nitzy")
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To: ConservativeMind
My cancer journey this year saw my weight drop from 161 lbs on the day of the Whipple surgery to a low of 136 lbs. Lots of muscle mass lost tethered in bed with IV drips attached. I'm making some headway with my weight up to 149 now. Exercise and proper nutrition will be key to recovering the loss. For reference, I'm 5 ft 11 in. A bit skinny after the cancer battle.
6 posted on 12/10/2024 5:24:16 PM PST by Myrddin
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To: Myrddin

Praying for you!


7 posted on 12/10/2024 5:30:12 PM PST by freepertoo
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To: ConservativeMind

bump for later


8 posted on 12/10/2024 7:57:05 PM PST by GOPJ (Will Lara Trump become the first woman President of the United States? )
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