Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

Ketone esters help clear misfolded proteins in mouse model of aging and Alzheimer's disease
Medical Xpress / Buck Institute for Research on Aging / Cell Chemical Biology ^ | Dec. 2, 2024 | John Newman, MD, Ph.D. et al

Posted on 12/03/2024 2:59:08 PM PST by ConservativeMind

Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular processes and aging mechanisms beyond energy production. Research shows that ketone bodies can best be understood as powerful signaling metabolites affecting brain function in aging and Alzheimer's disease.

A new study demonstrates that ketone bodies and similar metabolites have profound effects on the proteome and protein quality control in the brain.

Scientists, working on mouse models of Alzheimer's disease and aging, and in the nematode C. elegans, reveal the ketone body β-hydroxybutyrate interacts directly with misfolded proteins, altering their solubility and structure so they can be cleared from the brain through the process of autophagy.

Previous studies have shown that boosting ketone bodies through diet, exercise and supplementation can be good for brain health and cognition, both in rodents and humans.

In addition to testing the changing solubility and structure of proteins in test tubes, the project also involved feeding a ketone ester to mice to confirm that the test tube results were reproduced in the brain. In mice, the ketone ester treatment resulted in clearance rather than pathological aggregation of insoluble proteins.

The lab generated detailed proteome-wide solubility maps from both the test tube and mouse experiments.

To test if the solubility changes caused by ketone bodies helped improve models of pathological aggregation, the Lithgow lab fed ketone bodies to tiny nematode worms that were genetically modified to express the human equivalent of amyloid beta, which causes amyloid plaques.

"The amyloid beta affects muscles and paralyzes the worms," says Sidharth Madhavan, a Ph.D. candidate and lead author on the study. "Once they were treated with ketone bodies, the animals recovered their ability to swim. It was really exciting to see such a dramatic impact in a whole animal."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: alzheimer; antiaging; bhb; healthstats; keto; ketone
Navigation: use the links below to view more comments.
first 1-2021-24 next last
Your body makes β-hydroxybutyrate (BHB) when in ketosis. You can also start to make it after 16 hours of fasting.

You also can supplement or kick start it with MCT oil

BHB appears to let our bodies remove Alzheimers plaques. Strangely, it might happen more quickly than we would have realized.

1 posted on 12/03/2024 2:59:08 PM PST by ConservativeMind
[ Post Reply | Private Reply | View Replies]

To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 12/03/2024 2:59:43 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

That’s where the sudden lucidity arises when people are on their death beds and suddenly are cogent a period of time before passing.


3 posted on 12/03/2024 3:01:57 PM PST by Axenolith (BAGSTER! Pretty sure you can do an End Zone dance up there now! 🤣)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

What? Mice models don’t know how to fold proteins?


4 posted on 12/03/2024 3:02:07 PM PST by Larry Lucido (Donate! Don't just post clickbait!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

Damn, I’m good at the 12 hour fasts but I did a 24 and even a 48 and I saw spotted elephants :)

THANKS for the MCT oil tip.


5 posted on 12/03/2024 3:02:20 PM PST by dp0622 (Tried a coup, a fake tax story, tramp slander, Russia nonsense, impeachment and a virus. They lost.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Larry Lucido

They’re models. All they have to do is look good and let someone else fold the proteins for them.

I’ve never folded a protein myself, but I’ll admit I don’t know how to fold a fitted sheet. Personally, I doubt that anyone can.


6 posted on 12/03/2024 3:13:13 PM PST by HartleyMBaldwin
[ Post Reply | Private Reply | To 4 | View Replies]

To: ConservativeMind

Does this have to do with the Folding@Home FR group that gave complete, remote access of their desk top computers to the web?


7 posted on 12/03/2024 3:15:34 PM PST by Deaf Smith (When a Texan takes his chances, chances will be taken that's for sure.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Axenolith

That would be quite interesting to know.

AD patients typically eat carb-heavy.


8 posted on 12/03/2024 3:16:19 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: HartleyMBaldwin

You are correct!


9 posted on 12/03/2024 3:17:58 PM PST by Larry Lucido (Donate! Don't just post clickbait!)
[ Post Reply | Private Reply | To 6 | View Replies]

To: ConservativeMind

I wonder if coconut oil would have the same effect.


10 posted on 12/03/2024 3:29:16 PM PST by ChessExpert (The Democratic party must be destroyed.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: HartleyMBaldwin

You probably can only fold them 7 or8 times then you have to start over.


11 posted on 12/03/2024 3:42:17 PM PST by Liaison (TANSTAAFL)
[ Post Reply | Private Reply | To 6 | View Replies]

To: Liaison

Doesn’t matter how you try it, you’ll always end up with a sort-of-rectangular wad.


12 posted on 12/03/2024 3:47:00 PM PST by HartleyMBaldwin
[ Post Reply | Private Reply | To 11 | View Replies]

To: HartleyMBaldwin

Best results are obtained by rolling the fitted sheets around a 4” diameter section of drain pipe. It presses the sheets while rolling them up and if you tape the end or put rubber bands around it, it stays fairly flattened.

Does anyone know if Methyl Ethyl Ketone works the same as Ketone ? I have a can of it and I can just rub it on. That should work instead of swallowing it, right ?

Will the MEK be ok if I mix it with the MCT ?

And Who is Ester?


13 posted on 12/03/2024 4:57:37 PM PST by UCANSEE2 (The loudest person in the room is also the dumbest )
[ Post Reply | Private Reply | To 12 | View Replies]

To: HartleyMBaldwin

P.S. I heard that if you lick the back of the nematodes, it will get you high.


14 posted on 12/03/2024 4:59:25 PM PST by UCANSEE2 (The loudest person in the room is also the dumbest )
[ Post Reply | Private Reply | To 12 | View Replies]

To: UCANSEE2
And Who is Ester?

Wasn't she one of the actrresses on the Sanford and Son TV show way back when?

15 posted on 12/03/2024 5:08:28 PM PST by plsvn
[ Post Reply | Private Reply | To 13 | View Replies]

To: ConservativeMind

Yes, but can they fold a fitted sheet??


16 posted on 12/03/2024 5:33:00 PM PST by aMorePerfectUnion (🦅 MAGADONIAN ⚔️ LIFE )
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

Ping


17 posted on 12/03/2024 5:42:28 PM PST by AnglePark (My opinion is the most worthless thing I own.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ChessExpert

“Ordinary coconut oil can raise ketone levels but not as quickly or significantly as MCT oil. Its higher lauric acid content means ketone production is slower and more gradual, making it a supplementary fat source for ketosis rather than a primary tool for boosting ketone levels.”

—chatGPT


18 posted on 12/03/2024 5:50:38 PM PST by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
[ Post Reply | Private Reply | To 10 | View Replies]

To: ConservativeMind

I believe my CBD drops are made with MCT oil but not a cook or nutritionist and don’t know much about it.


19 posted on 12/03/2024 5:56:27 PM PST by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

I am of the opinion also that there is a synergistic process involved, probably with gut bacteria. If your gut flora is simple carb/sugar focused, they will emit chemicals that enhance your crave. My paternal grandmother suffered a head injury once, mild appearing in symptom, but involving a cranial hematoma. She went all-in on sugar, from bear claws to table spoons of it. Everybody (family) was all bummed. She was on a different world mentally and my parents were resigned to assisted living facility for her. I said she’d be fine after a few weeks in there with a guided diet, and sure enough she was out after a month. Back to normal for close to another decade before she passed.

Pop’s having issues with this (Alzheimer’s type stuff) now, but no one wants to put the hammer down on eating sweet/snacky things. And he’s not physically impaired by it, just neural (he’s a war machine still physically)


20 posted on 12/03/2024 7:59:51 PM PST by Axenolith (BAGSTER! Pretty sure you can do an End Zone dance up there now! 🤣)
[ Post Reply | Private Reply | To 8 | View Replies]


Navigation: use the links below to view more comments.
first 1-2021-24 next last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson