Posted on 10/15/2024 9:05:31 AM PDT by ConservativeMind
New research suggests intensive lifestyle interventions are an effective way of treating and improving liver disease.
In this study of 24 patients with metabolic dysfunction-associated steatohepatitis (MASH), a common liver disease caused by excessive fat buildup, one group followed a restricted diet and a high intensity interval training exercise program for 10 months. They dramatically improved their liver health over the control group of patients who received standard of care treatment.
Diet and exercise are the first lines of treatment for liver disease; however, this study is the first to examine the impact of diet and exercise on liver health and confirm the organ's recovery through imaging and diagnostic biopsies. These techniques allow for measurements of liver inflammation, fat buildup, fibrosis development and other indicators of liver health.
Nutritionists determined the best food intake for each participant and tracked their caloric and nutrient intake, and pathologists examined blood biochemistries with each blood sample taken.
The patients treated lost about 13–22 pounds and had increased muscle mass, while the control group lost 0-9 pounds. The peak oxygen uptake, considered an indicator of cardiovascular health and the ability to exercise, was much higher on average for the treatment group compared to the control. Insulin sensitivity, which measures how effectively cells convert glucose to energy, also increased for treated patients.
Obesity is one of the most prominent risk factors in developing MASH, and other conditions like high blood pressure and type 2 diabetes can contribute. Lifestyle interventions can be used to treat these conditions and reverse liver damage. It may even protect against future development of MASH.
Parks said, "We were able to show how diet and exercise should be the mainstay of treatment for the disease."
"Our findings suggest liver disease doesn't have to be a chronic, progressive condition," Parks said.
(Excerpt) Read more at medicalxpress.com ...
“Results”
“Treatment induced significant (p <0.05) reductions in body weight, fat mass, and liver injury, while VO2peak (p <0.05) and non-esterified fatty acid suppression (p = 0.06) were improved. Both groups exhibited reductions in total energy intake, hemoglobin A1c, hepatic insulin resistance, and liver fat (p <0.05). Compared to control, treatment induced a two-fold increase in peripheral insulin sensitivity which was significantly related to higher VO2peak and resolution of liver disease.”
“For the first time, these results show that an improvement in peripheral (but not hepatic) insulin sensitivity and systemic markers of muscle function (i.e. cardiorespiratory fitness) were strongly related to resolution of liver disease. Extrahepatic disposal of substrates and improved fitness levels supported histologic improvement, confirming the addition of exercise as crucial to lifestyle interventions in MASH.”
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The effects of pantethine on fatty liver and fat distribution (56% study participants eliminated fatty liver in six months)
My advice to older Freepers is to avoid loosing weight too fast. 7 years ago I lost 40 pounds in 6 months and that thickened up my bile, gave me gallstones, and ended up in the removal of my gallbladder a year later.
“...one group followed a restricted diet and a high intensity interval training exercise program for 10 months....
This is such a shock. A good diet and exercise can reduce fat and improve diebetes. Losing excess fat around organs is a good start to health. But you’ll notice they are not claiming over extended weight losses of over 10 pounds at a time. They are claiming of a consant weight loss of under 3 pounds monthly which is a safe weight loss for extended success of a person at 200 pounds. It’s relevent. But it is also the same thought process the American Diebetic Association, the AMA, and other medical associations and teaching institutes recommend. So, what’s the big deal? I’m missing their point.
wy69
From the writeup:
“Other studies investigated the impact of either diet or exercise on the liver, not both,” said study author Elizabeth Parks, Professor of Nutrition and Exercise Physiology. “In addition, similar studies were just observational, but at Mizzou, we have technology for metabolic imaging that can give in-depth data on liver disease.”
I had a liver test done earlier this year. During the preceeding 9 months, I had lost about 30 pounds and changed my exercise program to include HIIT.
I had the test because the outside of my liver was mottled, as one would expect from someone with liver issues cirhossis of the liver. I drank for 20 years and stopped when I was age 40. that was more than 30 years ago.
The testing guy said my liver was clear. He said it looked much better than most. I think that had to do with the weight loss and the HITT.
Nothing dangerous about losing 2 pounds a week. Heck, I did it a bunch of times over 45 years before going Keto and losing the weight for good. Long term success depends on finding a new way of eating - which is why the new diet needs to be one a person is willing to eat for the remainder of their life.
agree. I did the same thing with the same gall stone results. I almost lost my gall bladder
Wonderful news!
yeah. thanks
there was a second interesting thing the liver testing guy said.
He said that a clean liver generally means your cardiovascular health is going to be pretty good.
I did score a 300 for a calcium score in one part of my heart. the doctors were not concerned with the 300 but otherwise my numbers were all good.
“Long term success depends on finding a new way of eating...”
That’s half of it. If you look at every single weight loss recommendation you will always see that it is used with an exercise program addendum. I’m not a fan of keto as it restricts your carb content to below levels that forces the body into a metabolic state in its efforts to find fuel. In theory if you force the body to look for fuel and it isn’t there because you are running the body now on intake, there won’t be enough to keep the body running.
“In general, anyone who burns more calories than they take in will lose weight.”
https://my.clevelandclinic.org/health/body/21893-metabolism
Diet alone will not lose weight. If you are idle and use little calories, your body will adjust to a certain point. But in time you won’t have the energy to do more physically demanding things.
wy69
The term “technology for metabolic imaging” just means they can look at any particular area or organ and watch change. That can mean they can do it with any organ, MRI, Magnetic resonance imaging (MRI) is a non-invasive medical imaging technique that uses radio waves and strong magnetic fields to create detailed pictures of the inside of the body: Nothing new there.
wy69
“In theory if you force the body to look for fuel and it isn’t there...” Ummm...if you are trying to lose weight, then by definition, IT’S THERE! Hint: Fat people have fuel. The challenge is to access the fat as fuel without burning muscle. And WHY would you body burn muscle? Because insulin is telling your body to store fat even if it means burning muscle.
That is why I once dieted down to 120 pounds - a 5’8” male - and still had a layer of fat over my waist. And why Keto and IF solved the problem.
“Dr. Jason Fung - ‘Therapeutic Fasting - Solving the Two-Compartment Problem’”:
https://www.youtube.com/watch?v=tIuj-oMN-Fk
“Diet alone will not lose weight.”
Odd. I dieted successfully - lost weight - many times between 15 & 60. Using “eat less”. Fewer calories, period.
Bottom line for me? I spent 45 years doing yo-yo diets, successfully losing 30-50 pounds, then gaining it back, then losing, gaining, losing, gaining...
Starting at 60 (and now on Medicare for a while), I lost the fat. Pretty much ALL OF IT. Without going hungry. And kept it off. Off, off, off!
I’m glad you had success with keto. But thee are risks.
The keto diet could cause low blood pressure, kidney stones, constipation, nutrient deficiencies and an increased risk of heart disease. Strict diets like keto could also cause social isolation or disordered eating. Keto is not safe for those with any conditions involving their pancreas, liver, thyroid or gallbladder.
Some have had success but with the limitations of what can not be eaten. The diet restricts fresh fruits and vegetables, whole grains and low fat dairy that can help with long term weight loss and overall health. Hope you have continued success. I know a number of physicians that don’t recommend it and one in particular who was my PCM that tried it and found short term physical limitation. The main one being the loss of cardio needs like distance running as he reached failure in distance muscle needs rapidly.
wy69
Depends what you mean by “Keto”.
I eat Keto and I do eat plenty of fruits and vegetables. Berries are low-glycemic.
And distance running is one of the worst things you can do to your body. You are better off doing sprinting. Just compare the bodies of sprinters vs. distance runners.
“The keto diet could cause low blood pressure, kidney stones, constipation, nutrient deficiencies and an increased risk of heart disease.”
Seriously? That is simply nonsense! It has shown repeatedly it can lower HIGH blood pressure, and it tends to REDUCE kidney stones (fewer oxalates) and reduced fiber REDUCES constipation! Lower fiber plus more fat - it greases the skids, so to speak, and improves the flow.
Risk of heart disease? Something with a proven record of reducing fat, blood pressure, triglycerides while increasing HDL?
“Strict diets like keto could also cause social isolation or disordered eating.”
In what world? I’m serious because this is not something we need to guess about. Millions have tried it, benefited and stayed on it for years and decades. From your silly article, pushing the government approved view:
“More often than not, it’s not sustainable. Oftentimes weight gain may come back, and you’ll gain more than what you lost.”
Dude, I followed THEIR advice for 45 years. I know all about losing 30-45 pounds and then gaining it back! I know all about “unsustainable diets”! I did them - for 45 years!
“...they may consume excessive amounts of saturated fats that can increase your risk of heart disease.”
More hogwash. Saturated fat increases your HDL. That is about it. It doesn’t increase your total cholesterol, and total cholesterol isn’t actually meaningful anyways. The approved goal of getting everyone’s TC below 200 is DANGEROUS because the sweet spot for all cause mortality is 190-260, not “below 200”! And in women, TC doesn’t even correlated with ill health. Aside from young men, it is meaningless.
“my PCM that tried it and found short term physical limitation. The main one being the loss of cardio needs like distance running as he reached failure in distance muscle needs rapidly.”
Odd. After 7 years on the unsustainable diet, I ran 3.7 miles today. I’m in my upper 60s and average 18 miles/week. LOTS of people on permanent keto have no issues with building muscle or running. You might consider Shawn Baker:
https://www.youtube.com/@DrShawnBakerPodcast/videos
“Alex McDonald is an endurance athlete who defied conventional wisdom by running five consecutive marathons completely fasted. Despite facing skepticism and negative feedback from family and friends, Alex persisted with conviction and thorough preparation. Seeking advice and support from esteemed medical professionals like Dr. Paul Mason and Dr. Ian Lake, Alex meticulously documented his journey, combating injuries and enduring extreme heat, all while relying on fat reserves for energy.”
https://www.youtube.com/watch?v=vtT6VVdMidQ
“Executive summary
* An article has been published, which aimed to investigate the robustness of the claim that saturated fat clogs arteries and causes heart disease.
* I start this note with some basic facts about food, fat and saturated fat, which lead to the conclusion that it makes zero sense that saturated fat is harmful.
* The methodology of this study was a systematic review of other systematic reviews, from the past decade, to summarise the conclusions from all studies on saturated fat (SFA), cardiovascular disease (CVD) and deaths from cardiovascular disease.
* There were 32 studies found. Of the studies that reported on mortality, none found that saturated fat had a negative impact.
* For saturated fat and CVD (not deaths), the most common finding was evidence for SFA having no effect. The second most common finding was that SFA had a positive impact. Only 3 out of 32 studies found that SFA had a negative effect.
* The paper concluded that “this review provides strong evidence for absence of observed cardiovascular harm of SFA.”
* My PhD found the same. (My PhD papers were included in this review). My PhD has made no difference. The 32 studies in this review have made no difference. I expect that this latest paper will make no difference. The notion that saturated fat is harmful is absurd and has no evidence base. The dietary authorities don’t care.”
https://www.zoeharcombe.com/2022/11/saturated-fat-an-end-to-the-myth/
“Executive summary
* This week’s note examines the latest Cochrane report to be published on saturated fat and health outcomes (mortality and heart disease).
* The first Cochrane report on dietary fat was published in 2000 by Hooper et al. The same lead researcher, with varying colleagues, has produced the subsequent Cochrane dietary fat reports (2011, 2015 and 2020).
* The 2000 and 2011 reports were focused on dietary fat. The 2015 and 2020 reports were focused on saturated fat. This reflected changes in the 2015 US dietary guidelines, which became less concerned about total fat and more concerned about saturated fat.
* None of the four Cochrane reports has ever found anything for any dietary fat intervention (reduced or modified, total or saturated) for anything related to mortality. Not all-cause mortality, or cardiovascular disease (CVD) mortality, or coronary heart disease (CHD) mortality, or fatal heart attacks.
* None of the four Cochrane reports has ever found anything for any dietary fat intervention (reduced or modified, total or saturated) for anything related to CHD events, strokes or non-fatal heart attacks.
* The only claim that has ever been made by the Cochrane reports, in 20 years, is that long-term trials suggested that reducing dietary saturated fat reduced the risk of cardiovascular events. When this finding has been further examined – e.g. looking at trials that actually reduced saturated fat, rather than those that intended to, the findings have ceased to be significant.
* There have been no findings against total fat ever, and there have been no findings against saturated fat that have withstood scrutiny (as reported in the Cochrane publications themselves).
* There is nothing new in the 2020 report. This was admitted on P285 of 294. The other 293.75 pages were unnecessary.
* It is important to note that the two dietary fat guidelines (no more than 30% of calories in the form of total fat and no more than 10% of calories in the form of saturated fat), introduced in 1977/1983, are not evidence based and never can be evidence based. For something to be evidence based, the evidence must come first and there was no evidence for either guideline at the time they were introduced. That was the main finding from my PhD research and publications.
* Four other teams of researchers have examined fat and mortality and have also found nothing whatsoever against total fat, or saturated fat, for any combination of fat reduction or modification for any health outcome examined.
* The demonisation against saturated fat continues; the lack of evidence against saturated fat also continues. This is now a vendetta and it needs to stop.”
https://www.zoeharcombe.com/2020/06/cochrane-saturated-fat-reviews/
Mr Rogers,
After all this effort to show me how intelligent you are with all your utube sites and insults, it does come down to two interesting things:
I gave you a site at the University of Chicago medicine, and your bio indicates you are ex-military and I’ll guaranttee you didn’t train in the military using keto diet determinations to get you into the best shape you could be. So your argument is not with me, it’s with the opposing medical field people you disagree with. Send them an email.
wy69
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