Posted on 10/02/2024 8:57:28 PM PDT by ConservativeMind
Long-term treatment with finerenone is estimated to extend event-free survival among people with heart failure with mildly reduced or preserved ejection fraction, according to a brief report.
Muthiah Vaduganathan, M.D., M.P.H. and colleagues estimated the long-term treatment effects of finerenone if treated during a patient's lifetime in patients with heart failure with mildly reduced or preserved ejection fraction.
Analyses included data from the FINEARTS-HF trial, which was conducted in 37 countries across 653 sites. Participants, who were aged 40 years and older and had symptomatic heart failure and left ventricular ejection fraction of 40% or higher, were randomly assigned to finerenone (titrated to 20 or 40 mg) or placebo; 6,001 participants were included in the analysis.
The researchers found that for a 55-year-old participant, mean survival free from the primary composite outcome of time to cardiovascular death or worsening heart failure event was 13.6 and 10.5 years with finerenone and placebo, respectively, representing a gain of 3.1 years in event-free survival. For a 65-year-old participant, mean event-free survival was 11.0 and 8.9 years with finerenone and placebo, respectively, representing a gain of 2.0 years.
For every starting age between 50 and 80 years, the projected mean event-free survival was numerically greater with finerenone versus placebo. Even among individuals already treated with a sodium-glucose cotransporter 2 inhibitor, there were lifetime gains in event-free survival observed (3.1 years for a 65-year-old participant).
"The relative benefits reported during follow-up in the FINEARTS-HF trial can be interpreted together with these new projections of the expected absolute benefits with lifetime use of finerenone," the authors write.
(Excerpt) Read more at medicalxpress.com ...
is the mechanism for finerenone/kerendia sufficiently well understood such that it would be understood as to whether it would be good/not good for people who are do not show any symptoms of heart disease. would the drug be prophelactic in this case?
GoodRX prescriptions appear to be around $600 a month.
I would think there are known, healthy options to reduce cardio issues I would encourage, before something like this. There is no end to the items one would need to take to prevent various unknown maladies for the future, when we aren't showing symptoms.
Just eat, sleep, and exercise in healthier ways, supplementing what is practical and doesn't cause problems with other things you are also taking.
I joked with a relative who had a serious injury that we should have him constantly wrapped in bubble-wrap for the rest of his life. That would be helpful—but not practical, nor socially acceptable.
I was in the hospital for two days with heart failure a few years ago. I would not have been there if our $#%#$% governor had not closed the gyms because of covid. At the time I was doing a 14-minute mile on the treadmill five days a week. Exercise keeps your heart strong.
Take one prescription drug daily, lisinopril for heart failure, plus a dozen nutritional supplements. Saw my doctor last week and asked if I should have a cardiologist. He said I don’t need one. I’m trying to walk 30 minutes a day now, just building up to it. My vision Is so awful, I can’t drive anymore, so can’t get to the gym.
I joked with a relative who had a serious injury that we should have him constantly wrapped in bubble-wrap for the rest of his life.
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Someday if I ever get the extra cash, I’d like to buy a hyperbaric oxygen therapy tent. They’re too expensive for me right now. they usually cost from about 5k to 14k.
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