Posted on 09/25/2024 9:51:13 PM PDT by ConservativeMind
A research team led by Dr. Bin Li has highlighted the potential of malvidin-3-O-galactoside (M3G), a blueberry-derived anthocyanin, to improve colonic mucosal barrier function and alleviate colitis symptoms. They demonstrated that M3G enhances the integrity of the colonic barrier by regulating key proteins and Notch signaling pathways, suggesting its potential as a natural therapeutic agent for intestinal diseases.
The colonic mucosal barrier is essential for maintaining digestive health, protecting against pathogens, and preventing inflammation. M3G, a common anthocyanin in blueberries, has been studied for its health benefits, including its potential to regulate gut microbiota and protect against inflammation.
The study used a mouse model of colitis induced by dextran sulfate sodium (DSS) to mimic the inflammatory bowel conditions.
Mice were treated with M3G, and the outcomes were compared with untreated controls. Mice treated with DSS exhibited significant weight loss and increased DAI scores compared to the control group, indicating severe colitis. However, M3G supplementation significantly increased body weight, reduced DAI scores, and improved food intake, suggesting a protective effect against colitis symptoms.
Histological analysis of colon tissues revealed extensive epithelial damage in DSS-treated mice. M3G supplementation significantly reduced these pathological changes, lowering HE scores, and enhancing mucosal thickness and goblet cell numbers, indicating improved physical barrier function. Molecular assessments showed that M3G enhanced the expression of key barrier proteins. Additionally, M3G improved immune barrier function by increasing levels of secretory immunoglobulin A (SIgA) and reducing elevated CD4+T and CD8+T cell percentages.
Further analysis demonstrated that M3G inhibited the over-activation of the Notch signaling pathway. These results collectively indicate that M3G can effectively alleviate colonic barrier dysfunction in colitis, highlighting its potential therapeutic application.
"Our findings suggest that M3G has a significant therapeutic potential to enhance colonic barrier function," said Dr. Xinyao Jiao.
(Excerpt) Read more at medicalxpress.com ...
I am not aware of a supplement that assures this is caputured.
this is interesting in light of the thread recently about antibiotics adversely affecting the mucous lining of the digestive tract.
Maybe that’s why I’m craving blueberry muffins. Must be helping with the constipation over the last week.
Now tell me why I’m craving cherry and cheese danishes. What do they do?
I purchased blueberries bulk this year, freeze dried them, and vacuum packed them in quart jars with oxygen absorbers.
It’s the best snack I have found as the concentrated flavor explodes when the moisture in your mouth dissolves them.
They would keep forever in storage if they didn’t taste so good.
This article is very interesting for me as I lost 22 inches of my colon to cancer.
🙏
Great news, there! I’ll be getting me som blueberries, and passing on the tip to my daughter, who was recently diagnosed with Crohn’s disease. I don’t know how much it will help, but will it hurt? Crohn’s and UC do have their differences.
I take frozen blueberries and pour Kefir over them to make it a nice frozen treat.
That sounds great! I gotta try it! Thanks!
“Blueberry-derived compound shows promise in enhancing colonic mucosal barrier function”
Just what I always wanted! To enhance my colonic mucosal barrier function.
“A research team led by Dr. Bin Li has highlighted the potential of malvidin-3-O-galactoside (M3G), a blueberry-derived anthocyanin, to improve colonic mucosal barrier function and alleviate colitis symptoms. They demonstrated that M3G enhances the integrity of the colonic barrier by regulating key proteins and Notch signaling pathways, suggesting its potential as a natural therapeutic agent for intestinal diseases.”
NOW I get it!
ROTFLMAO!
Exactly what I was thinking!
May also help supress cancer too.
https://www.sciencedirect.com/science/article/pii/S2213453019302162
Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways
snip...."In conclusion, the results from this study demonstrated that Mv-3-gal suppressed hepatocellular carcinoma by inhibiting the proliferation, migration and invasion of Huh-7 cell, which was associated with its regulation on Akt/PTEN, MAPK and MMP pathways. These findings provide a theoretical basis for finding a potential auxiliary component or nutritional supplement for liver cancer prevention." see link for entire research and the article.
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