Posted on 09/14/2024 2:21:27 PM PDT by ConservativeMind
Researchers have delved deeper into the relationship between manganese deficiency and inflammatory bowel disease and found that low levels of the micronutrient can exacerbate intestinal injury and inflammation.
Their study centers around the genetic variant of the manganese transporter SLC39A8, which affects manganese levels in the body. People with a genetic variant in SLC39A8, or ZIP8, can have manganese deficiency, which this and prior studies have linked to inflammatory diseases of the intestines such as Crohn's and colitis.
"Our research reveals the crucial role of the manganese transporter SLC39A8 in maintaining healthy manganese levels and intestinal health. Our work also opens new therapeutic possibilities for IBD patients linked to manganese imbalance," said Young-Ah Seo.
Manganese is essential for many physiological functions of the body, including immune responses, bone formation and carbohydrate metabolism. The mineral, which occurs in the body and in foods and other minerals, is plentiful in plant-based foods such as whole grains, legumes, rice, nuts and vegetables. However, today's animal-based diets—meat, fish, poultry, eggs, dairy products—lack sufficient amounts of manganese.
The study cites evidence that dietary consumption of manganese has decreased by more than 40% in the past 15 years in developed countries, including the United States.
That decrease and deficiency are likely linked to a rise in diseases of the bowels, say the researchers, and that manganese deficiency may be responsible for weakening the epithelial barrier of the intestines, leading to disease.
SLC39A8 is essential to regulating manganese levels, acting as the trigger for cells to take in zinc, iron, manganese, and cadmium. SLC39A8-related diseases have only recently been discovered, and the impact of the disease-associated SLC39A8 A391T variant on human health and disease is just beginning to be appreciated.
(Excerpt) Read more at medicalxpress.com ...
Apparently, these were changes that helped get rid of my remaining large intestine pains.
I now get in 5-10 mg of manganese a day. The Upper Tolerable Limit is 11 mg, I believe.
Bkmk
No me bookmark
Which one?
magnesium glycinate
magnesium citrate
magnesium oxide
Manganese
Ng. Not. Gn
I never even heard of this. I kept thinking they’re spelling magnesium wrong.
OOPS!
I see the Manganese in my Glucosamoine/Chon — with MSM 87%
and its in my Calcium Citrate 50%
so it appears to be in my diet if I take those each day
Special note:
This is by far the most reckless article/study summary by med xpress I’ve read to date.
The takeaway is that supplementation may afford protection (I.e., “deficiency”), while the study itself cites a different solution altogether, without clarifying that abandoning the “western diet” may also be an effective solution (despite side mention thereof).
In fact, the upper limit of recommended manganese supplementation is 9-11mg, and OTC supplements deliver nearly 80% alone, thereby approaching toxic levels.
As well, the study authors cite the rarity of manganese deficiency prior to 40 years ago, but fail to cite how rare the genetic deficiency is among the populace.
The ONLY segment of the population this study serves are those who have been ill-served by their gastro mds and continue to suffer needlessly….unless you need yet another reason to rebel against the “western diet.”
Warning: Do NOT add standalone manganese supplements solely due to this post.
Ironically, this post also highlights one of the dangers of the keto fad.
(fire away)
The genetic variant allowed the study authors to realize the channel everyone must use. In other words, the exception proved the point.
My wife and I take 2.5 mg of manganese twice a day, by itself, with 50 mg of taurine, each time.
I had already reviewed all of our supplements and foods and determined we could easily, and safely, augment by 5+ mg a day.
That is, with “500 mg of taurine,” each time.
My second “0” didn’t get registered.
Women need 1.8 mg a day and men need 2.3 mg a day of manganese.
Top natural sources of manganese:
1. Blue Mussels: 5.8 mg, 251% Daily Value (DV)
2. Hazelnuts: 1.8 mg, 76% DV
3. Pecans: 1.3 mg, 56% DV
4. Brown Rice: 1.1 mg, 47% DV
5. Pacific Oysters: 1 mg, 45% DV
6. Clams: 0.9 mg, 37% DV
7. Chickpeas: 0.8 mg, 37% DV
8. Spinach: 0.8 mg, 37% DV
9. Pineapple: 0.8 mg, 33% DV
10. Soybeans: 0.7 mg, 31% DV
11. Oatmeal: 0.7 mg, 30% DV
12. Whole-Wheat Bread: 0.7 mg, 30% DV
13. Black Tea: 0.5 mg 23% DV
14. Lentils: 0.5 mg, 21%
15. Banana: 0.4 mg, 16% DV
16. Baked Potato: 0.3 mg, 14% DV
https://www.livestrong.com/article/13769669-foods-high-in-manganese/
There was no way our diet was supplying this every day, and my multivitamins and multiminerals did not have it.
Can you list the brand and supplement name for each?
google Periodic Table and you can see how manganese and magnesium are different, plus a lot of other stuff you might find interesting.
Obviously there are exceptions. My supplements have always included manganese.
The dangerous takeaway is “just go buy manganese tablets” but at the levels in some tablets inadvertent toxicity may occur.
I don’t subscribe to individual supplementation of nutrients unless a deficiency has been identified.
I just checked my “50+” multivitamin, and it has 2.3mg of manganese- according to the chart on the bottle that’s 100% of what I need. Thanks for the info, I haven’t had a colitis flair in a long time. BUT, I’m getting an Entyvio infusion every 8weeks, too. I guess I’m covered. For now, anyway…🙂
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